cytoplasmic membrane
07.01.1999;Kolpakov F.A.;created
08.01.2004;Nedosekina E.A.;edited
08.12.2002;Podkolodnaya O.A.;updated
18.10.2005;Kouznetsova T.N.;edited
22.01.2006;Podkolodnaya O.A.;edited
 3059.825303 2356.322144 31.982558 23.800416 cytoplasm
26.07.2001;Turn;updated
26.01.2002;Alex;updated
08.12.2002;Podkolodnaya O.A.;updated
07.01.1999;Kolpakov F.A.;created
08.01.2004;Nedosekina E.A.;edited
22.03.2004;Omelianchuk Nadya;edited
15.04.2005;Posukh O.L.;edited
15.08.2005;Kouznetsova T.N.;edited
22.01.2006;Podkolodnaya O.A.;edited
 2536.175232 2169.326537 234.608202 125.576891 nucleus
07.01.1999;Kolpakov F.A.;created
17.01.2002;Smirnova O.G.;updated
26.01.2002;Alex;updated
25.02.2004;Dubovenko E.A.;edited
03.03.2004;Gunbin K.V.;edited
 672.978516 510.556641 451.089599 634.550233 black white oval OAS12'-5' oligoadenylate synthetaseOIAS2'-5' OASHomo sapienshuman12TRRDA00269Hs:OASSWISS-PROTP00973OAS1_HUMANEMBLX06560OAS2'-5' oligoadenylate synthetase2'-5' A synthetaseHomo sapienshumanIFN-alphaHeLahuman tumor cell line, epithelial fibroblasts, cervical carcinoma cell lineHomo sapienshumanGuille M.J., Laxton C.D., Rutherford M.N., Williams B.R., Kerr I.M.Eur.J.Biochem.Functional differences in the promoters of the interferon-inducible (2'-5')A oligoadenylate synthetase and 6-16 genes in interferon-resistant Daudi cells.1994547553Wathelet M., Moutschen S., Cravador A., DeWit L., Defilippi P., Huez G., Content J.FEBS Lett.Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon.1986113120Wathelet M.G., Clauss I.M., Nols C.B., Content J., Huez G.A.Eur.J.Biochem.New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.1987313321Yamagata T., Nishida J., Tanaka T., Sakai R., Mitani K., Yoshida M., Taniguchi T., Yazaki Y., Hirai H.Mol.Cell.Biol.A novel Interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes199612831294Cohen B., Peretz D., Vaiman D., Benech P., Chebath J.EMBO J.Enhancer-like interferon responsive sequences of the human and murine (2'-5') oligoadenylate synthetase gene promoters.198814111419
08.12.2004;Ananko E.A.;edited
09.10.97;Ananko E.;created
 876.924561 667.467225 reactionindirectexperimental2'-5' oligoadenylate synthetaseHomo sapienshumanHomo sapienshumanNaganuma A., Nozaki A., Tanaka T., Sugiyama K., Takagi H., Mori M., Shimotohno K., Kato N.J.VirologyActivation of the interferon-inducible 2'-5'-oligoadenylate synthetase gene by hepatitis C virus core protein.200087448750
19.10.2004;Khlebodarova T.M.;edited
04.10.2004;Khlebodarova T.M.;edited
25.10.2004;Khlebodarova T.M.;edited
 887.487061 752.014100 CDKN1Ap21 Waf1 kinase inhibitorCip1SDI1WAF1CAP20CDKN1p21 Waf1Homo sapienshuman6p21.2EMBLU24170HS241701TRRDA00359Hs:WAF1cell cyclep53U937myelomonocytic cellsHomo sapienshumanHaCaTHaCaT keratinocytesHomo sapienshumanDatto M.B., Li Y., Panus J.F., Howe D.J., Xiong Y., Wang X.-F.Proc.Natl.Acad.Sci.USATransforming growth factor beta induces the cyclin-dependent TI kinase inhibitor p21 through a p53-independent mechanism.199555455549Halevy O., Novitch B.G., Spicer D.B., Skapek S.X., Rhee J., Hannon G.J., Beach D., Lassar A.B.ScienceCorrelation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.199510181021Liu M., Iavarone A., Freedman L.P.J.Biol.Chem.Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation.19963172331728 Expression of both p21 RNA and protein was indused during differentiation of C2 Muscle cells [Halevy O. et al., 1995]
25.05.2001;Grigoriev S.A.;updated
08.01.2002;Turn;updated
18.4.2000.;Stepanenko I.L.;created
16.05.2005;Ananko E.A.;edited
 533.979345 939.344851 reactionindirectexperimentalDouble-stranded RNA-specific adenosine deaminase Homo sapienshumanHomo sapienshumanDansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730
06.10.2004;Khlebodarova T.M.;created
06.10.2004;Khlebodarova T.M.;edited
 1019.819191 756.512819 PRKRinterferon-inducible dsRNA dependent protein kinaseprotein kinase, interferon-inducible double stranded RNA dependentinterferon-inducible elF2alpha kinasePKREIF2AK1Homo sapienshuman2GenBankNT_022184NT_022184GenBankNT_086610NT_086610PKRdsRNA-dependent cAMP-independent protein serine/threonine kinaseInterferon-induced, double-stranded RNA-activated protein kinasedsRNA-dependent eIF-2alpha protein kinasep68 kinaseInterferon-inducible RNA-dependent protein kinaseP1/eIF-2A protein kinaseTIK proteinHomo sapienshumanWard S.V., Samuel C.E.VirologyRegulation of the interferon-inducible PKR kinase gene: the KCS element is a constitutive promoter element that functions in concert with the interferon-stimulated response element.2002136146Kuhen K.L., Samuel C.E.VirologyMechanism of interferon action: functional characterization of positive and negative regulatory domains that modulate transcriptional activation of the human RNA-dependent protein kinase Pkr promoter.1999182195Xu Z., Williams B.R.J.Interferon Cytokine Res.Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5'-untranslated region.1998609616 698.028076 671.537722 reactionindirectexperimentalinterferon-inducible dsRNA dependent protein kinaseHomo sapienshumanHomo sapienshumanDansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730
07.10.2004;Khlebodarova T.M.;created
07.10.2004;Khlebodarova T.M.;edited
 747.574951 755.147097 GBP1guanylate-binding protein 167 kDa guanylate-binding protein 1Interferon-induced guanylate-binding protein 1Guanine nucleotide-binding protein 1Homo sapienshuman1SWISS-PROTP32455GBP1_HUMANTRRDA00200Hs:GBPGenBankBC002666BC002666GDBGDB:378351GBP1GBPguanylate-binding proteinHomo sapienshumanIFN-gammaIFN-alphaFibroblastFibroblastsHomo sapienshumanDecker T., Lew D.J., Cheng Y.S., Levy D.E., Darnell J.E. Jr.EMBO J.Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.198920092014Decker T., Lew D. J., Darnell J. E.Mol.Cell.Biol.Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene199151475153Decker T., Lew D.J., Mirkovitch J., Darnell J.E. Jr.EMBO J.Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.1991927932Eilers A., Baccarini M., Horn F., Hipskind R.A., Schindler C. and Decker T.Mol.Cell.Biol.A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site.199413641373Lew D.J., Decker T., Strehlow I., Darnell J.E.Mol.Cell.Biol.Overlapping elements in the guanilate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.1991182191Lew D.J., Decker T., Darnell J.E. Jr.Mol.Cell.Biol.Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.198954045411Mirkovitch J., Decker T., Darnell J.E. Jr.Mol.Cell.Biol.Interferon induction of gene transcription analyzed by in vivo footprinting.199219Nees M., Geoghegan J.M., Hyman T., Frank S., Miller L., Woodworth C.D.J.VirologyPapillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes.200142834296Seegert D., Strehlow I., Klose B., Levy D.E., Schindler C., Decker T.J.Biol.Chem.A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene.199485908595Yamagata T., Nishida J., Tanaka T., Sakai R., Mitani K., Yoshida M., Taniguchi T., Yazaki Y., Hirai H.Mol.Cell.Biol.A novel Interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes199612831294
15.12.2002;Ananko E.;created
08.10.2004;Ananko E.A.;edited
 798.418703 665.209597 reactionindirectexperimentalguanylate-binding protein 1Homo sapienshumanHomo sapienshumanDansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730
07.10.2004;Khlebodarova T.M.;created
07.10.2004;Khlebodarova T.M.;edited
 810.606203 749.240847 p53p53 tumor suppressorHomo sapienshumanTRRDA00307Hs:P53p53FibroblastFibroblastsHomo sapienshumanDi Leonardo A., Linke S.P., Clarkin K., and Wahl G.M.Genes Dev.DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.199425402551
18.4.2000.;Stepanenko I.L.;created
15.11.2000;Grigoriev S.A.;updated
 590.499954 999.977565 PCNAproliferating cell nucleolar antigen p120Homo sapienshumanTRRDA00368Hs:PCNAEMBLJ05614HSPCNAPREMBLJ04718HSPCNASWISS-PROTP12004PCNA_HUMANSaos-2Saos-2 osteosarcoma cell lineHomo sapienshuman
27.01.2002;Turn;created
 651.917007 1023.825044 c-fosc-fos protooncogeneHomo sapienshumanTRRDA00110Hs:CFOSheat shocktBHQt-BHQFisch T.M., Prywes R., Roeder R.G.Mol.Cell.Biol.c-fos sequences necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate,and the calcium ionophore198734903502
19.4.2000.;Stepanenko I.L.;created
19.10.2000;Stepanenko I.L.;updated
11.12.2001;Turn;updated
08-Apr-02.;Alena N.;updated
 714.182632 1016.246919 ADARDouble-stranded RNA-specific adenosine deaminase DRADAADAR1DSRADIFI4Homo sapienshumanSWISS-PROTP55265DSRA_HUMANTRRDA02446Hs:ADAR1EMBLU32571HS325711ADAR1Double-stranded RNA-specific adenosine deaminase 136 kDa double-stranded RNA binding proteinInterferon-inducible protein 4Homo sapienshumanGeorge C.X., Samuel C.E.GeneCharacterization of the 5'-flanking region of the human RNA-specific adenosine deaminase ADAR1 gene and identification of an interferon-inducible ADAR1 promoter.1999203213Dansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730
07.10.2004;Khlebodarova T.M.;edited
 952.866060 705.653444 TNF-alphatumor necrosis factor alphaHomo sapienshumanTRRDA00266Hs:TNFATNF-alphaB-cellB-lymphocytesHomo sapienshumanJurkatCD4+ T lymphoblastoid cell lineHomo sapienshumanT-cellT-lymphocytesHomo sapienshumanU937myelomonocytic cellsHomo sapienshumanKamijo R., Harada H., Matsuyama T., Bosland M., Gerecitano J., Shapiro D., Le J., Koh S.I., Kimura T., Green S.J., Mak T.W., Taniguchi T., Vilcek J.ScienceRequirement for transcription factor IRF-1 in NO synthase induction in macrophages.199416121615Preischl E.E., Pendl G.G., Elbe A., Serfling E., Harrer N.E., AU Stingl G., and Baumruker T.J.Immunol.Induction of the TNF-alpha promoter in the murine dendritic cell line 18 and the murine mast cell line CPII is differently regulated.199626452653Tsai E.Y., Jain J., Pesavento P.A., Rao A., and Goldfeld A.E.Mol.Cell.Biol.Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp.1996459467Tsai E.Y., Yie J., Thanos D., and Goldfeld A.E.Mol.Cell.Biol.Cell-type-specific regulation of the human Tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/JUN.199652325244Zagariya A., Mungre S., Lovis R., Birrer M., Ness S., Thimmapaya B., and Pope R.Mol.Cell.Biol.Tumor Necrosis Factor alpha gene regulation: enhancement of C/EBPbeta-induced activation by c-Jun.199828152824
19.4.2000.;Stepanenko I.L.;created
09.10.2000;Nedosekina E.A.;updated
15.11.2000;Grigoriev S.A.;updated
24-Oct-02.;Stepanenko I.L.;updated
 783.310549 1031.000305 FCHferrochelataseHomo sapienshuman18q21.3all cell typesall cell typesHomo sapienshumanbone marrow derived CFUbone marrow derived CFUHomo sapienshumanbrainbrainHomo sapienshumanerythroblasterythroblastHomo sapienshumanheartheartHomo sapienshumankidneykidneyHomo sapienshumanliverliverHomo sapienshumanspleenspleenHomo sapienshumanPonka P.BloodTissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.1997125Tugores A., Magness S.T., Brenner D.A.J.Biol.Chem.A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene.19943078997
23.6.1999.;Podkolodnaya O.A.;created
23.6.2000.;Podkolodnaya O.A.;updated
 843.310549 1023.006409 NS3Protease/helicase NS3 HepacivirinP70Hepatitis C virushuman hepatitis C virusSWISS-PROTP26660POLG_HCVJ6activemonomerLove R.A., Parge H.E., Wickersham J.A., Hostomsky Z., Habuka N., Moomaw E.W., Adachi T., Hostomska Z.CellThe crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.1996331342Yao N., Hesson T., Cable M., Hong Z., Kwong A.D., Le H.V., Weber P.C.Nat.Struct.Biol.Structure of the hepatitis C virus RNA helicase domain.1997463467Wang W., Lahser F.C., Yi .M., Wright-Minogue J., Xia E., Weber P.C., Lemon S.M., Malcolm B.A.J.VirologyConserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition.2004700709Shoji I., Suzuki T., Sato M., Aizaki H., Chiba T., Matsuura Y., Miyamura T.VirologyInternal processing of hepatitis C virus NS3 protein.1999315323Yao N., Hesson T., Cable M., Hong Z., Kwong A.D., Le H.V., Weber P.C.Nat.Struct.Biol.Structure of the hepatitis C virus RNA helicase domain.1997463467Locatelli G.A., Gosselin G., Spadari S., Maga G.J.Molec.Biol.Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.2001683694Muramatsu S., Ishido S., Fujita T., Itoh M., Hotta H.J.VirologyNuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.199749544961Kim J.L., Morgenstern K.A., Griffith J.P., Dwyer M.D., Thomson J.A., Murcko M.A., Lin C., Caron P.R.StructureHepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.199889100
05.10.2004;Khlebodarova T.M.;edited
11.10.2004;Khlebodarova T.M.;edited
15.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
06.10.2004;Khlebodarova T.M.;edited
25.11.2004;Khlebodarova T.M.;edited
 1052.404299 869.398621 IRF-1interferon regulatory factor -1ISGF2Homo sapienshumanSWISS-PROTP10914IRF1_HUMANTRRDA00276Hs:IRF1IRF-1ISGF2MARinterferon regulatory factor 1Homo sapienshumanactiveno datamonomerleukemia inhibitory factorLIFprolactinIFN-alphaIFN-gammadsRNAIL-6IFN-betaTNF-alphaIL-1IL-1 alphaIL-1alphavirus infection (NDV)NDVMacrophageMacrophagesHomo sapienshumanHeLahuman tumor cell line, epithelial fibroblasts, cervical carcinoma cell lineHomo sapienshumanHuh-7human hepatoma cell lineHomo sapienshumanKanazawa N., Kurosaki M., Sakamoto N., Enomoto N., Itsui Y., Yamashiro T., Tanabe Y., Maekawa S., Nakagawa M., Chen C.H., Kakinuma S., Oshima S., Nakamura T., Kato T., Wakita T., Watanabe M.J.VirologyRegulation of hepatitis C virus replication by interferon regulatory factor 1.200497139720Nakagawa K., Yokosawa H.Eur.J.Biochem.Degradation of transcription factor IRF-1 by the ubiquitin-proteasome pathway. The C-terminal region governs the protein stability.200016801686 Is a short-lived protein, degradated via ubiquitin-proteasome pathway [Nakagava K-2000]. Nakagawa K., Yokosawa H.Eur.J.Biochem.Degradation of transcription factor IRF-1 by the ubiquitin-proteasome pathway. The C-terminal region governs the protein stability.200016801686
09.10.97;Ananko E.;created
09.10.2001;Nedosekina E.A.;updated
07.10.2004;Ananko E.A.;edited
04.12.2004;Ananko E.A.;edited
 688.080079 875.157532 LMP2Proteasome subunit beta type 9 Proteasome chain 7Macropain chain 7Multicatalytic endopeptidase complex chain 7RING12 proteinLow molecular mass protein 2 PSMB9RING12Homo sapienshumanGenBank X66401 HSMHCAPGKhu Y.L., Tan Y.J., Lim S.G., Hong W., Goh P.Y.Biochem.J.Hepatitis C Virus nonstructural protein NS3 interacts with LMP7, a component of immunoproteasome, and affects its proteasome activity.2004133
11.10.2004;Khlebodarova T.M.;edited
 547.720703 738.423157 GBP2GTP-binding protein 2Interferon-induced guanylate-binding protein 2 Guanine nucleotide-binding protein 2 HuGBP-2Homo sapienshumanHuh-7human hepatoma cell lineHomo sapienshumanPflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655 619.283204 698.688782 irreversible reactionindirectexperimentalGTP-binding protein 2Homo sapienshumanHomo sapienshumanPflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655
18.10.2004;Khlebodarova T.M.;created
18.10.2004;Khlebodarova T.M.;edited
 681.205079 764.673157 regulatory eventincreasedirectexperimentalinterferon regulatory factor -1Homo sapienshumanPflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655
18.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;created
 686.517579 819.282532 regulatory eventincreasedirectexperimentalinterferon regulatory factor -1Homo sapienshumanPflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655
18.10.2004;Khlebodarova T.M.;created
18.10.2004;Khlebodarova T.M.;edited
 632.330079 843.657532 regulatory eventincreaseindirectexperimentalHepatitis C virushuman hepatitis C virusPflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655dsRNA induced a > 14-fold increase in IRF-1 DNA-binding function.Pflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655
18.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;created
 1031.455079 776.720032 RNASEL2-5A-dependent ribonucleaseRNS4Homo sapienshumanEMBLL10381HS25RNASEFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131 472.574342 875.014343 regulatory eventincreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusDansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730
20.10.2004;Khlebodarova T.M.;created
20.10.2004;Khlebodarova T.M.;edited
 757.808350 863.663268 regulatory eventincreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusDansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730
20.10.2004;Khlebodarova T.M.;created
20.10.2004;Khlebodarova T.M.;edited
 780.433350 861.475768 regulatory eventincreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusNaganuma A., Nozaki A., Tanaka T., Sugiyama K., Takagi H., Mori M., Shimotohno K., Kato N.J.VirologyActivation of the interferon-inducible 2'-5'-oligoadenylate synthetase gene by hepatitis C virus core protein.200087448750Dansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730
20.10.2004;Khlebodarova T.M.;edited
25.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;created
 803.308350 857.725768 regulatory eventincreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusDansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730
20.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;created
 825.745850 856.100768 pRBretinoblastoma susceptibility gene 1Homo sapienshumanTRRDA00329Hs:RBGcell cycleMGH-U1bladder cancer MGH-U1 cellsHomo sapienshumanSaos-2Saos-2 osteosarcoma cell lineHomo sapienshumanShan B., Chang C.Y., Jones D., Lee W.H.Mol.Cell.Biol.The transcription factor E2F-1 mediates the autoregulation of RB gene expression.1994299309 The expression of RB gene is increased graduallly during the G1 transition and peaks at the G1/S boundary, reduce in S and low in G2.
05.12.2001;Turn;created
 900.527344 1029.567321 grp7878-kD glucose-regulated proteinHomo sapienshumanTRRDA00576Hs:GRP78heminprostaglandin A1PGA1Amici C., Sistonen L., Santoro M.G., Morimoto R.I.Proc.Natl.Acad.Sci.USAAntiproliferative prostaglandins activate heat shock transcription factor199262276231
27.7.2000.;Stepanenko I.L.;created
 895.609375 872.418884 grp9494 kDa glucose-regulated proteinTumor rejection antigen 1Endoplasmin TRA1Homo sapienshumanTRRDA02234 Hs:GRP94Liberman E., Fong Y.L., Selby M.J., Choo Q.L., Cousens L., Houghton M., Yen T.S.J.VirologyActivation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.199937183722 1010.862306 995.202574 p50ATF6Cyclic-AMP-dependent transcription factor ATF-6 betacAMP responsive element binding protein-like 1cAMP response element binding protein-related proteinG13 proteinCREBL1Activating transcription factor 6 betaHomo sapienshumanSWISS-PROTQ99941AT6B_HUMANactivehomodimerHaze K., Yoshida H., Yanagi H., Yura T., Mori K.Mol.Biol.CellMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.199937873799
25.10.2004;Khlebodarova T.M.;edited
 938.505859 946.196227 regulatory eventincreasedirectexperimentalCyclic-AMP-dependent transcription factor ATF-6 betaHomo sapienshumanHaze K., Yoshida H., Yanagi H., Yura T., Mori K.Mol.Biol.CellMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.199937873799Yoshida H., Haze K., Yanagi H., Yura T., Mori K.J.Biol.Chem.Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors.19983374133749
25.10.2004;Khlebodarova T.M.;edited
 1018.924805 945.454529 regulatory eventincreasedirectexperimentalCyclic-AMP-dependent transcription factor ATF-6 betaHomo sapienshumanYoshida H., Haze K., Yanagi H., Yura T., Mori K.J.Biol.Chem.Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors.19983374133749Haze K., Yoshida H., Yanagi H., Yura T., Mori K.Mol.Biol.CellMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.199937873799
25.10.2004;Khlebodarova T.M.;edited
 1025.174805 959.204529 irreversible reactionindirectexperimental78-kD glucose-regulated proteinHomo sapienshumanHomo sapienshumanLiberman E., Fong Y.L., Selby M.J., Choo Q.L., Cousens L., Houghton M., Yen T.S.J.VirologyActivation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.199937183722
21.10.2004;Khlebodarova T.M.;edited
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06.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
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17.11.2004;Khlebodarova T.M.;created
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18.01.2002;Turn;updated
11.10.2000;Grigoriev S.A.;created
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22.11.2004;Khlebodarova T.M.;created
22.11.2004;Khlebodarova T.M.;edited
 1006.800049 881.200012 irreversible reactionindirectexperimentalretinoblastoma susceptibility gene 1Homo sapienshumanHomo sapienshumanCho J., Baek W., Yang S., Chang J., Sung Y.C., Suh M.Biochim.Biophys.ActaHCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation.20015966
21.10.2004;Khlebodarova T.M.;edited
 952.281250 1079.497009 irreversible reactionindirectexperimentalferrochelataseHomo sapienshumanHomo sapienshumanDumoulin F.L., von dem Bussche A., Li J., Khamzina L., Wands J.R., Sauerbruch T., Spengler U.VirologyHepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines.2003260266
15.10.2004;Khlebodarova T.M.;edited
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15.10.2004;Khlebodarova T.M.;edited
 867.023928 1106.886475 reactionindirectexperimentalp53 tumor suppressorHomo sapienshumanHomo sapienshumanZakut-Houri R., Bienz-Tadmor B., Givol D., Oren M.EMBO J.Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.198512511255
07.10.2004;Khlebodarova T.M.;edited
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18.10.2004;Khlebodarova T.M.;edited
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06.10.2004;Khlebodarova T.M.;edited
 562.724359 1048.417995 - HCV_rhepatitis C virus repliconHepatitis C virushuman hepatitis C virusmRNAGenBankNC_004102NC_004102HCVHepatitis C virusHepatitis C virushuman hepatitis C virus
04.10.2004;Khlebodarova T.M.;created
13.10.2004;Ananko E.A.;edited
12.04.2006;Mishchenko E.L.;edited
 1305.342041 471.100526 EPR membrane
05.10.2004;Khlebodarova T.M.;created
 544.342774 690.514649 1326.946777 1554.257020 black lightgreen 40 rounded_rect NS5ANonstructural protein NS5Ap56Hepatitis C virushuman hepatitis C virusSWISS-PROTP26664POLG_HCV1activeno dataTellinghuisen T.L., Marcotrigiano J., Gorbalenya A.E., Rice C.M.J.Biol.Chem.The NS5A protein of hepatitis C virus is a zinc metalloprotein.2004143Shirota Y., Luo H., Qin W., Kaneko S., Yamashita T., Kobayashi K., Murakami S.J.Biol.Chem.Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity.20021114911155Elazar M., Cheong K.H., Liu P., Greenberg H.B., Rice C.M., Glenn J.S.J.VirologyAmphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication.200360556061Locarnini S.A., Bartholomeusz A.J.Gastroenterol.Hepatol.Advances in hepatitis C: what is coming in the next 5 years?2002442447Brass V., Bieck E., Montserret R., Wolk B., Hellings J.A., Blum H.E., Penin F., Moradpour D.J.Biol.Chem.An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A.200281308139Gale M. Jr., Blakely C.M., Kwieciszewski B., Tan S.L., Dossett M., Tang N.M., Korth M.J., Polyak S.J., Gretch D.R., Katze M.G.Mol.Cell.Biol.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.199852085218Geiss G.K., Carter V.S., He Y., Kwieciszewski B.K., Holzman T., Korth M.J., Lazaro C.A., Fausto N., Bumgarner R.E., Katze M.G.J.VirologyGene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.200363676375The PKR-binding domain of NS5A is localized to within the ISDR (IFN sensitivity-determining region, aa 2209 to 2248).Gale M. Jr., Blakely C.M., Kwieciszewski B., Tan S.L., Dossett M., Tang N.M., Korth M.J., Polyak S.J., Gretch D.R., Katze M.G.Mol.Cell.Biol.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.199852085218At least 200 genes were differentially regulated in response to NS5A expression.Geiss G.K., Carter V.S., He Y., Kwieciszewski B.K., Holzman T., Korth M.J., Lazaro C.A., Fausto N., Bumgarner R.E., Katze M.G.J.VirologyGene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.200363676375Several signaling pathways were affected by NS5A expression. NS5A appeared to have a significant effect on calcium signaling.Geiss G.K., Carter V.S., He Y., Kwieciszewski B.K., Holzman T., Korth M.J., Lazaro C.A., Fausto N., Bumgarner R.E., Katze M.G.J.VirologyGene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.200363676375
01.10.2004;Ananko E.A.;created
04.10.2004;Khlebodarova T.M.;edited
04.10.2004;Ananko E.A.;edited
12.10.2004;Ananko E.A.;edited
 1420.604004 1594.370301 EPRendoplasmic reticulum
30.09.2004;Stepanenko I.L.;edited
24.6.1999.;Busygina T.V.;created
05.10.2004;Khlebodarova T.M.;edited
19.04.2006;Agapova T.Yu.;edited
 229.483399 180.046875 1447.311034 1880.729677 lightyellow black rounded_rect endoplasmic reticulum stress ER stressER stressWaris G., Tardif K.D., Siddiqui A.Biochem.Pharmacol.Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3.200214251430
08.05.2002;Stepanenko I.L.;created
25.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
 1598.849122 1924.651733 40 + HCV_rHepatitis C virus repliconhuman hepatitis virus C HCV repliconhuman hepatitis C virus repliconHepatitis C virushuman hepatitis C virusmRNAGenBankNC_004102NC_004102EMBLAJ000009HCVPOLYPEMBLD89815D89815EMBLD28917HPCK3AEMBLD17763HPCEGSEMBLD30613HPCPPEMBLD10934HPCRNAEMBLM67463HPCRNAEMBLD13558HPCJ483HCVHepatitis C virusHepatitis C virushuman hepatitis C virusLyons A.J., Robertson H.D.J.Biol.Chem.Detection of tRNA-like structure through RNase P cleavage of viral internal ribosome entry site RNAs near the AUG start triplet.20032684426850Dumas E., Staedel C., Colombat M., Reigadas S., Chabas S., Astier-Gin T., Cahour A., Litvak S., Ventura M.Nucl.Acids Res.A promoter activity is present in the DNA sequence corresponding to the hepatitis C virus 5' UTR.200312751281Lohmann V., Korner F., Koch J., Herian U., Theilmann L., Bartenschlager R.ScienceReplication of subgenomic hepatitis C virus RNAs in a hepatoma cell line.1999110113single-stranded, positive-sense RNA
30.09.2004;Ananko E.A.;edited
30.09.2004;Ananko E.A.;created
04.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
05.12.2004;Ananko E.A.;edited
12.04.2006;Mishchenko E.L.;edited
11.11.2004;Khlebodarova T.M.;edited
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18.10.2004;Khlebodarova T.M.;created
 10.8 h NS4BNonstructural protein NS4B P27Hepatitis C virushuman hepatitis C virusSWISS-PROTP26660POLG_HCVJ6;activemonomerElazar M., Cheong K.H., Liu P., Greenberg H.B., Rice C.M., Glenn J.S.J.VirologyAmphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication.200360556061Hugle T., Fehrmann F., Bieck E., Kohara M., Krausslich H.G., Rice C.M., Blum H.E., Moradpour D.VirologyThe hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein.20017081 1554.209474 1686.391785 Characterization of cell lines carrying self-replicating hepatitis C virus RNAs. Pietschmann T., Lohmann V., Rutter G., Kurpanek K., Bartenschlager R. J.Virology 2001 1252 1264
18.10.2004;Khlebodarova T.M.;created
 12 h NS5BNonstructural protein NS5BRNA-directed RNA polymeraseP70P66Hepatitis C virushuman hepatitis C virusSWISS-PROTP26660POLG_HCVJ6activephosphorylatedmultimerWang Q.M., Hockman M.A., Staschke K., Johnson R.B., Case K.A., Lu J., Parsons S., Zhang F., Rathnachalam R., Kirkegaard K., Colacino J.M.J.VirologyOligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.200238653872Shirota Y., Luo H., Qin W., Kaneko S., Yamashita T., Kobayashi K., Murakami S.J.Biol.Chem.Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity.20021114911155Yamashita T., Kaneko S., Shirota Y., Qin W., Nomura T., Kobayashi K., Murakami S.J.Biol.Chem.RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region.19981547915486Bressanelli S., Tomei L., Roussel A., Incitti I., Vitale R.L., Mathieu M., De Francesco R., Rey F.A.Proc.Natl.Acad.Sci.USACrystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.19991303413039Leveque V.J., Johnson R.B., Parsons S., Ren J., Xie C., Zhang F., Wang Q.M.J.VirologyIdentification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: structural and biochemical analysis.200390209028Lohmann V., Korner F., Herian U., Bartenschlager R.J.VirologyBiochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity.199784168428Behrens S.E., Tomei L., De Francesco R.EMBO J.Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus.19961222Tanaka T., Sugiyama K., Ikeda M., Naganuma A., Nozaki A., Saito M., Shimotohno K., Kato N.Microbiol.Immunol. Hepatitis C virus NS5B RNA replicase specifically binds ribosomes.2000543550NSB5B acts as a functional oligomer with a dissociation constant Kd ~ 22nMWang Q.M., Hockman M.A., Staschke K., Johnson R.B., Case K.A., Lu J., Parsons S., Zhang F., Rathnachalam R., Kirkegaard K., Colacino J.M.J.VirologyOligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.200238653872NS5B binds ribosomes and the ribosome-bound form of NS5B is highly active for RNA replication.Tanaka T., Sugiyama K., Ikeda M., Naganuma A., Nozaki A., Saito M., Shimotohno K., Kato N.Microbiol.Immunol. Hepatitis C virus NS5B RNA replicase specifically binds ribosomes.2000543550
05.10.2004;Khlebodarova T.M.;edited
06.10.2004;Khlebodarova T.M.;edited
08.10.2004;Khlebodarova T.M.;edited
 1651.870607 1675.147309 Cpcore proteinHepatitis C virushuman hepatitis C virusSWISS-PROTQ01404POLG_HCVH4SWISS-PROTP27959POLG_HCVJ2TrEMBLP87760P87760TrEMBLQ8BER8Q8BER8TrEMBLQ8BES0Q8BES0activemultimerOkamoto H., Kurai K., Okada S., Yamamoto K., Lizuka H., Tanaka T., Fukuda S., Tsuda F., Mishiro S.VirologyFull-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes.1992331341Abe K., Inchauspe G., Fujisawa K.J.Gen.Virol.Genomic characterization and mutation rate of hepatitis C virus isolated from a patient who contracted hepatitis during an epidemic of non-A, non-B hepatitis in Japan.199227252729Dansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730Santolini E., Migliaccio G., La Monica N.J.VirologyBiosynthesis and biochemical properties of the hepatitis C virus core protein.199436313641Ray R.B., Ray R.FEMS Microbiol.Lett.Hepatitis C virus core protein: intriguing properties and functional relevance.2001149156Barba G., Harper F., Harada T., Kohara M., Goulinet S., Matsuura Y., Eder G., Schaff Z., Chapman M.J., Miyamura T., Brechot C.Proc.Natl.Acad.Sci.USAHepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets.199712001205Walewski J.L., Gutierrez J.A., Branch-Elliman W., Stump D.D., Keller T.R., Rodriguez A., Benson G., Branch A.D.RNAMutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions.2002557571Chang S.C., Yen J.H., Kang H.Y., Jang M.H., Chang M.F.Biochem.Biophys.Res.Commun.Nuclear localization signals in the core protein of hepatitis C virus.199412841290Kunkel M., Watowich S.J.FEBS Lett.Biophysical characterization of hepatitis C virus core protein: implications for interactions within the virus and host.2004174180
06.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
 1776.170503 1771.058777 virus ion channelCarrere-Kremer S., Montpellier-Pala C., Cocquerel L., Wychowski C., Penin F., Dubuisson J.J.VirologySubcellular localization and topology of the p7 polypeptide of hepatitis C virus.200237203730Pavlovic D., Neville D.C., Argaud O., Blumberg B., Dwek R.A., Fischer W.B., Zitzmann N.Proc.Natl.Acad.Sci.USAThe hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.200361046108Griffin S.D., Beales LP., Clarke D.S., Worsfold O., Evans S.D., Jaeger J., Harris M.P., Rowlands D.J.FEBS Lett.The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.20033438Premkumar A., Wilson L., Ewart G.D., Gage P.W.FEBS Lett.Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride.200499103
19.10.2004;Khlebodarova T.M.;created
19.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
 199.231446 80.825684 1672.545899 1960.533143 black yellow rounded_rect 70 Na+Sodium cation
02.3.2000.;Ignatieva E.V.;created
06.3.2000.;Ignatieva E.V.;updated
 1795.192871 2002.817992 K+Potassium cation
02.3.2000.;Ignatieva E.V.;created
15.12.2002;Ignatieva E.V.;updated
 1754.192871 2002.817992 Ca++Calcium cation (II)
18.10.1999;Alex;created
06.3.2000.;Ignatieva E.V.;updated
 1711.192871 2001.817992 p7p7 proteinHepatitis C virushuman hepatitis C virusactivemultimerGriffin S.D., Beales LP., Clarke D.S., Worsfold O., Evans S.D., Jaeger J., Harris M.P., Rowlands D.J.FEBS Lett.The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.20033438Griffin S.D., Harvey R., Clarke D.S., Barclay W.S., Harris M., Rowlands D.J.J.Gen.Virol.A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria.2004451461
11.11.2004;Khlebodarova T.M.;edited
 1827.323975 1959.439697 NS2Nonstructural protein NS2 P21Hepatitis C virushuman hepatitis C virusactivemonomerYamaga A.K., Ou J.H.J.Biol.Chem.Membrane topology of the hepatitis C virus NS2 protein.20023322833234Santolini E., Pacini L., Fipaldini C., Migliaccio G., Monica N.J.VirologyThe NS2 protein of hepatitis C virus is a transmembrane polypeptide.199574617471Walewski J.L., Gutierrez J.A., Branch-Elliman W., Stump D.D., Keller T.R., Rodriguez A., Benson G., Branch A.D.RNAMutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions.2002557571
20.10.2004;Khlebodarova T.M.;edited
06.10.2004;Khlebodarova T.M.;edited
 1630.146974 1752.087098 IRE1Serine/threonine protein kinase/endoribonuclease IRE1ERN1 Homo sapienshumanSWISS-PROTO75460ERN1_HUMANinactivenon phosphorylatedmonomerTardif K.D., Mori K., Kaufman R.J., Siddiqui A.J.Biol.Chem.Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.20041715817164 1476.000733 2113.651733 regulatory eventincreaseindirectexperimentalTardif K.D., Mori K., Kaufman R.J., Siddiqui A.J.Biol.Chem.Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.20041715817164
25.10.2004;Khlebodarova T.M.;edited
 1563.481202 1991.913452 ERADERA protein degradation
25.10.2004;Khlebodarova T.M.;edited
25.10.2004;Khlebodarova T.M.;created
 1606.555421 2195.921265 no data reactiondirectexperimentalSerine/threonine protein kinase/endoribonuclease IRE1Homo sapienshumanSerine/threonine protein kinase/endoribonuclease IRE1Homo sapienshumanLiu C.Y., Xu Z., Kaufman R.J.J.Biol.Chem.Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.20031768017687Tardif K.D., Mori K., Kaufman R.J., Siddiqui A.J.Biol.Chem.Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.20041715817164
25.10.2004;Khlebodarova T.M.;edited
 1553.207764 2096.776733 p90ATF6Cyclic-AMP-dependent transcription factor ATF-6 betaActivating transcription factor 6 betacAMP response element binding protein-related proteinCreb-rpG13 protein CREBL1Homo sapienshumanSWISS-PROTQ99941AT6B_HUMANinactivemonomerHaze K., Yoshida H., Yanagi H., Yura T., Mori K.Mol.Biol.CellMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.199937873799
25.10.2004;Khlebodarova T.M.;edited
 1379.012451 2020.757080 regulatory eventdecreaseindirectexperimentalSerine/threonine protein kinase/endoribonuclease IRE1Homo sapienshumanTardif K.D., Mori K., Kaufman R.J., Siddiqui A.J.Biol.Chem.Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.20041715817164
25.10.2004;Khlebodarova T.M.;edited
 1609.670656 2129.639526 DDX3DEAD-box protein 3Helicase-like protein 2HLP2DEAD-box, X isoformDDX3XDBXHomo sapienshumanSWISS-PROTO00571DDX3_HUMANactiveno dataMamiya N., Worman H.J.J.Biol.Chem.Hepatitis C virus core protein binds to a DEAD box RNA helicase.19991575115756 1369.437622 1884.688721 IRE1Serine/threonine protein kinase/endoribonuclease IRE1Endoplasmic reticulum-to-nucleus signaling 1ERN1hIRE1pIRE1aInositol-requiring 1Ire1alphaHomo sapienshumanSWISS-PROTO75460ERN1_HUMANactivephosphorylatedhomodimerTardif K.D., Mori K., Kaufman R.J., Siddiqui A.J.Biol.Chem.Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.20041715817164
28.10.2004;Khlebodarova T.M.;edited
 1659.164796 2078.241577 IRE2Serine/threonine protein kinase/endoribonuclease IRE2Inositol-requiring 2Endoplasmic reticulum-to-nucleus signaling 2hIRE2pIRE1bIre1betaERN2Homo sapienshumanSWISS-PROTQ76MJ5ERN2_HUMANactivephosphorylatedno dataIwawaki T., Hosoda A., Okuda T., Kamigori Y., Nomura-Furuwatari C., Kimata Y., Tsuru A., Kohno K.Nat.Cell.Biol.Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.2001158164 1363.358399 2147.981445 E1/E2Envelope glycoprotein E1/E2Hepatitis C virushuman hepatitis C virusactiveglycosylatedheterodimerPenin F., Combet C., Germanidis G., Frainais P.O., Deleage G., Pawlotsky J.M.J.VirologyConservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment.200157035710Deleersnyder V., Pillez A., Wychowski C., Blight K., Xu J., Hahn Y.S., Rice C.M., Dubuisson J.J.VirologyFormation of native hepatitis C virus glycoprotein complexes.1997697704Kurihara C., Tsuzuki Y., Hokari R., Nakashima H., Mataki N., Kuroki M., Kawaguchi A., Nagao S., Kondo T., Miura S. J.Med.Virol.A highly hydrophobic domain within hypervariable region 1 may be related to the entry of hepatitis C virus into cultured human hepatoma cells.2004546555Goffard A., Dubuisson J.BiochimieGlycosylation of hepatitis C virus envelope proteins.2003295301Kaimori A., Kanto T., Kwang Limn C., Komoda Y., Oki C., Inoue M., Miyatake H., Itose I., Sakakibara M., Yakushijin T., Takehara T., Matsuura Y., Hayashi N.VirologyPseudotype hepatitis C virus enters immature myeloid dendritic cells through the interaction with lectin.20047483Op De Beeck A., Voisset C., Bartosch B., Ciczora Y., Cocquerel L., Keck Z., Foung S., Cosset F.L., Dubuisson J.J.VirologyCharacterization of functional hepatitis C virus envelope glycoproteins.200429943002
12.10.2004;Khlebodarova T.M.;edited
26.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
01.11.2004;Khlebodarova T.M.;edited
09.11.2004;Khlebodarova T.M.;edited
22.10.2004;Khlebodarova T.M.;edited
10.11.2004;Khlebodarova T.M.;edited
 1769.597657 1852.732605 regulatory eventdecreasedirectexperimentalNonstructural protein NS4B Hepatitis C virushuman hepatitis C virusPiccininni S., Varaklioti A., Nardelli M., Dave B., Raney K.D., McCarthy J.E.J.Biol.Chem.Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the non-structural (NS) 3 helicase and the NS4B membrane protein.20024567045679
05.10.2004;Khlebodarova T.M.;edited
 1456.240968 1484.446228 regulatory eventincreasedirectexperimentalProtease/helicase NS3 Hepatitis C virushuman hepatitis C virusPiccininni S., Varaklioti A., Nardelli M., Dave B., Raney K.D., McCarthy J.E.J.Biol.Chem.Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the non-structural (NS) 3 helicase and the NS4B membrane protein.20024567045679
05.10.2004;Khlebodarova T.M.;edited
 1516.631593 1295.830993 regulatory eventdecreasedirectexperimentalNonstructural protein NS5AHepatitis C virushuman hepatitis C virusShirota Y., Luo H., Qin W., Kaneko S., Yamashita T., Kobayashi K., Murakami S.J.Biol.Chem.Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity.20021114911155
05.10.2004;Khlebodarova T.M.;created
05.10.2004;Khlebodarova T.M.;edited
 1437.008546 1488.409119 NPpN termini polypeptideHepatitis C virushuman hepatitis C virusinactivemonomerHijikata M., Kato N., Ootsuyama Y., Nakagawa M., Shimotohno K.Proc.Natl.Acad.Sci.USAGene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.199155475551
05.10.2004;Khlebodarova T.M.;created
 2217.341553 1025.184510 reactiondirectexperimentalNonstructural protein NS4AHepatitis C virushuman hepatitis C virusProtease/helicase NS3 Hepatitis C virushuman hepatitis C virusNS3/NS4A complexHepatitis C virushuman hepatitis C virusFailla C., Tomei L., De Francesco R.J.VirologyBoth NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.199437533760
05.10.2004;Khlebodarova T.M.;edited
05.10.2004;Khlebodarova T.M.;created
 1742.981200 910.922792 E1Envelope glycoprotein E1 GP32GP35Hepatitis C virushuman hepatitis C virusinactivemonomerDeleersnyder V., Pillez A., Wychowski C., Blight K., Xu J., Hahn Y.S., Rice C.M., Dubuisson J.J.VirologyFormation of native hepatitis C virus glycoprotein complexes.1997697704 2163.305421 1388.545838 CPpC-terminal polypeptideHepatitis C virushuman hepatitis C virusinactivemonomerGrakoui A., McCourt D.W., Wychowski C., Feinstone S.M., Rice C.M.Proc.Natl.Acad.Sci.USAA second hepatitis C virus-encoded proteinase.19931058310587 1901.888916 1028.578065 regulatory eventondirectexperimentalNS2-3 proteinaseHepatitis C virushuman hepatitis C virusGrakoui A., McCourt D.W., Wychowski C., Feinstone S.M., Rice C.M.Proc.Natl.Acad.Sci.USAA second hepatitis C virus-encoded proteinase.19931058310587
06.10.2004;Khlebodarova T.M.;edited
 2046.347994 985.068010 reactionindirectexperimentalHomo sapienshumanp21 Waf1 kinase inhibitorHomo sapienshumanOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
06.10.2004;Khlebodarova T.M.;edited
 583.520655 1213.702760 regulatory eventdecreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
06.10.2004;Khlebodarova T.M.;edited
 898.542533 1300.190275 ADARDouble-stranded RNA-specific adenosine deaminaseHomo sapienshumanmRNAADARDouble-stranded RNA-specific adenosine deaminase DRADAADAR1DSRADIFI4Homo sapienshuman
06.10.2004;Khlebodarova T.M.;created
 1078.398774 642.562135 2'-5'-OAS2'-5' oligoadenylate synthetaseHomo sapienshumanmRNAOAS12'-5' oligoadenylate synthetaseOIAS2'-5' OASHomo sapienshuman
04.10.2004;Khlebodarova T.M.;created
 1000.097901 603.039980 p21 waf1p21 waf1Homo sapienshumanmRNAU937myelomonocytic cellsHomo sapienshumanLiu M., Iavarone A., Freedman L.P.J.Biol.Chem.Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation.19963172331728
02.2.2000.;Suslov V.V.;created
07.7.2000.;Suslov V.V.;updated
06.3.2001.;Turn;updated
 583.101750 1142.591354 PRKRprotein kinase, interferon-inducible double stranded RNA dependent mRNAPKRHomo sapienshumanmRNAGenBankNM_002759NM_002759PRKRinterferon-inducible dsRNA dependent protein kinaseprotein kinase, interferon-inducible double stranded RNA dependentinterferon-inducible elF2alpha kinasePKREIF2AK1Homo sapienshumanHCVhepatitis C virus
07.10.2004;Ananko E.A.;created
05.12.2004;Ananko E.A.;edited
 790.529541 574.508913 GBP1guanylate binding protein 1, interferon-inducible, 67kDaHomo sapienshumanmRNAEMBLBT006847BT006847GenBankNM_002053NM_002053GBP1guanylate-binding protein 167 kDa guanylate-binding protein 1Interferon-induced guanylate-binding protein 1Guanine nucleotide-binding protein 1Homo sapienshuman
07.10.2004;Khlebodarova T.M.;created
07.10.2004;Khlebodarova T.M.;edited
08.10.2004;Ananko E.A.;edited
 910.060791 583.602663 p53p53 cellular tumor antigenHomo sapienshumanmRNAp53p53 tumor suppressorHomo sapienshuman
07.10.2004;Khlebodarova T.M.;created
 681.844246 1157.780579 reactionindirectexperimentalHomo sapienshumantumor supressor gene productHomo sapienshumanOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
07.10.2004;Khlebodarova T.M.;created
07.10.2004;Khlebodarova T.M.;edited
 674.905770 1227.897767 regulatory eventdecreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
07.10.2004;Khlebodarova T.M.;edited
07.10.2004;Khlebodarova T.M.;created
 899.827645 1280.983736 PCNAPCNAHomo sapienshumanmRNAPCNAproliferating cell nucleolar antigen p120Homo sapienshumanLee H.-H., Chiang W.H., Chiang S.H., Liu Y.C., Hwang J., Ng S.Y.Gene ExpressionRegulation of cyclin D1, DNA topoisomerase I, and proliferating cell nuclear antigen promoters during the cell cycle.199595109
28.01.2002;Turn;created
29.06.2002;Turn;updated
 795.672370 1168.405579 reactionindirectexperimentalHomo sapienshumanproliferating cell nucleolar antigen p120Homo sapienshumanOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
07.10.2004;Khlebodarova T.M.;created
07.10.2004;Khlebodarova T.M.;edited
 780.750495 1237.858704 regulatory eventdecreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
07.10.2004;Khlebodarova T.M.;edited
07.10.2004;Khlebodarova T.M.;created
 1129.358899 1202.634095 c-fosc-fosHomo sapienshumanc-fosc-fos protooncogeneHomo sapienshumaninactiveno datamonomerJEG-3choriocarcinoma cellsHomo sapienshumanAlbanese C, Johnson J, Watanabe G., Eklund N., Vu D., Arnold A., Pestell R.G.J.Biol.Chem.Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions.19952358923597Grosch S., Kaina B.Biochem.Biophys.Res.Commun.Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB1999859863 C-Fos represses the cyclin D1 promoter in Cos and JEG-3 cells [Albanese C. et al., 1995]
13.5.2000.;Stepanenko I.L.;created
27.01.2002;Turn;updated
 780.145029 1375.378235 c-Fosc-Fos protooncogenHomo sapienshumanmRNAEMBLBC004490BC004490c-fosc-fos protooncogeneHomo sapienshuman
07.10.2004;Khlebodarova T.M.;created
 847.625506 1157.233704 reactionindirectexperimentalHomo sapienshumanc-fosHomo sapienshumanOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
07.10.2004;Khlebodarova T.M.;created
07.10.2004;Khlebodarova T.M.;edited
 855.828625 1250.749329 regulatory eventdecreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
07.10.2004;Khlebodarova T.M.;edited
07.10.2004;Khlebodarova T.M.;created
 1114.547375 1217.327454 p53tumor supressor gene productHomo sapienshumanp53p53 tumor suppressorHomo sapienshumaninactivephosphorylatedmultimerp53TF-1pluripotent erythroleukemia cell line TF-1Homo sapienshumanFibroblastFibroblastsHomo sapienshumanMiyashita T., Reed J.C.CellTumor suppressor p53 is a direct transcriptional activator of the human bax gene.1995293299Tsutsumi-Ishii Y., Tadokoro K., Hanaoka F., Tsuchida N.Cell Growth and DifferentiationResponse of heat shock element within of human HSP70 promoter of mutated p53 genes199518
09.10.97;Ananko E.;created
01.12.2000;Grigoriev S.A.;updated
14-Dec-02.;Stepanenko I.L.;updated
 620.052259 1300.300112 Aktprotein kinase BRAC-alpha serine/threonine-protein kinase RACEC 2.7.1.37 RAC-PK-alphaC-AKTPKBAKT1Homo sapienshumanSWISS-PROTP31749KRAC_HUMANactivephosphorylatedmonomer293293 kidney epithelial cellsHomo sapienshumanHeLahuman tumor cell line, epithelial fibroblasts, cervical carcinoma cell lineHomo sapienshumanMCF-7MCF-7 breast cancer cellsHomo sapienshumanJurkatCD4+ T lymphoblastoid cell lineHomo sapienshumanKim A.H., Khursigara G., Sun X., Franke T.F., ChaoM.V.Mol.Cell.Biol.Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1.2001893901 serine/threonine kinases
28-Feb-02.;Alena N.;created
05-Dec-02.;Alena N.;updated
07.10.2004;Khlebodarova T.M.;edited
02.02.2005;Stepanenko I.L.;edited
 2053.406739 672.331392 SK6p70 ribosomal protein S6 kinaseEC 2.7.1.37RPS6KB1p70-S6KHomo sapienshumanSWISS-PROTP23443K6B1_HUMANactivephosphorylatedno dataPullen N., Dennis P.B., Andjelkovic M., Dufner A., Kozma S.C., Hemmings B.A., Thomas G.SciencePhosphorylation and activation of p70s6k by PDK1.1998707710 Activation of the kinase requires hierarchical phosphorylation at multiple sites, culminating in the phosphorylation of the threonine in position 229 (Thr229), in the catalytic domain by PDK1. The phosphorylation of Thr229 appears to depend on phosphorylation of Thr389, and this reaction is facilitated by converting four (Ser/Thr)-Pro phosphorylation sites in the autoinhibitory domain to acidic residues.
06.11.2002;Alena N.;created
07.10.2004;Khlebodarova T.M.;edited
 1992.273937 704.225922 reactiondirectexperimentalNonstructural protein NS5AHepatitis C virushuman hepatitis C virusNon-structural 5A protein Hepatitis C virushuman hepatitis C virusCoito C., Diamond D.L., Neddermann P., Korth M.J., Katze M.G.J.VirologyHigh-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein200435023513
07.10.2004;Khlebodarova T.M.;edited
 1896.707532 633.874360 regulatory eventondirectexperimentalprotein kinase BHomo sapienshumanp70 ribosomal protein S6 kinaseHomo sapienshumanCoito C., Diamond D.L., Neddermann P., Korth M.J., Katze M.G.J.VirologyHigh-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein200435023513
07.10.2004;Khlebodarova T.M.;edited
 1963.113785 665.827477 Translation Translation (protein synthesis)
07.10.2004;Ananko E.A.;created
07.10.2004;Ananko E.A.;edited
17.02.2006;Podkolodnaya O.A.;edited
 838.626224 1694.439850 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4B Hepatitis C virushuman hepatitis C virusKato J., Kato N., Yoshida H., Ono-Nita S.K., Shiratori Y., Omata M.J.Med.Virol.Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo.2002187199
08.10.2004;Khlebodarova T.M.;edited
 1024.441651 1588.489657 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4AHepatitis C virushuman hepatitis C virusKato J., Kato N., Yoshida H., Ono-Nita S.K., Shiratori Y., Omata M.J.Med.Virol.Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo.2002187199
08.10.2004;Khlebodarova T.M.;edited
 1012.496339 1576.212326 regulatory eventincreaseindirectexperimentalNonstructural protein NS4B Hepatitis C virushuman hepatitis C virusHe Y., Yan W., Coito C., Li Y., Gale M. Jr., Katze M.G.J.Gen.Virol.The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins.2003535543NS4B in human liver cells stimulated HCV IRES activity.He Y., Yan W., Coito C., Li Y., Gale M. Jr., Katze M.G.J.Gen.Virol.The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins.2003535543
07.10.2004;Khlebodarova T.M.;edited
08.10.2004;Khlebodarova T.M.;edited
 1502.711436 524.318696 regulatory eventincreaseindirectexperimentalNon-structural 5A protein Hepatitis C virushuman hepatitis C virusHe Y., Yan W., Coito C., Li Y., Gale M. Jr., Katze M.G.J.Gen.Virol.The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins.2003535543NS5A in human liver cells stimulated HCV IRES activity.He Y., Yan W., Coito C., Li Y., Gale M. Jr., Katze M.G.J.Gen.Virol.The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins.2003535543
07.10.2004;Khlebodarova T.M.;edited
08.10.2004;Khlebodarova T.M.;edited
 1655.977051 460.128259 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4AHepatitis C virushuman hepatitis C virusKato J., Kato N., Yoshida H., Ono-Nita S.K., Shiratori Y., Omata M.J.Med.Virol.Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo.2002187199
08.10.2004;Khlebodarova T.M.;edited
 1570.945557 527.423250 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4B Hepatitis C virushuman hepatitis C virusKato J., Kato N., Yoshida H., Ono-Nita S.K., Shiratori Y., Omata M.J.Med.Virol.Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo.2002187199
08.10.2004;Khlebodarova T.M.;edited
 1524.851807 524.298265 apoptosisapoptosisHardingham G.E., Fukunaga Y., Bading H. Nat.Neurosci.Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.2002405414
21.4.2001.;Stepanenko I.L.;created
27.02.2006;Agapova T.Yu.;edited
 1079.856692 1700.387119 regulatory eventdecreaseindirectexperimentalNonstructural protein NS2 Hepatitis C virushuman hepatitis C virusErdtmann L., Franck N., Lerat H., Le Seyec J., Gilot D., Cannie I., Gripon P., Hibner U., Guguen-Guillouzo C.J.Biol.Chem.The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis.20031825618264NS2 specifically bound to CIDE-B and acts as an inhibitor of CIDE-B-induced apaptosis.Erdtmann L., Franck N., Lerat H., Le Seyec J., Gilot D., Cannie I., Gripon P., Hibner U., Guguen-Guillouzo C.J.Biol.Chem.The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis.20031825618264
08.10.2004;Khlebodarova T.M.;edited
 1241.571535 1795.487703 regulatory eventincreasedirectexperimentalNS3/NS4A complexHepatitis C virushuman hepatitis C virusKuang W.F., Lin Y.C., Jean F., Huang Y.W., Tai C.L., Chen D.S., Chen P.J., Hwang L.H.Biochem.Biophys.Res.Commun.Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.2004211217
08.10.2004;Khlebodarova T.M.;edited
 1552.532470 1300.714280 PTBPolypyrimidine tract-binding protein 157 kDa RNA-binding protein PPTB-1Heterogeneous nuclear ribonucleoprotein IhnRNP I PTBP1Homo sapienshumanSWISS-PROTP26599PTB_HUMANactivehomodimerAli N., Siddiqui A.J.VirologyInteraction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.199563676375
26.04.2006;Mishchenko E.L.;edited
 1470.249694 319.088562 regulatory eventincreasedirectexperimentalPolypyrimidine tract-binding protein 1Homo sapienshumanAli N., Siddiqui A.J.VirologyInteraction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.199563676375
08.10.2004;Khlebodarova T.M.;edited
 1519.366884 386.897156 regulatory eventincreaseindirectexperimentalNS2-3 proteinaseHepatitis C virushuman hepatitis C virusLiu Q., Bhat R.A., Prince A.M., Zhang P.Biochem.Biophys.Res.Commun.The hepatitis C virus NS2 protein generated by NS2-3 autocleavage is required for NS5A phosphorylation.1999572577NS5A, when released from the NS2-5 polyprotein, is phosphorylated as two distinct forms, pp56 and pp58. Appearance of pp58 requires NS2 in cis, while pp56 is NS2 independent.Liu Q., Bhat R.A., Prince A.M., Zhang P.Biochem.Biophys.Res.Commun.The hepatitis C virus NS2 protein generated by NS2-3 autocleavage is required for NS5A phosphorylation.1999572577
08.10.2004;Khlebodarova T.M.;edited
 1992.023134 823.379457 NSAP1NS1-associated protein 1 hnRNP Q hnRNP-Q Synaptotagmin binding, cytoplasmic RNA interacting protein Glycine-and tyrosine-rich RNA binding protein GRY-RBPHeterogeneous nuclear ribonucleoprotein Q SYNCRIPHNRPQHomo sapienshumanSWISS-PROTO60506ROQ_HUMAN activemonomerKim J.H., Paek K.Y., Ha S.H., Cho S., Choi K., Kim C.S., Ryu S.H., Jang S.K.Mol.Cell.Biol.A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon.200478787890 1540.485535 306.376619 regulatory eventincreasedirectexperimentalNS1-associated protein 1 Homo sapienshumanKim J.H., Paek K.Y., Ha S.H., Cho S., Choi K., Kim C.S., Ryu S.H., Jang S.K.Mol.Cell.Biol.A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon.200478787890
08.10.2004;Khlebodarova T.M.;edited
 1554.407410 394.876619 PCNAproliferating cell nucleolar antigen p120Homo sapienshumanPCNAproliferating cell nucleolar antigen p120Homo sapienshumanactiveno datano dataLee H.-H., Chiang W.H., Chiang S.H., Liu Y.C., Hwang J., Ng S.Y.Gene ExpressionRegulation of cyclin D1, DNA topoisomerase I, and proliferating cell nuclear antigen promoters during the cell cycle.199595109
28.01.2002;Turn;created
29.06.2002;Turn;updated
 705.975108 1335.378267 20Sp20S proteasomeHomo sapienshumanactivemultimerKhu Y.L., Tan Y.J., Lim S.G., Hong W., Goh P.Y.Biochem.J.Hepatitis C Virus nonstructural protein NS3 interacts with LMP7, a component of immunoproteasome, and affects its proteasome activity.2004133 2558.560486 744.063356 20Sip20S immunoproteasomeHomo sapienshumanactivemultimerKhu Y.L., Tan Y.J., Lim S.G., Hong W., Goh P.Y.Biochem.J.Hepatitis C Virus nonstructural protein NS3 interacts with LMP7, a component of immunoproteasome, and affects its proteasome activity.2004133 2447.404358 812.389528 reactionindirectexperimental20S proteasomeHomo sapienshuman20S immunoproteasomeHomo sapienshumanKhu Y.L., Tan Y.J., Lim S.G., Hong W., Goh P.Y.Biochem.J.Hepatitis C Virus nonstructural protein NS3 interacts with LMP7, a component of immunoproteasome, and affects its proteasome activity.2004133
11.10.2004;Khlebodarova T.M.;edited
 2581.472718 853.139863 IFN-gammainterferon-gammaIMMUNE INTERFERONHomo sapienshumanSWISS-PROTP01579ING_HUMANIFN-gammainterferon-gammaHomo sapienshumanactiveno datamultimercorticosteroidsprostaglandinsPMA/ionomycinB-cellB-lymphocytesHomo sapienshumanJurkatCD4+ T lymphoblastoid cell lineHomo sapienshumanT-cellT-lymphocytesHomo sapienshumanAjjan R.A., Kamaruddin N.A., Crisp M., Watson P.F., Ludgate M., Weetman A.P..Clin.Endocrinol.(Oxf.)Regulation and tissue distribution of the human sodium iodide symporter gene.1998517523Kasai K., Banba N., Motohashi S., Hattori Y., Manaka K., Shimoda S.I..FEBS Lett.Expression of monocyte chemoattractant protein-1 mRNA and protein in cultured human thyrocytes.1996137140 cytokine Length: 166 AA [unprocessed precursor] Molecular weight: 19348 Da [-//-] Tetramer with molecular weight of monomer-17 kDa. IFN-gamma by itself is a weak stimulant of MCP-1 in thyrocytes, but has a synergistic stimulatory activity with either IL-1 or TNF-alpha (Kasai K. et al., 1996).
09.10.97;Ananko E.;created
16.02.2001;Nedosekina E.A.;updated
26-Jul-02.;Suslov V.V.;updated
 2467.670471 680.433808 regulatory eventincreaseindirectexperimentalinterferon-gammaHomo sapienshumanKhu Y.L., Tan Y.J., Lim S.G., Hong W., Goh P.Y.Biochem.J.Hepatitis C Virus nonstructural protein NS3 interacts with LMP7, a component of immunoproteasome, and affects its proteasome activity.2004133
11.10.2004;Khlebodarova T.M.;edited
 2514.265197 793.284394 Protein degradationProtein degradation
21.4.2000.;Tana;created
05.05.2005;Ananko E.A.;edited
 2554.324280 1060.171144 reactiondirectexperimental20S immunoproteasomeHomo sapienshumanKhu Y.L., Tan Y.J., Lim S.G., Hong W., Goh P.Y.Biochem.J.Hepatitis C Virus nonstructural protein NS3 interacts with LMP7, a component of immunoproteasome, and affects its proteasome activity.2004133
11.10.2004;Khlebodarova T.M.;edited
 2505.456604 954.651582 regulatory eventdecreaseindirectexperimentalProtease/helicase NS3 Hepatitis C virushuman hepatitis C virusKhu Y.L., Tan Y.J., Lim S.G., Hong W., Goh P.Y.Biochem.J.Hepatitis C Virus nonstructural protein NS3 interacts with LMP7, a component of immunoproteasome, and affects its proteasome activity.2004133The presence of the NS3 HCV protein specifically inhibit the immunoproteasomes and not the constitutive proteasomes as reduction in peptidase activities were only observed with the addition of IFN-gamma. NS3 interacs with LMP7 subunit of 20S immunoproteasome.Khu Y.L., Tan Y.J., Lim S.G., Hong W., Goh P.Y.Biochem.J.Hepatitis C Virus nonstructural protein NS3 interacts with LMP7, a component of immunoproteasome, and affects its proteasome activity.2004133
11.10.2004;Khlebodarova T.M.;edited
 2038.400941 855.144745 reactiondirectexperimentalC-terminal polypeptideHepatitis C virushuman hepatitis C virusNS2-3 proteinaseHepatitis C virushuman hepatitis C virusProtease/helicase NS3 Hepatitis C virushuman hepatitis C virusNonstructural protein NS4AHepatitis C virushuman hepatitis C virusNonstructural protein NS4B Hepatitis C virushuman hepatitis C virusNonstructural protein NS5AHepatitis C virushuman hepatitis C virusNonstructural protein NS5BHepatitis C virushuman hepatitis C virusFailla C., Tomei L., De Francesco R.J.VirologyBoth NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.199437533760
11.10.2004;Khlebodarova T.M.;created
11.10.2004;Khlebodarova T.M.;edited
 1805.310119 1243.615968 reactiondirectexperimentalHepatitis C polyproteinHepatitis C virushuman hepatitis C virusC-terminal polypeptideHepatitis C virushuman hepatitis C virusN termini polypeptideHepatitis C virushuman hepatitis C virusWang W., Lahser F.C., Yi .M., Wright-Minogue J., Xia E., Weber P.C., Lemon S.M., Malcolm B.A.J.VirologyConserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition.2004700709Grakoui A., McCourt D.W., Wychowski C., Feinstone S.M., Rice C.M.Proc.Natl.Acad.Sci.USAA second hepatitis C virus-encoded proteinase.19931058310587Hijikata M., Mizushima H., Tanji Y., Komoda Y., Hirowatari Y., Akagi T., Kato N., Kimura K., Shimotohno K.Proc.Natl.Acad.Sci.USAProteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus.19931077310777
06.10.2004;Khlebodarova T.M.;edited
 2060.390017 921.583926 regulatory eventondirectexperimentalNS3/NS4A complexHepatitis C virushuman hepatitis C virusFailla C., Tomei L., De Francesco R.J.VirologyBoth NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.199437533760
11.10.2004;Khlebodarova T.M.;created
11.10.2004;Khlebodarova T.M.;edited
 1751.646790 1150.071045 NS2-3NS2-3 proteinaseHepatitis C virushuman hepatitis C virusactivemonomerShoji I., Suzuki T., Sato M., Aizaki H., Chiba T., Matsuura Y., Miyamura T.VirologyInternal processing of hepatitis C virus NS3 protein.1999315323Grakoui A., McCourt D.W., Wychowski C., Feinstone S.M., Rice C.M.Proc.Natl.Acad.Sci.USAA second hepatitis C virus-encoded proteinase.19931058310587
11.10.2004;Khlebodarova T.M.;edited
 1961.246924 1092.299455 SSBSjogren syndrome type B antigenLa autoantigenLupus La protein SS-BLa ribonucleoproteinHomo sapienshumanSWISS-PROTP05455LA_HUMAN activephosphorylatedmonomerPudi R., Abhiman S., Srinivasan N., Das S.J.Biol.Chem.Hepatitis C virus internal ribosome entry site-mediated translation is stimulated by specific interaction of independent regions of human La autoantigen.20031223112240Pudi R., Srinivasan P., Das S.J.Biol.Chem.La protein binding at the GCAC site near the initiator AUG facilitates the ribosomal assembly on the hepatitis C virus RNA to influence internal ribosome entry site-mediated translation.20042987929888Izumi R.E., Das S., Barat B., Raychaudhuri S., Dasgupta A.J.VirologyA peptide from autoantigen La blocks poliovirus and hepatitis C virus cap-independent translation and reveals a single tyrosine critical for La RNA binding and translation stimulation.200437633776Ali N., Siddiqui A.J.VirologyInteraction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.199563676375Costa-Mattioli M., Svitkin Y., Sonenberg N.Mol.Cell.Biol.La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro.200468616870
07.10.2004;Khlebodarova T.M.;edited
11.10.2004;Khlebodarova T.M.;edited
12.10.2004;Khlebodarova T.M.;edited
 1610.723146 311.741547 eIF2alphaalpha -subunit of eukaryotic initiation factor 2Homo sapienshumaninactivephosphorylatedno dataUma S., Yun B.G., Matts R.L.J.Biol.Chem.The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases.20011487514883
09.12.2004;Ananko E.A.;edited
17-Jun-02.;Alena N.;created
 1724.430192 382.444997 eIF2alphaalpha -subunit of eukaryotic initiation factor 2Homo sapienshumanactivenon phosphorylatedno dataUma S., Yun B.G., Matts R.L.J.Biol.Chem.The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases.20011487514883
14.10.2004;Khlebodarova T.M.;edited
17-Jun-02.;Alena N.;created
 2105.699725 393.624684 irreversible reactiondirectexperimentaldsRNA-dependent cAMP-independent protein serine/threonine kinaseHomo sapienshumandsRNA-dependent cAMP-independent protein serine/threonine kinaseHomo sapienshumanTaylor D.R., Lee S.B., Romano P.R., Marshak D.R., Hinnebusch A.G., Esteban M., Mathews M.B.Mol.Cell.Biol.Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.199662956302
14.10.2004;Khlebodarova T.M.;edited
 1859.842302 290.300465 no data regulatory eventdecreasedirectexperimentalHepatitis C virushuman hepatitis C virusVyas J., Elia A., Clemens M.J.RNAInhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNA.2003858870
14.10.2004;Khlebodarova T.M.;edited
 1501.735108 243.621155 no data reactiondirectexperimentalalpha -subunit of eukaryotic initiation factor 2Homo sapienshumanalpha -subunit of eukaryotic initiation factor 2Homo sapienshumanClemens M.J.Prog.Mol.Subcell.Biol.Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis.20015789
14.10.2004;Khlebodarova T.M.;edited
 1952.250733 375.511780 regulatory eventdecreasedirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusTanaka Y., Shimoike T., Ishii K., Suzuki R., Suzuki T., Ushijima H., Matsuura Y., Miyamura T.VirologySelective binding of hepatitis C virus core protein to synthetic oligonucleotides corresponding to the 5' untranslated region of the viral genome.2000229236
14.10.2004;Khlebodarova T.M.;edited
 1439.687746 300.596619 regulatory eventincreasedirectexperimentalEukaryotic translation initiation factor 3Homo sapienshumanSizova D.V., Kolupaeva V.G., Pestova T.V., Shatsky I.N., Hellen C.U.J.VirologySpecific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.199847754782
14.10.2004;Khlebodarova T.M.;edited
 1646.985597 503.621033 regulatory eventincreasedirectexperimental40S ribosomal protein S5Homo sapienshumanFukushi S., Okada M., Stahl J., Kageyama T., Hoshino F.B., Katayama K.J.Biol.Chem.Ribosomal protein S5 interacts with the internal ribosomal entry site of hepatitis C virus.20012082420826
14.10.2004;Khlebodarova T.M.;edited
 1630.188722 403.621033 PKAprotein kinase AcAMP-dependent protein kinase AHomo sapienshumanSWISS-PROTO43741AAKB2_HUMANSWISS-PROTQ13131AAPK1_HUMANSWISS-PROTP54646AAPK2_HUMANQ9Y478AAKB1_HUMANinactivemultimerRossmeisl M., Flachs P., Brauner P., Sponarova J., Matejkova O., Prazak T., Ruzickova J., Bardova K., Kuda O., Kopecky J. Int.J.Obes.Relat.Metab.Disord. Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores. 20043844The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
20.06.2003.;Voronich;created
02.06.2005;Kouznetsova T.N.;edited
19.10.2005;Kouznetsova T.N.;edited
 1244.398926 863.109619 rpS540S ribosomal protein S5Homo sapienshumanSWISS-PROTP46782RS5_HUMANactivemonomerFukushi S., Okada M., Stahl J., Kageyama T., Hoshino F.B., Katayama K.J.Biol.Chem.Ribosomal protein S5 interacts with the internal ribosomal entry site of hepatitis C virus.20012082420826
14.10.2004;Khlebodarova T.M.;edited
 1673.188722 338.402283 PKAprotein kinase AcAMP-dependent protein kinase AHomo sapienshumanSWISS-PROTQ13131AAPK1_HUMANSWISS-PROTP54646AAPK2_HUMANactiveheterodimerBorowski P., Heiland M., Oehlmann K., Becker B., Kornetzky L., Feucht H., Laufs R.Eur.J.Biochem.Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.1996611618The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
14.10.2004;Khlebodarova T.M.;edited
02.06.2005;Kouznetsova T.N.;edited
20.06.2003.;Voronich;created
17.10.2005;Kouznetsova T.N.;edited
 1197.406741 1037.718994 reversible reactiondirectexperimentalprotein kinase AHomo sapienshumanprotein kinase AHomo sapienshumanBorowski P., Heiland M., Oehlmann K., Becker B., Kornetzky L., Feucht H., Laufs R.Eur.J.Biochem.Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.1996611618
14.10.2004;Khlebodarova T.M.;edited
 1258.695801 957.254150 regulatory eventdecreasedirectexperimentalProtease/helicase NS3 Hepatitis C virushuman hepatitis C virusBorowski P., Heiland M., Oehlmann K., Becker B., Kornetzky L., Feucht H., Laufs R.Eur.J.Biochem.Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.1996611618
14.10.2004;Khlebodarova T.M.;edited
 1360.983400 859.230469 regulatory eventdecreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusRay R.B., Steele R., Meyer K., Ray R.J.Biol.Chem.Transcriptional repression of p53 promoter by hepatitis C virus core protein.19971098310986
14.10.2004;Khlebodarova T.M.;edited
 902.089602 1268.800720 TNF-alphatumor necrosis factor-alphaHomo sapienshumanmRNA
03.10.2000;Nedosekina E.A.;created
11-Dec-01.;Suslov V.V.;updated
 906.367678 1191.706848 FECHferrochelataseProtoheme ferro-lyaseFCHHeme synthetaseHomo sapienshumanmRNAFCHferrochelataseHomo sapienshuman
06.10.2004;Khlebodarova T.M.;created
06.10.2004;Khlebodarova T.M.;edited
15.10.2004;Khlebodarova T.M.;edited
 982.930178 1183.666077 regulatory eventdecreaseindirectexperimentalNonstructural protein NS2 Hepatitis C virushuman hepatitis C virusDumoulin F.L., von dem Bussche A., Li J., Khamzina L., Wands J.R., Sauerbruch T., Spengler U.VirologyHepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines.2003260266
15.10.2004;Khlebodarova T.M.;edited
 1244.383303 1772.620850 regulatory eventdecreaseindirectexperimentalNonstructural protein NS2 Hepatitis C virushuman hepatitis C virusDumoulin F.L., von dem Bussche A., Li J., Khamzina L., Wands J.R., Sauerbruch T., Spengler U.VirologyHepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines.2003260266
15.10.2004;Khlebodarova T.M.;edited
 1257.758303 1747.495850 reversible reactiondirectexperimentalProtease/helicase NS3 Hepatitis C virushuman hepatitis C virusProtease/helicase NS3 Hepatitis C virushuman hepatitis C virusMuramatsu S., Ishido S., Fujita T., Itoh M., Hotta H.J.VirologyNuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.199749544961
15.10.2004;Khlebodarova T.M.;edited
 1358.758303 824.394226 p53tumor supressor gene productHomo sapienshumanp53p53 tumor suppressorHomo sapienshumanactivephosphorylatedmultimergamma radiationgamma-irradiationheat shockhydrogen peroxideH2O2UV-irradiationUV-lighthypoxiaTF-1pluripotent erythroleukemia cell line TF-1Homo sapienshumanFibroblastFibroblastsHomo sapienshumanBuschmann T., Potapova O., Bar-Shira A., Ivanov V.N., Fuchs S.Y., Henderson S., Fried V.A., Minamoto T., Alarcon-Vargas D., Pincus M.R., Gaarde W.A., Holbrook N.J., Shiloh Y., Ronai Z.Mol.Cell.Biol.Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.200127432754Di Leonardo A., Linke S.P., Clarkin K., and Wahl G.M.Genes Dev.DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.199425402551Miyashita T., Reed J.C.CellTumor suppressor p53 is a direct transcriptional activator of the human bax gene.1995293299Tsutsumi-Ishii Y., Tadokoro K., Hanaoka F., Tsuchida N.Cell Growth and DifferentiationResponse of heat shock element within of human HSP70 promoter of mutated p53 genes199518
09.10.97;Ananko E.;created
24.11.2000;Grigoriev S.A.;updated
08.01.2002;Turn;updated
05-Apr-02.;Alena N.;updated
14-Dec-02.;Stepanenko I.L.;updated
 1329.398928 689.644287 regulatory eventincreaseindirectexperimentaltumor supressor gene productHomo sapienshumanMuramatsu S., Ishido S., Fujita T., Itoh M., Hotta H.J.VirologyNuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.199749544961
15.10.2004;Khlebodarova T.M.;edited
 1344.320803 779.644226 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4AHepatitis C virushuman hepatitis C virusMuramatsu S., Ishido S., Fujita T., Itoh M., Hotta H.J.VirologyNuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.199749544961
15.10.2004;Khlebodarova T.M.;edited
 1598.445803 900.081726 reactionindirectexperimentalproliferating cell nucleolar antigen p120Homo sapienshumanHomo sapienshumanOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
07.10.2004;Khlebodarova T.M.;created
07.10.2004;Khlebodarova T.M.;edited
 759.632339 1115.954438 p53mutantmutant tumor supressor gene productHomo sapienshumanp53p53 tumor suppressorHomo sapienshumaninactiveno datamultimerFourie A.M., Hupp T.R., Lane D.P., Sang B.C., Barbosa M.S., Sambrook J.F., Gething M.J.J.Biol.Chem.HSP70 binding sites in the tumor suppressor protein p5319971947119479Tsutsumi-Ishii Y., Tadokoro K., Hanaoka F., Tsuchida N.Cell Growth and DifferentiationResponse of heat shock element within of human HSP70 promoter of mutated p53 genes199518
09.10.97;Ananko E.;created
05.6.2000.;Stepanenko I.L.;updated
 1235.570803 745.769226 regulatory eventdecreaseindirectexperimentalmutant tumor supressor gene productHomo sapienshumanMuramatsu S., Ishido S., Fujita T., Itoh M., Hotta H.J.VirologyNuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.199749544961
15.10.2004;Khlebodarova T.M.;edited
 1323.695803 782.144226 regulatory eventdecreasedirectexperimentalEnvelope glycoprotein E2 Hepatitis C virushuman hepatitis C virusTaylor D.R., Shi S.T., Romano P.R., Barber G.N., Lai M.M.ScienceInhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.1999107110
14.10.2004;Khlebodarova T.M.;edited
 2309.569094 1019.169740 regulatory eventincreasedirectexperimentalPolypyrimidine tract-binding protein 1Homo sapienshumanTsuchihara K., Tanaka T., Hijikata M., Kuge S., Toyoda H., Nomoto A., Yamamoto N., Shimotohno K.J.VirologySpecific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X.199767206726Ito T., Lai M.M.J.VirologyDetermination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.199786988706
15.10.2004;Khlebodarova T.M.;edited
 1368.019776 467.940735 irreversible reactionindirectexperimentalHepatitis C virushuman hepatitis C virusHepatitis C virushuman hepatitis C virusBartenschlager R., Lohmann V.J.General Virol.Replication of hepatitis C virus.200016311648Friebe P., Bartenschlager R.J.VirologyGenetic analysis of sequences in the 3' nontranslated region of hepatitis C virus that are important for RNA replication.200253265338
11.10.2004;Khlebodarova T.M.;edited
11.10.2004;Khlebodarova T.M.;created
15.10.2004;Khlebodarova T.M.;edited
 1360.240786 593.019410 regulatory eventdecreasedirectexperimentalNon-structural 5A protein Hepatitis C virushuman hepatitis C virusGale M. Jr., Blakely C.M., Kwieciszewski B., Tan S.L., Dossett M., Tang N.M., Korth M.J., Polyak S.J., Gretch D.R., Katze M.G.Mol.Cell.Biol.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.199852085218Pflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655
14.10.2004;Khlebodarova T.M.;created
14.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
 1854.337647 359.339905 reactionindirectexperimentalc-fos protooncogeneHomo sapienshumanHomo sapienshumanOka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438
07.10.2004;Khlebodarova T.M.;edited
07.10.2004;Khlebodarova T.M.;created
 786.743664 1107.265932 Lmp2Proteasome subunit beta type 9PSMB9 Macropain chain 7Proteasome chain 7Low molecular mass protein 2RING12 proteinMulticatalytic endopeptidase complex chain 7Homo sapienshumanmRNALMP2Proteasome subunit beta type 9 Proteasome chain 7Macropain chain 7Multicatalytic endopeptidase complex chain 7RING12 proteinLow molecular mass protein 2 PSMB9RING12Homo sapienshuman
18.10.2004;Khlebodarova T.M.;created
 575.957520 617.731262 GBP2Interferon-induced guanylate-binding protein 2 Guanine nucleotide-binding protein 2HuGBP-2GTP-binding protein 2Homo sapienshumanmRNAGBP2GTP-binding protein 2Interferon-induced guanylate-binding protein 2 Guanine nucleotide-binding protein 2 HuGBP-2Homo sapienshumandsRNAHuh-7human hepatoma cell lineHomo sapienshumanPflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655 685.262208 586.660950 irreversible reactionindirectexperimentalProteasome subunit beta type 9 Homo sapienshumanHomo sapienshumanPflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655
18.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;created
 619.746583 785.192200 regulatory eventincreaseindirectexperimentalHepatitis C virushuman hepatitis C virusPflugheber J., Fredericksen B., Sumpter R. Jr., Wang C., Ware F., Sodora D.L., Gale M. Jr.Proc.Natl.Acad.Sci.USARegulation of PKR and IRF-1 during hepatitis C virus RNA replication.200246504655
18.10.2004;Khlebodarova T.M.;created
18.10.2004;Khlebodarova T.M.;edited
 1043.699708 795.645325 PKRdsRNA-dependent cAMP-independent protein serine/threonine kinaseInterferon-inducible RNA-dependent protein kinaseP1/eIF-2A protein kinasedsRNA-dependent eIF-2alpha protein kinasep68 kinaseTIK proteinInterferon-induced, double-stranded RNA-activated protein kinaseHomo sapienshumanSWISS-PROTP19525E2K2_HUMANactivephosphorylatedhomodimerIFN-betavirus infectiondsRNAIFN-gammaT-cellT-lymphocytesHomo sapienshumanMacrophageMacrophagesHomo sapienshumanFibroblastFibroblastsHomo sapienshumanClemens M.J., Elia A.J.Interferon Cytokine Res.The double-stranded RNA-dependent protein kinase PKR: structure and function.1997503524Hiasa Y., Kamegaya Y., Nuriya H., Onji M., Kohara M., Schmidt E.V., Chung R.T.Am.J.Gastroenterol.Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.200325282534Gale M. Jr., Blakely C.M., Kwieciszewski B., Tan S.L., Dossett M., Tang N.M., Korth M.J., Polyak S.J., Gretch D.R., Katze M.G.Mol.Cell.Biol.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.199852085218Activation of PKR catalytic function proceeds through a process of dsRNA binding, dimerization, and autophosphorylation.Clemens M.J., Elia A.J.Interferon Cytokine Res.The double-stranded RNA-dependent protein kinase PKR: structure and function.1997503524Constitutive repression of PKR induces malignant transformation of mammalian cells.Gale M. Jr., Blakely C.M., Kwieciszewski B., Tan S.L., Dossett M., Tang N.M., Korth M.J., Polyak S.J., Gretch D.R., Katze M.G.Mol.Cell.Biol.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.199852085218
30.09.2004;Ananko E.A.;edited
01.10.2004;Ananko E.A.;edited
04.10.2004;Ananko E.A.;edited
09.10.97;Ananko E.;created
18.10.2004;Khlebodarova T.M.;edited
 1965.043475 248.425465 PKRdsRNA-dependent cAMP-independent protein serine/threonine kinaseInterferon-induced, double-stranded RNA-activated protein kinasedsRNA-dependent eIF-2alpha protein kinasep68 kinaseInterferon-inducible RNA-dependent protein kinaseP1/eIF-2A protein kinaseTIK proteinHomo sapienshumanSWISS-PROTP19525E2K2_HUMANinactivenone-modifiedmonomerIFN-gammavirus infectionIFN-alphaIFN-betaT-cellT-lymphocytesHomo sapienshumanMacrophageMacrophagesHomo sapienshumanHuh-7human hepatoma cell lineHomo sapienshumanFibroblastFibroblastsHomo sapienshumanHiasa Y., Kamegaya Y., Nuriya H., Onji M., Kohara M., Schmidt E.V., Chung R.T.Am.J.Gastroenterol.Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.200325282534Yan W., Lee H., Yi E.C., Reiss D., Shannon P., Kwieciszewski B.K., Coito C., Li X.J., Keller A., Eng J., Galitski T., Goodlett D.R., Aebersold R., Katze M.G.Genome Biol.System-based proteomic analysis of the interferon response in human liver cells.2004115Yu S.H., Nagayama K., Enomoto N., Izumi N., Marumo F., Sato C.HepatologyIntrahepatic mRNA expression of interferon-inducible antiviral genes in liver diseases: dsRNA-dependent protein kinase overexpression and RNase L inhibitor suppression in chronic hepatitis C.200010891095Gale M. Jr., Blakely C.M., Kwieciszewski B., Tan S.L., Dossett M., Tang N.M., Korth M.J., Polyak S.J., Gretch D.R., Katze M.G.Mol.Cell.Biol.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.199852085218
01.10.2004;Ananko E.A.;edited
18.10.2004;Khlebodarova T.M.;edited
09.10.97;Ananko E.;created
04.12.2004;Ananko E.A.;edited
05.12.2004;Ananko E.A.;edited
 1822.570817 198.894216 regulatory eventdecreaseindirectexperimentalinterferon-alphaHomo sapienshumanBlight K.J., Kolykhalov A.A., Rice C.M.ScienceEfficient initiation of HCV RNA replication in cell culture.200019721974Frese M., Pietschmann T., Moradpour D., Haller O., Bartenschlager R.J.Gen.Virol.Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway.2003723733
18.10.2004;Khlebodarova T.M.;edited
 1013.839968 256.511047 regulatory eventdecreasedirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusShimoike T., Mimori S., Tani H., Matsuura Y., Miyamura T.J.VirologyInteraction of hepatitis C virus core protein with viral sense RNA and suppression of its translation.199997189725
14.10.2004;Khlebodarova T.M.;edited
 1482.785646 517.087402 NS4ANonstructural protein NS4AP4Hepatitis C virushuman hepatitis C virusactivemonomerLin C., Wu J.W., Hsiao K., Su M.S.J.VirologyThe hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins.199764656471Failla C., Tomei L., De Francesco R.J.VirologyBoth NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.199437533760
05.10.2004;Khlebodarova T.M.;created
18.10.2004;Khlebodarova T.M.;edited
 1836.690186 986.046814 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4B Hepatitis C virushuman hepatitis C virusFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131
18.10.2004;Khlebodarova T.M.;edited
 1028.936159 1509.759888 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4AHepatitis C virushuman hepatitis C virusFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131
18.10.2004;Khlebodarova T.M.;edited
 900.826784 1331.181763 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4AHepatitis C virushuman hepatitis C virusFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131
18.10.2004;Khlebodarova T.M.;edited
 898.990847 1315.507935 RNaseLRibonuclease L2-5A-dependent RNaseRibonuclease 42-5A-dependent ribonucleaseRNS4Homo sapienshumanSWISS-PROTQ05823RN5A_HUMANactivehomodimerIFN-alphaFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131
04.12.2004;Ananko E.A.;edited
09.12.2004;Ananko E.A.;edited
 408.151002 1399.195374 RNASEL2-5A-dependent RNaseRNS4Homo sapienshumanmRNARNaseLRibonuclease L2-5A-dependent RNaseRibonuclease 42-5A-dependent ribonucleaseRNS4Homo sapienshumanRNASEL2-5A-dependent ribonucleaseRNS4Homo sapienshumanFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131 486.339479 1107.358582 irreversible reactionindirectexperimentalHomo sapienshumanRibonuclease LHomo sapienshumanFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131
18.10.2004;Khlebodarova T.M.;edited
 434.053346 1322.658447 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4B Hepatitis C virushuman hepatitis C virusFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131
18.10.2004;Khlebodarova T.M.;edited
 1012.803347 1543.314636 regulatory eventdecreaseindirectexperimentalNonstructural protein NS4AHepatitis C virushuman hepatitis C virusFlorese R.H., Nagano-Fujii M., Iwanaga Y., Hidajat R., Hotta H.Virus Res.Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.2002119131
18.10.2004;Khlebodarova T.M.;edited
 1020.865847 1527.134827 p7Protein P7Hepatitis C virushuman hepatitis C virusinactivemonomerLin C., Lindenbach B.D., Pragai B.M., McCourt D.W., Rice C.M.J.VirologyProcessing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini.199450635073Premkumar A., Wilson L., Ewart G.D., Gage P.W.FEBS Lett.Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride.200499103Sakai A., Claire M.S., Faulk K., Govindarajan S., Emerson S.U., Purcell R.H., Bukh J.Proc.Natl.Acad.Sci.USAThe p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences.20031164611651Carrere-Kremer S., Montpellier-Pala C., Cocquerel L., Wychowski C., Penin F., Dubuisson J.J.VirologySubcellular localization and topology of the p7 polypeptide of hepatitis C virus.200237203730Pavlovic D., Neville D.C., Argaud O., Blumberg B., Dwek R.A., Fischer W.B., Zitzmann N.Proc.Natl.Acad.Sci.USAThe hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.200361046108Griffin S.D., Beales LP., Clarke D.S., Worsfold O., Evans S.D., Jaeger J., Harris M.P., Rowlands D.J.FEBS Lett.The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.20033438
19.10.2004;Khlebodarova T.M.;edited
 2328.049074 1495.277466 irreversible reactiondirectexperimentalN termini polypeptideHepatitis C virushuman hepatitis C viruscore proteinHepatitis C virushuman hepatitis C virusF proteinHepatitis C virushuman hepatitis C virusEnvelope glycoprotein E1 Hepatitis C virushuman hepatitis C virusEnvelope glycoprotein E2 Hepatitis C virushuman hepatitis C virusProtein P7Hepatitis C virushuman hepatitis C virusNonstructural protein NS2 Hepatitis C virushuman hepatitis C virusGrakoui A., Wychowski C., Lin C., Feinstone S.M., Rice C.M.J.VirologyExpression and identification of hepatitis C virus polyprotein cleavage products.199313851395Carrere-Kremer S., Montpellier C., Lorenzo L., Brulin B., Cocquerel L., Belouzard S., Penin F., Dubuisson J.J.Biol.Chem.Regulation of hepatitis C virus polyprotein processing by signal peptidase involves structural determinants at the p7 sequence junctions.20044138441392Hijikata M., Kato N., Ootsuyama Y., Nakagawa M., Shimotohno K.Proc.Natl.Acad.Sci.USAGene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.199155475551
19.10.2004;Khlebodarova T.M.;created
19.10.2004;Khlebodarova T.M.;edited
 1894.066652 1479.559204 no data reactiondirectexperimentalcore proteinHepatitis C virushuman hepatitis C viruscore proteinHepatitis C virushuman hepatitis C virusRay R.B., Ray R.FEMS Microbiol.Lett.Hepatitis C virus core protein: intriguing properties and functional relevance.2001149156
19.10.2004;Khlebodarova T.M.;created
19.10.2004;Khlebodarova T.M.;edited
 1648.481569 1464.485595 irreversible reactionindirectexperimentalHepatitis C virushuman hepatitis C virusHepatitis C virushuman hepatitis C virusKolykhalov A.A., Mihalik K., Feinstone S.M., Rice C.M.J.VirologyHepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo.200020462051Friebe P., Lohmann V., Krieger N., Bartenschlager R.J.VirologySequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.20011204712057Bartenschlager R., Lohmann V.J.General Virol.Replication of hepatitis C virus.200016311648Pietschmann T., Lohmann V., Rutter G., Kurpanek K., Bartenschlager R.J.VirologyCharacterization of cell lines carrying self-replicating hepatitis C virus RNAs.200112521264El-Hage N., Luo G.J.Gen.Virol.Replication of hepatitis C virus RNA occurs in a membrane-bound replication complex containing nonstructural viral proteins and RNA.200327612769Lohmann V., Korner F., Koch J., Herian U., Theilmann L., Bartenschlager R.ScienceReplication of subgenomic hepatitis C virus RNAs in a hepatoma cell line.1999110113Miyanari Y., Hijikata M., Yamaji M., Hosaka M., Takahashi H., Shimotohno K.J.Biol.Chem.Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication.20035030150308Lohmann V., Korner F., Dobierzewska A., Bartenschlager R.J.VirologyMutations in hepatitis C virus RNAs conferring cell culture adaptation.200114371449Hardy R.W., Marcotrigiano J., Blight K.J., Majors J.E., Rice C.M.J.VirologyHepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells.200320292037Ahlquist P., Noueiry A.O., Lee W.M., Kushner D.B., Dye B.T.J.VirologyHost factors in positive-strand RNA virus genome replication.200381818186The HCV replication complex (RE) is assembled within membrane srtructures. HCV RNA in the membrane-bound RC was resistant to RNase treatment.El-Hage N., Luo G.J.Gen.Virol.Replication of hepatitis C virus RNA occurs in a membrane-bound replication complex containing nonstructural viral proteins and RNA.200327612769Endoplasmic reticulum is the site of RNA replication.Pietschmann T., Lohmann V., Rutter G., Kurpanek K., Bartenschlager R.J.VirologyCharacterization of cell lines carrying self-replicating hepatitis C virus RNAs.200112521264
04.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
19.10.2004;Khlebodarova T.M.;edited
 1190.379151 461.680604 regulatory eventincreasedirectexperimentalNonstructural protein NS5BHepatitis C virushuman hepatitis C virusLee H., Shin H., Wimmer E., Paul A.V.J.Virologycis-Acting RNA Signals in the NS5B C-Terminal Coding Sequence of the Hepatitis C Virus Genome.20041086510877Wang Q.M., Hockman M.A., Staschke K., Johnson R.B., Case K.A., Lu J., Parsons S., Zhang F., Rathnachalam R., Kirkegaard K., Colacino J.M.J.VirologyOligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.200238653872Dimitrova M., Imbert I., Kieny M.P., Schuster C.J.VirologyProtein-protein interactions between hepatitis C virus nonstructural proteins.200354015414All six HCV NS proteins interact among themselves and provide additional evidence that assembly of a highly ordered multisubunit protein complex(es) probably involved in the replication of viral genome.Dimitrova M., Imbert I., Kieny M.P., Schuster C.J.VirologyProtein-protein interactions between hepatitis C virus nonstructural proteins.200354015414
05.10.2004;Khlebodarova T.M.;edited
19.10.2004;Khlebodarova T.M.;edited
 1469.738037 1333.232361 regulatory eventincreasedirectexperimentalNonstructural protein NS5BHepatitis C virushuman hepatitis C virusBartenschlager R., Lohmann V.J.General Virol.Replication of hepatitis C virus.200016311648
11.10.2004;Khlebodarova T.M.;edited
19.10.2004;Khlebodarova T.M.;edited
11.10.2004;Khlebodarova T.M.;created
 1552.367737 746.020386 eIF3Eukaryotic translation initiation factor 3Homo sapienshumanactivephosphorylatedmultimerSizova D.V., Kolupaeva V.G., Pestova T.V., Shatsky I.N., Hellen C.U.J.VirologySpecific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.199847754782The interaction of eIF3 with HCV IRES involves the p170, p116, p66 and p47 subunits.Sizova D.V., Kolupaeva V.G., Pestova T.V., Shatsky I.N., Hellen C.U.J.VirologySpecific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.199847754782 1703.860597 500.808533 NS3/NS4ANS3/NS4A complexHepatitis C virushuman hepatitis C virusactiveheterodimerYan Y., Li Y., Munshi S., Sardana V., Cole J.L., Sardana M., Steinkuehler C., Tomei L., De Francesco R., Kuo L.C., Chen Z.Protein Sci.Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form.1998837847Pang P.S., Jankowsky E., Planet P. J., Pyle A.M. EMBO J.The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding.200211681176Kyono K., Miyashiro M., Taguchi I.J.Biochem.Expression and purification of a hepatitis C virus NS3/4A complex, and characterization of its helicase activity with the Scintillation Proximity Assay system.2004245252McCoy M.A., Senior M.M., Gesell J.J., Ramanathan L., Wyss D.F.J.Molec.Biol.Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex.200110991110Failla C., Tomei L., De Francesco R.J.VirologyBoth NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.199437533760
14.10.2004;Khlebodarova T.M.;edited
15.10.2004;Khlebodarova T.M.;edited
05.10.2004;Khlebodarova T.M.;created
06.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
 1657.231200 991.422792 FpF proteinARFPalternative reading frame proteinframeshift proteinHepatitis C virushuman hepatitis C virusinactivemonomerWalewski J.L., Keller T.R., Stump D.D., Branch A.D.RNAEvidence for a new hepatitis C virus antigen encoded in an overlapping reading frame.2001710721Walewski J.L., Gutierrez J.A., Branch-Elliman W., Stump D.D., Keller T.R., Rodriguez A., Benson G., Branch A.D.RNAMutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions.2002557571Varaklioti A., Vassilaki N., Georgopoulou U., Mavromara P.J.Biol.Chem.Alternate translation occurs within the core coding region of the hepatitis C viral genome.20021771317721F protein is very unstable and its production can be stabilized by the proteasome inhibitor MG 132
05.10.2004;Khlebodarova T.M.;edited
06.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
 1867.195069 1315.564394 regulatory eventdecreaseindirectexperimentalalpha -subunit of eukaryotic initiation factor 2Homo sapienshumanHiasa Y., Kamegaya Y., Nuriya H., Onji M., Kohara M., Schmidt E.V., Chung R.T.Am.J.Gastroenterol.Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.200325282534
20.10.2004;Khlebodarova T.M.;created
20.10.2004;Khlebodarova T.M.;edited
 1659.621583 429.259796 regulatory eventincreasedirectexperimentalHepatitis C virushuman hepatitis C virusVyas J., Elia A., Clemens M.J.RNAInhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNA.2003858870Taylor D.R., Lee S.B., Romano P.R., Marshak D.R., Hinnebusch A.G., Esteban M., Mathews M.B.Mol.Cell.Biol.Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.199662956302
14.10.2004;Khlebodarova T.M.;edited
 1484.735108 279.433655 Fe(3)Fe(3) cationPonka P.Am.J.Med.Sci.Cell biology of heme.1999241256Ponka P.BloodTissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.1997125
23.6.1999.;Podkolodnaya O.A.;created
14.12.2002;Podkolodnaya O.A.;updated
 1754.802002 633.778564 regulatory eventincreaseindirectexperimentalFe(3) cationTheurl I., Zoller H., Obrist P., Datz C., Bachmann F., Elliott R.M., Weiss G.J.Infect.Dis.Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3.2004819825
20.10.2004;Khlebodarova T.M.;edited
 1686.677002 580.591064 regulatory eventdecreasedirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusMamiya N., Worman H.J.J.Biol.Chem.Hepatitis C virus core protein binds to a DEAD box RNA helicase.19991575115756
20.10.2004;Khlebodarova T.M.;edited
 1253.015748 1857.372314 regulatory eventincreaseindirectexperimentalDEAD-box protein 3Homo sapienshumanMamiya N., Worman H.J.J.Biol.Chem.Hepatitis C virus core protein binds to a DEAD box RNA helicase.19991575115756HCV core protein binds to a DEAD box RNA helicase and inhibited the translation of capped but not uncapped RNA.Mamiya N., Worman H.J.J.Biol.Chem.Hepatitis C virus core protein binds to a DEAD box RNA helicase.19991575115756
20.10.2004;Khlebodarova T.M.;edited
 1144.929810 1923.427002 regulatory eventincreasedirectexperimental90-kDa heat shock proteinHomo sapienshumanWaxman L., Whitney M., Pollok B.A., Kuo L.C., Darke P.L.Proc.Natl.Acad.Sci.USAHost cell factor requirement for hepatitis C virus enzyme maturation.20011393113935HSP90 is identified as a participant in NS2-3 cleavage. The physical association of NS2-3 with HSP90 is demonstrated by immunoprecipitation.Waxman L., Whitney M., Pollok B.A., Kuo L.C., Darke P.L.Proc.Natl.Acad.Sci.USAHost cell factor requirement for hepatitis C virus enzyme maturation.20011393113935
21.10.2004;Khlebodarova T.M.;edited
 2103.314942 1015.447143 Raf-1 kinaseRaf-1 Ser/Thr kinase (proto-oncogene)MEKKMAPKKKc-RafHomo sapienshumaninactivenon phosphorylatedhomodimerp53RasHepG2HepG2 hepatoma cell lineHomo sapienshumanMCF-7MCF-7 breast cancer cellsHomo sapienshumanEl-Ashry D., Miller D.L., Kharbanda S., Lippman M.E., Kern F.G.OncogeneConstitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis.1997423435Force T., Bonventre J.V., Heidecker G., Rapp U., Avruch J., Kyriakis J.M.Proc.Natl.Acad.Sci.USAEnzymatic characteristics of the c-Raf-1 protein kinase.199412704Yu R., Lei W., Mandlekar S., Weber M.J., Der C.J., Wu J., Kong A.-N.T.J.Biol.Chem.Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.19992754527552
21.01.2003.;Alena N.;created
 1459.171875 991.918884 Raf-1 kinaseRaf-1 Ser/Thr kinase (proto-oncogene)MEKKMAPKKKc-RafHomo sapienshumanactivephosphorylatedhomodimerp53RasHepG2HepG2 hepatoma cell lineHomo sapienshumanMCF-7MCF-7 breast cancer cellsHomo sapienshumanEl-Ashry D., Miller D.L., Kharbanda S., Lippman M.E., Kern F.G.OncogeneConstitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis.1997423435Force T., Bonventre J.V., Heidecker G., Rapp U., Avruch J., Kyriakis J.M.Proc.Natl.Acad.Sci.USAEnzymatic characteristics of the c-Raf-1 protein kinase.199412704Yu R., Lei W., Mandlekar S., Weber M.J., Der C.J., Wu J., Kong A.-N.T.J.Biol.Chem.Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.19992754527552
28.7.2000.;Grigoriev S.A.;created
09.1.2001.;Grigoriev S.A.;updated
14-Jan-02.;Alena N.;updated
19.11.2002;Nedosekina E.A.;updated
 1390.734375 872.543884 reactiondirectexperimentalRaf-1 Ser/Thr kinase (proto-oncogene)Homo sapienshumanRaf-1 Ser/Thr kinase (proto-oncogene)Homo sapienshumanKyriakis J.M. and Avruch J.Physiol.Rev.Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.2001807869
12-Feb-03.;Guryeva Y.;created
21.10.2004;Khlebodarova T.M.;edited
 1383.234375 979.418884 pRBretinoblastoma gene mRNAHomo sapienshumanmRNApRBretinoblastoma susceptibility gene 1Homo sapienshumanSaos-2Saos-2 osteosarcoma cell lineHomo sapienshumanShan B., Chang C.Y., Jones D., Lee W.H.Mol.Cell.Biol.The transcription factor E2F-1 mediates the autoregulation of RB gene expression.1994299309 The expression of RB gene is increased graduallly during the G1 transition and peaks at the G1/S boundary, reduce in S and low in G2.
02.2.2000.;Suslov V.V.;created
07.7.2000.;Suslov V.V.;updated
05.12.2001;Turn;updated
 985.640625 1130.747009 regulatory eventdecreaseindirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusCho J., Baek W., Yang S., Chang J., Sung Y.C., Suh M.Biochim.Biophys.ActaHCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation.20015966
21.10.2004;Khlebodarova T.M.;edited
 1133.546875 1188.168884 grp7878 kDa glucose-regulated protein Homo sapienshumanmRNAgrp7878-kD glucose-regulated proteinHomo sapienshumanLiberman E., Fong Y.L., Selby M.J., Choo Q.L., Cousens L., Houghton M., Yen T.S.J.VirologyActivation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.199937183722 1173.839843 933.442322 regulatory eventincreaseindirectexperimentalEnvelope glycoprotein E2 Hepatitis C virushuman hepatitis C virusLiberman E., Fong Y.L., Selby M.J., Choo Q.L., Cousens L., Houghton M., Yen T.S.J.VirologyActivation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.199937183722
21.10.2004;Khlebodarova T.M.;edited
 1997.674806 1233.237731 grp9494 kDa glucose-regulated protein)Homo sapienshumanmRNAgrp9494 kDa glucose-regulated proteinTumor rejection antigen 1Endoplasmin TRA1Homo sapienshumanLiberman E., Fong Y.L., Selby M.J., Choo Q.L., Cousens L., Houghton M., Yen T.S.J.VirologyActivation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.199937183722 1140.252930 1026.694763 irreversible reactionindirectexperimental94 kDa glucose-regulated proteinHomo sapienshumanHomo sapienshumanLiberman E., Fong Y.L., Selby M.J., Choo Q.L., Cousens L., Houghton M., Yen T.S.J.VirologyActivation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.199937183722
21.10.2004;Khlebodarova T.M.;edited
 1055.916993 962.183044 regulatory eventincreaseindirectexperimentalEnvelope glycoprotein E2 Hepatitis C virushuman hepatitis C virusLiberman E., Fong Y.L., Selby M.J., Choo Q.L., Cousens L., Houghton M., Yen T.S.J.VirologyActivation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.199937183722
21.10.2004;Khlebodarova T.M.;edited
 1993.221681 1246.597106 Characterization of cell lines carrying self-replicating hepatitis C virus RNAs. Pietschmann T., Lohmann V., Rutter G., Kurpanek K., Bartenschlager R. J.Virology 2001 1252 1264
18.10.2004;Khlebodarova T.M.;created
 16 h half-life of basal phosphorylated form of NS5A was 16 h, and hilf-life of hyperphophorylated form of NS5A was 7 h. NS5ANon-structural 5A protein Hepatitis C virushuman hepatitis C virusactivephosphorylatedmonomerShi S.T., Polyak S.J., Tu H., Taylor D.R., Gretch D.R., Lai M.M.VirologyHepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins.2002198210Coito C., Diamond D.L., Neddermann P., Korth M.J., Katze M.G.J.VirologyHigh-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein200435023513
22.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
 1768.687989 458.952485 regulatory eventincreaseindirectexperimentalC-terminal polypeptideHepatitis C virushuman hepatitis C virusTardif K.D., Mori K., Kaufman R.J., Siddiqui A.J.Biol.Chem.Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.20041715817164Tardif K.D., Mori K., Siddiqui A.J.VirologyHepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway.200274537459
25.10.2004;Khlebodarova T.M.;edited
 1949.787842 1518.928893 irreversible reactiondirectexperimentalCyclic-AMP-dependent transcription factor ATF-6 betaHomo sapienshumanCyclic-AMP-dependent transcription factor ATF-6 betaHomo sapienshumanHaze K., Yoshida H., Yanagi H., Yura T., Mori K.Mol.Biol.CellMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.199937873799
25.10.2004;Khlebodarova T.M.;edited
 1250.205078 2009.219727 regulatory eventincreaseindirectexperimentalTardif K.D., Mori K., Siddiqui A.J.VirologyHepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway.200274537459Haze K., Yoshida H., Yanagi H., Yura T., Mori K.Mol.Biol.CellMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.199937873799
25.10.2004;Khlebodarova T.M.;edited
 1380.794922 1980.747070 YWHAE14-3-3 protein epsilon 14-3-3EHomo sapienshumanSWISS-PROTP62258143E_HUMANactivehomodimerAoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.J.VirologyHepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.200017361741
21.10.2004;Khlebodarova T.M.;edited
 1283.562500 966.682311 HSP9090-kDa heat shock proteinHomo sapienshumanSWISS-PROTP08238HS9B_HUMANHSP90beta90-kDa heat shock proteinHomo sapienshumanactivephosphorylatedmonomerWaxman L., Whitney M., Pollok B.A., Kuo L.C., Darke P.L.Proc.Natl.Acad.Sci.USAHost cell factor requirement for hepatitis C virus enzyme maturation.20011393113935
08.6.2000.;Stepanenko I.L.;created
26.10.2004;Khlebodarova T.M.;edited
 2107.314942 1076.447143 p21 Waf1p21 Waf1 kinase inhibitorCip1(Cdk-interacting protein 1)SDI-1WAF1Homo sapienshumanSWISS-PROTP38936CDNA_HUMANCDKN1ACip1SDI1WAF1CAP20CDKN1p21 Waf1p21 Waf1 kinase inhibitorHomo sapienshumanactiveno datano datap53cell cycleDatto M.B., Yu Y., Wang X.F.J.Biol.Chem.Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter.1995a2862328628Oka K., Nagano-Fujii M., Yoshida I., Hidajat R., Deng L., Akutsu M., Hotta H.Microbiol.Immunol. Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins.2003429438 The cyclin-dependent kinase inhibitor p21waf1/Cip1 is a downstream effector of the p53-dependent cell growth arrest.
25.05.2001;Grigoriev S.A.;updated
29.06.2002;Turn;updated
26.12.2000;Grigoriev S.A.;created
06.10.2004;Khlebodarova T.M.;edited
26.10.2004;Khlebodarova T.M.;edited
 523.471290 1261.502174 no data reactiondirectexperimentalEnvelope glycoprotein E2 Hepatitis C virushuman hepatitis C virusEnvelope glycoprotein E1 Hepatitis C virushuman hepatitis C virusEnvelope glycoprotein E1/E2Hepatitis C virushuman hepatitis C virusDeleersnyder V., Pillez A., Wychowski C., Blight K., Xu J., Hahn Y.S., Rice C.M., Dubuisson J.J.VirologyFormation of native hepatitis C virus glycoprotein complexes.1997697704Drummer H.E., Poumbourios P.J.Biol.Chem.Hepatitis C virus glycoprotein E2 contains a membrane-proximal heptad repeat sequence that is essential for E1E2 glycoprotein heterodimerization and viral entry.20043006630072
05.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
 2333.935395 1373.464783 28S rRNA28S ribosomal RNAHomo sapienshumanrRNA28S rRNA28S ribosomal RNAHomo sapienshumanIwawaki T., Hosoda A., Okuda T., Kamigori Y., Nomura-Furuwatari C., Kimata Y., Tsuru A., Kohno K.Nat.Cell.Biol.Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.2001158164 790.750977 1788.240967 regulatory eventincreaseindirectexperimentalHomo sapienshumanIwawaki T., Hosoda A., Okuda T., Kamigori Y., Nomura-Furuwatari C., Kimata Y., Tsuru A., Kohno K.Nat.Cell.Biol.Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.2001158164
28.10.2004;Khlebodarova T.M.;edited
 826.688477 1743.944092 regulatory eventdecreaseindirectexperimentalSerine/threonine protein kinase/endoribonuclease IRE2Homo sapienshumanIwawaki T., Hosoda A., Okuda T., Kamigori Y., Nomura-Furuwatari C., Kimata Y., Tsuru A., Kohno K.Nat.Cell.Biol.Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.2001158164
28.10.2004;Khlebodarova T.M.;edited
 1130.594727 1993.319092 regulatory eventincreaseindirectexperimentalIwawaki T., Hosoda A., Okuda T., Kamigori Y., Nomura-Furuwatari C., Kimata Y., Tsuru A., Kohno K.Nat.Cell.Biol.Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.2001158164
28.10.2004;Khlebodarova T.M.;edited
 1378.641602 2114.412842 accumulation of lipid droplets lipid accumulationlipid accumulation
28.10.2004;Khlebodarova T.M.;created
28.10.2004;Khlebodarova T.M.;edited
 2374.266602 567.872650 APOA2apolipoprotein AIIAPOAIIHomo sapienshumanSWISS-PROTP02652APA2_HUMANapolipoprotein AIIAPOA2Homo sapienshumanactiveno datahomodimerintestineintestineHomo sapienshumanliverliverHomo sapienshumanBreslow J.L.Physiol.Rev.Apolipoprotein genetic variation and human disease.198885132 In vitro apo A-II has been shown to displace apo A-I from HDL particles as well as to both activate hepatic lipase and inhibit LCAT [Breslow J.L., 1988]
30-Nov-02.;Proscura A.L.;created
07-Dec-02.;Proscura A.L.;updated
28.10.2004;Khlebodarova T.M.;edited
 2183.641602 598.263306 regulatory eventincreaseindirectexperimentalapolipoprotein AIIHomo sapienshumanSabile A., Perlemuter G., Bono F., Kohara K., Demaugre F., Kohara M., Matsuura Y., Miyamura T., Brechot C., Barba G.HepatologyHepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates.199910641076
28.10.2004;Khlebodarova T.M.;edited
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28.10.2004;Khlebodarova T.M.;edited
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20.10.2004;Khlebodarova T.M.;edited
 1136.687257 1165.608581 E2Envelope glycoprotein E2 NS1GP68GP70Hepatitis C virushuman hepatitis C virusactivemonomerLin C., Lindenbach B.D., Pragai B.M., McCourt D.W., Rice C.M.J.VirologyProcessing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini.199450635073Penin F., Combet C., Germanidis G., Frainais P.O., Deleage G., Pawlotsky J.M.J.VirologyConservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment.200157035710Deleersnyder V., Pillez A., Wychowski C., Blight K., Xu J., Hahn Y.S., Rice C.M., Dubuisson J.J.VirologyFormation of native hepatitis C virus glycoprotein complexes.1997697704Keck Z.Y., Op De Beeck A., Hadlock K.G., Xia J., Li T.K., Dubuisson J., Foung S.K.J.VirologyHepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions.200492249232
14.10.2004;Khlebodarova T.M.;edited
22.10.2004;Khlebodarova T.M.;edited
09.11.2004;Khlebodarova T.M.;edited
05.10.2004;Khlebodarova T.M.;edited
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07.10.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
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01.10.2004;Khlebodarova T.M.;edited
07.10.2004;Khlebodarova T.M.;edited
01.11.2004;Khlebodarova T.M.;edited
01.10.2004;Khlebodarova T.M.;created
11.11.2004;Khlebodarova T.M.;edited
04.10.2004;Khlebodarova T.M.;edited
 1536.472901 446.047792 Cpcore proteinHepatitis C virushuman hepatitis C virusSWISS-PROTQ01404POLG_HCVH4SWISS-PROTP27959POLG_HCVJ2TrEMBLP87760P87760TrEMBLQ8BER8Q8BER8TrEMBLQ8BES0Q8BES0activemultimerOkamoto H., Kurai K., Okada S., Yamamoto K., Lizuka H., Tanaka T., Fukuda S., Tsuda F., Mishiro S.VirologyFull-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes.1992331341Abe K., Inchauspe G., Fujisawa K.J.Gen.Virol.Genomic characterization and mutation rate of hepatitis C virus isolated from a patient who contracted hepatitis during an epidemic of non-A, non-B hepatitis in Japan.199227252729Dansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730Santolini E., Migliaccio G., La Monica N.J.VirologyBiosynthesis and biochemical properties of the hepatitis C virus core protein.199436313641Ray R.B., Ray R.FEMS Microbiol.Lett.Hepatitis C virus core protein: intriguing properties and functional relevance.2001149156Barba G., Harper F., Harada T., Kohara M., Goulinet S., Matsuura Y., Eder G., Schaff Z., Chapman M.J., Miyamura T., Brechot C.Proc.Natl.Acad.Sci.USAHepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets.199712001205Walewski J.L., Gutierrez J.A., Branch-Elliman W., Stump D.D., Keller T.R., Rodriguez A., Benson G., Branch A.D.RNAMutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions.2002557571Chang S.C., Yen J.H., Kang H.Y., Jang M.H., Chang M.F.Biochem.Biophys.Res.Commun.Nuclear localization signals in the core protein of hepatitis C virus.199412841290Kunkel M., Watowich S.J.FEBS Lett.Biophysical characterization of hepatitis C virus core protein: implications for interactions within the virus and host.2004174180
06.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
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19.10.2004;Khlebodarova T.M.;edited
09.11.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
 2118.702882 1674.211182 HCVppHepatitis C polyproteinHepatitis C virushuman hepatitis C virusTrEMBLQ6DQ94Q6DQ94TrEMBLQ6GYR8Q6GYR8SWISS-PROTP26664POLG_HCV1SWISS-PROTPOLG_HCVJ8P26661SWISS-PROTP26662POLG_HCVJASWISS-PROTP26660POLG_HCVJ6SWISS-PROTP27958POLG_HCVHinactivemonomerLocarnini S.A., Bartholomeusz A.J.Gastroenterol.Hepatol.Advances in hepatitis C: what is coming in the next 5 years?2002442447Kato N., Hijikata M., Ootsuyama Y., Nakagawa M., Ohkoshi S., Sugimura T., Shimotohno K.Proc.Natl.Acad.Sci.USAMolecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.199095249528Inchauspe G., Zebedee S., Lee D.H., Sugitani M., Nasoff M., Prince A.M.Proc.Natl.Acad.Sci.USAGenomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates.19911029210296Okamoto H., Okada S., Sugiyama Y., Kurai K., Iizuka H., Machida A., Miyakawa Y., Mayumi M.J.Gen.Virol.Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions.199126972704Kalinina O., Norder H., Magnius L.O.J.Gen.Virol.Full-length open reading frame of a recombinant hepatitis C virus strain from St Petersburg: proposed mechanism for its formation200418531857Grakoui A., Wychowski C., Lin C., Feinstone S.M., Rice C.M.J.VirologyExpression and identification of hepatitis C virus polyprotein cleavage products.199313851395Choo Q.L., Richman K.H., Han J.H., Berger K., Lee C., Dong C., Gallegos C., Coit D., Medina-Selby R., Barr P.J., et al.Proc.Natl.Acad.Sci.USAGenetic organization and diversity of the hepatitis C virus.199124512455Abe K., Inchauspe G., Fujisawa K.J.Gen.Virol.Genomic characterization and mutation rate of hepatitis C virus isolated from a patient who contracted hepatitis during an epidemic of non-A, non-B hepatitis in Japan.199227252729Tellinghuisen T.L., Rice C.M.Curr.Opin.Microbiol.Interaction between hepatitis C virus proteins and host cell factors.2002419427
01.10.2004;Khlebodarova T.M.;edited
07.10.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
06.10.2004;Khlebodarova T.M.;edited
 1894.452697 866.276643 + HCV_rHepatitis C virus repliconhuman hepatitis virus C HCV repliconhuman hepatitis C virus repliconHepatitis C virushuman hepatitis C virusmRNAGenBankNC_004102NC_004102EMBLAJ000009HCVPOLYPEMBLD89815D89815EMBLD28917HPCK3AEMBLD17763HPCEGSEMBLD30613HPCPPEMBLD10934HPCRNAEMBLM67463HPCRNAEMBLD13558HPCJ483HCVHepatitis C virusHepatitis C virushuman hepatitis C virusLyons A.J., Robertson H.D.J.Biol.Chem.Detection of tRNA-like structure through RNase P cleavage of viral internal ribosome entry site RNAs near the AUG start triplet.20032684426850Dumas E., Staedel C., Colombat M., Reigadas S., Chabas S., Astier-Gin T., Cahour A., Litvak S., Ventura M.Nucl.Acids Res.A promoter activity is present in the DNA sequence corresponding to the hepatitis C virus 5' UTR.200312751281Lohmann V., Korner F., Koch J., Herian U., Theilmann L., Bartenschlager R.ScienceReplication of subgenomic hepatitis C virus RNAs in a hepatoma cell line.1999110113single-stranded, positive-sense RNA
30.09.2004;Ananko E.A.;edited
30.09.2004;Ananko E.A.;created
04.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
05.12.2004;Ananko E.A.;edited
12.04.2006;Mishchenko E.L.;edited
11.11.2004;Khlebodarova T.M.;edited
 1255.114013 238.422776 AssemblyAssembly of HCV
11.10.2004;Khlebodarova T.M.;created
11.10.2004;Khlebodarova T.M.;edited
 2062.624268 1816.925659 no data reactiondirectexperimentalHepatitis C virushuman hepatitis C viruscore proteinHepatitis C virushuman hepatitis C virusKunkel M., Lorinczi M., Rijnbrand R., Lemon S.M., Watowich S.J.J.VirologySelf-assembly of nucleocapsid-like particles from recombinant hepatitis C virus core protein.200121192129Tanaka Y., Shimoike T., Ishii K., Suzuki R., Suzuki T., Ushijima H., Matsuura Y., Miyamura T.VirologySelective binding of hepatitis C virus core protein to synthetic oligonucleotides corresponding to the 5' untranslated region of the viral genome.2000229236Majeau N., Gagne V., Boivin A., Bolduc M., Majeau J.A., Ouellet D., Leclerc D.J.Gen.Virol.The N-terminal half of the core protein of hepatitis C virus is sufficient for nucleocapsid formation.2004971981
15.11.2004;Khlebodarova T.M.;created
15.11.2004;Khlebodarova T.M.;edited
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15.11.2004;Khlebodarova T.M.;edited
15.11.2004;Khlebodarova T.M.;created
 2120.849365 1869.425659 irreversible reactiondirectexperimentalEnvelope glycoprotein E1/E2Hepatitis C virushuman hepatitis C virusZhao W., Liao G.Y., Jiang Y.J., Jiang S.D.Chin.Med.J.Expression and self-assembly of HCV structural proteins into virus-like particles and their immunogenicity.200412171222Bartosch B., Dubuisson J., Cosset F.L.J.Exp.Med.Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes.2003633642
15.11.2004;Khlebodarova T.M.;created
15.11.2004;Khlebodarova T.M.;edited
 1905.849365 1855.925659 Release of HCVRelease of HCV
15.11.2004;Khlebodarova T.M.;created
 2714.324219 2101.925659 irreversible reactiondirectexperimentalEnvelope glycoprotein E1/E2Hepatitis C virushuman hepatitis C viruscore proteinHepatitis C virushuman hepatitis C virusHepatitis C virushuman hepatitis C virusSakai A., Claire M.S., Faulk K., Govindarajan S., Emerson S.U., Purcell R.H., Bukh J.Proc.Natl.Acad.Sci.USAThe p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences.20031164611651
15.11.2004;Khlebodarova T.M.;edited
15.11.2004;Khlebodarova T.M.;created
 2319.324219 1961.925659 regulatory eventincreasedirectexperimentalp7 proteinHepatitis C virushuman hepatitis C virusSakai A., Claire M.S., Faulk K., Govindarajan S., Emerson S.U., Purcell R.H., Bukh J.Proc.Natl.Acad.Sci.USAThe p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences.20031164611651
15.11.2004;Khlebodarova T.M.;created
15.11.2004;Khlebodarova T.M.;edited
 2254.324219 1982.925659 regulatory eventincreasedirectexperimentalp7 proteinHepatitis C virushuman hepatitis C virusSakai A., Claire M.S., Faulk K., Govindarajan S., Emerson S.U., Purcell R.H., Bukh J.Proc.Natl.Acad.Sci.USAThe p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences.20031164611651
15.11.2004;Khlebodarova T.M.;edited
15.11.2004;Khlebodarova T.M.;created
 2394.324219 1951.925659 CpCore proteinHepatitis C virushuman hepatitis C virusactivephosphorylatedmultimerAoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.J.VirologyHepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.200017361741
17.11.2004;Khlebodarova T.M.;created
 1413.592163 1068.157837 irreversible reactiondirectexperimentalcore proteinHepatitis C virushuman hepatitis C virusCore proteinHepatitis C virushuman hepatitis C virusAoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.J.VirologyHepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.200017361741
17.11.2004;Khlebodarova T.M.;edited
17.11.2004;Khlebodarova T.M.;created
 1348.592163 1131.907837 regulatory eventondirectexperimentalprotein kinase AHomo sapienshumanAoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.J.VirologyHepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.200017361741
17.11.2004;Khlebodarova T.M.;created
17.11.2004;Khlebodarova T.M.;edited
 1323.592163 1079.407837 regulatory eventondirectexperimentalprotein kinase CHomo sapienshumanAoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.J.VirologyHepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.200017361741
17.11.2004;Khlebodarova T.M.;edited
17.11.2004;Khlebodarova T.M.;created
 1316.092163 1099.720337 regulatory eventincreasedirectexperimentalCore proteinHepatitis C virushuman hepatitis C virusAoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.J.VirologyHepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.200017361741
17.11.2004;Khlebodarova T.M.;created
17.11.2004;Khlebodarova T.M.;edited
 1391.092163 1029.407837 regulatory eventondirectexperimental14-3-3 protein epsilon Homo sapienshumanAoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.J.VirologyHepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.200017361741
17.11.2004;Khlebodarova T.M.;edited
17.11.2004;Khlebodarova T.M.;created
 1337.342163 1004.407837 PKCprotein kinase CHomo sapienshumanactivephosphorylatedno dataAoki H., Hayashi J., Moriyama M., Arakawa Y., Hino O.J.VirologyHepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.200017361741
13.11.2001;Makhneva T.V.;created
17.11.2004;Khlebodarova T.M.;edited
 1203.592163 1100.345337 regulatory eventondirectexperimentaldsRNA-dependent cAMP-independent protein serine/threonine kinaseHomo sapienshumanHiasa Y., Kamegaya Y., Nuriya H., Onji M., Kohara M., Schmidt E.V., Chung R.T.Am.J.Gastroenterol.Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.200325282534
20.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;created
17.11.2004;Khlebodarova T.M.;edited
 2005.196778 331.109802 p68Probable RNA-dependent helicase p68 DEAD-box protein p68DEAD-box protein 5DDX5HELR HLR1Homo sapienshumanSWISS-PROTP17844DDX5_HUMANactivemonomerGoh K.C., Haque S.J., Williams B.R.EMBO J.p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons.199956015608
17.11.2004;Khlebodarova T.M.;created
 1108.592163 556.547729 regulatory eventincreasedirectexperimentalProbable RNA-dependent helicase p68 Homo sapienshumanGoh P.Y., Tan Y.J., Lim S.P., Tan Y.H., Lim S.G., Fuller-Pace F., Hong W.J.VirologyCellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication.200452885298
17.11.2004;Khlebodarova T.M.;edited
 1151.092163 511.547729 no data reactiondirectexperimentalProbable RNA-dependent helicase p68 Homo sapienshumanProbable RNA-dependent helicase p68 Homo sapienshumanGoh P.Y., Tan Y.J., Lim S.P., Tan Y.H., Lim S.G., Fuller-Pace F., Hong W.J.VirologyCellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication.200452885298
17.11.2004;Khlebodarova T.M.;edited
 1152.342163 717.797729 regulatory eventondirectexperimentalNonstructural protein NS5BHepatitis C virushuman hepatitis C virusGoh P.Y., Tan Y.J., Lim S.P., Tan Y.H., Lim S.G., Fuller-Pace F., Hong W.J.VirologyCellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication.200452885298
17.11.2004;Khlebodarova T.M.;edited
 1403.435913 1370.735229 HCV virionMoriishi K., Matsuura Y.Antivir.Chem.Chemother.Mechanisms of hepatitis C virus infection.2003285297Polyak S.J.Clin.Liver Dis.Hepatitis C virus--cell interactions and their role in pathogenesis.20036788
17.11.2004;Khlebodarova T.M.;edited
11.10.2004;Khlebodarova T.M.;edited
23.11.2004;Khlebodarova T.M.;edited
 311.715546 181.964294 2196.900057 1696.409385 black white rounded_rect E1/E2Envelope glycoprotein E1/E2Hepatitis C virushuman hepatitis C virusactiveglycosylatedheterodimerPenin F., Combet C., Germanidis G., Frainais P.O., Deleage G., Pawlotsky J.M.J.VirologyConservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment.200157035710Deleersnyder V., Pillez A., Wychowski C., Blight K., Xu J., Hahn Y.S., Rice C.M., Dubuisson J.J.VirologyFormation of native hepatitis C virus glycoprotein complexes.1997697704Kurihara C., Tsuzuki Y., Hokari R., Nakashima H., Mataki N., Kuroki M., Kawaguchi A., Nagao S., Kondo T., Miura S. J.Med.Virol.A highly hydrophobic domain within hypervariable region 1 may be related to the entry of hepatitis C virus into cultured human hepatoma cells.2004546555Goffard A., Dubuisson J.BiochimieGlycosylation of hepatitis C virus envelope proteins.2003295301Kaimori A., Kanto T., Kwang Limn C., Komoda Y., Oki C., Inoue M., Miyatake H., Itose I., Sakakibara M., Yakushijin T., Takehara T., Matsuura Y., Hayashi N.VirologyPseudotype hepatitis C virus enters immature myeloid dendritic cells through the interaction with lectin.20047483Op De Beeck A., Voisset C., Bartosch B., Ciczora Y., Cocquerel L., Keck Z., Foung S., Cosset F.L., Dubuisson J.J.VirologyCharacterization of functional hepatitis C virus envelope glycoproteins.200429943002
12.10.2004;Khlebodarova T.M.;edited
26.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
01.11.2004;Khlebodarova T.M.;edited
09.11.2004;Khlebodarova T.M.;edited
22.10.2004;Khlebodarova T.M.;edited
10.11.2004;Khlebodarova T.M.;edited
 2193.986389 1694.893800 HCV nucleocapsid
15.10.2004;Khlebodarova T.M.;created
 210.857773 113.982147 2256.703943 1730.650459 black pink rounded_rect 50 Cpcore proteinHepatitis C virushuman hepatitis C virusSWISS-PROTQ01404POLG_HCVH4SWISS-PROTP27959POLG_HCVJ2TrEMBLP87760P87760TrEMBLQ8BER8Q8BER8TrEMBLQ8BES0Q8BES0activemultimerOkamoto H., Kurai K., Okada S., Yamamoto K., Lizuka H., Tanaka T., Fukuda S., Tsuda F., Mishiro S.VirologyFull-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes.1992331341Abe K., Inchauspe G., Fujisawa K.J.Gen.Virol.Genomic characterization and mutation rate of hepatitis C virus isolated from a patient who contracted hepatitis during an epidemic of non-A, non-B hepatitis in Japan.199227252729Dansako H., Naganuma A., Nakamura T., Ikeda F., Nozaki A., Kato N.Virus Res.Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.20031730Santolini E., Migliaccio G., La Monica N.J.VirologyBiosynthesis and biochemical properties of the hepatitis C virus core protein.199436313641Ray R.B., Ray R.FEMS Microbiol.Lett.Hepatitis C virus core protein: intriguing properties and functional relevance.2001149156Barba G., Harper F., Harada T., Kohara M., Goulinet S., Matsuura Y., Eder G., Schaff Z., Chapman M.J., Miyamura T., Brechot C.Proc.Natl.Acad.Sci.USAHepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets.199712001205Walewski J.L., Gutierrez J.A., Branch-Elliman W., Stump D.D., Keller T.R., Rodriguez A., Benson G., Branch A.D.RNAMutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions.2002557571Chang S.C., Yen J.H., Kang H.Y., Jang M.H., Chang M.F.Biochem.Biophys.Res.Commun.Nuclear localization signals in the core protein of hepatitis C virus.199412841290Kunkel M., Watowich S.J.FEBS Lett.Biophysical characterization of hepatitis C virus core protein: implications for interactions within the virus and host.2004174180
06.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
 2255.670961 1727.963137 + HCV_rHepatitis C virus repliconhuman hepatitis virus C HCV repliconhuman hepatitis C virus repliconHepatitis C virushuman hepatitis C virusmRNAGenBankNC_004102NC_004102EMBLAJ000009HCVPOLYPEMBLD89815D89815EMBLD28917HPCK3AEMBLD17763HPCEGSEMBLD30613HPCPPEMBLD10934HPCRNAEMBLM67463HPCRNAEMBLD13558HPCJ483HCVHepatitis C virusHepatitis C virushuman hepatitis C virusLyons A.J., Robertson H.D.J.Biol.Chem.Detection of tRNA-like structure through RNase P cleavage of viral internal ribosome entry site RNAs near the AUG start triplet.20032684426850Dumas E., Staedel C., Colombat M., Reigadas S., Chabas S., Astier-Gin T., Cahour A., Litvak S., Ventura M.Nucl.Acids Res.A promoter activity is present in the DNA sequence corresponding to the hepatitis C virus 5' UTR.200312751281Lohmann V., Korner F., Koch J., Herian U., Theilmann L., Bartenschlager R.ScienceReplication of subgenomic hepatitis C virus RNAs in a hepatoma cell line.1999110113single-stranded, positive-sense RNA
30.09.2004;Ananko E.A.;edited
30.09.2004;Ananko E.A.;created
04.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
05.12.2004;Ananko E.A.;edited
12.04.2006;Mishchenko E.L.;edited
11.11.2004;Khlebodarova T.M.;edited
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18.10.2004;Khlebodarova T.M.;created
 14.5 h NS3Protease/helicase NS3 HepacivirinP70Hepatitis C virushuman hepatitis C virusSWISS-PROTP26660POLG_HCVJ6activemonomerLove R.A., Parge H.E., Wickersham J.A., Hostomsky Z., Habuka N., Moomaw E.W., Adachi T., Hostomska Z.CellThe crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.1996331342Yao N., Hesson T., Cable M., Hong Z., Kwong A.D., Le H.V., Weber P.C.Nat.Struct.Biol.Structure of the hepatitis C virus RNA helicase domain.1997463467Wang W., Lahser F.C., Yi .M., Wright-Minogue J., Xia E., Weber P.C., Lemon S.M., Malcolm B.A.J.VirologyConserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition.2004700709Shoji I., Suzuki T., Sato M., Aizaki H., Chiba T., Matsuura Y., Miyamura T.VirologyInternal processing of hepatitis C virus NS3 protein.1999315323Yao N., Hesson T., Cable M., Hong Z., Kwong A.D., Le H.V., Weber P.C.Nat.Struct.Biol.Structure of the hepatitis C virus RNA helicase domain.1997463467Locatelli G.A., Gosselin G., Spadari S., Maga G.J.Molec.Biol.Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.2001683694Muramatsu S., Ishido S., Fujita T., Itoh M., Hotta H.J.VirologyNuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.199749544961Kim J.L., Morgenstern K.A., Griffith J.P., Dwyer M.D., Thomson J.A., Murcko M.A., Lin C., Caron P.R.StructureHepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.199889100
05.10.2004;Khlebodarova T.M.;edited
11.10.2004;Khlebodarova T.M.;edited
15.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
11.11.2004;Khlebodarova T.M.;edited
06.10.2004;Khlebodarova T.M.;edited
25.11.2004;Khlebodarova T.M.;edited
 1647.530518 803.676699 oval black lightcyan regulatory eventincreasedirectexperimentalCD81 antigenHomo sapienshumanCocquerel L., Kuo C.C., Dubuisson J., Levy S.J.VirologyCD81-dependent binding of hepatitis C virus E1E2 heterodimers.20031067710683Roccasecca R., Ansuini H., Vitelli A., Meola A., Scarselli E., Acali S., Pezzanera M., Ercole B.B., McKeating J., Yagnik A., Lahm A., Tramontano A., Cortese R., Nicosia A.J.VirologyBinding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2.200318561867Pileri P., Uematsu Y., Campagnoli S., Galli G., Falugi F., Petracca R., Weiner A.J., Houghton M., Rosa D., Grandi G., Abrignani S.ScienceBinding of hepatitis C virus to CD81.1998938941Wunschmann S., Medh J.D., Klinzmann D., Schmidt W.N., Stapleton J.T.J.VirologyCharacterization of hepatitis C virus (HCV) and HCV E2 interactions with CD81 and the low-density lipoprotein receptor.20001005510062Zhang J., Randall G., Higginbottom A., Monk P., Rice C.M., McKeating J.A.J.VirologyCD81 is required for hepatitis C virus glycoprotein-mediated viral infection.200414481455CD81 is a coreceptor for HCV glycoprotein-dependent viral cell entry.Zhang J., Randall G., Higginbottom A., Monk P., Rice C.M., McKeating J.A.J.VirologyCD81 is required for hepatitis C virus glycoprotein-mediated viral infection.200414481455
12.10.2004;Khlebodarova T.M.;edited
14.10.2004;Khlebodarova T.M.;edited
 682.411071 313.388672 regulatory eventincreasedirectexperimentalLDL receptorHomo sapienshumanAgnello V., Abel G., Elfahal M., Knight G.B., Zhang Q.X.Proc.Natl.Acad.Sci.USAHepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor.19991276612771Wunschmann S., Medh J.D., Klinzmann D., Schmidt W.N., Stapleton J.T.J.VirologyCharacterization of hepatitis C virus (HCV) and HCV E2 interactions with CD81 and the low-density lipoprotein receptor.20001005510062Monazahian M., Bohme I., Bonk S., Koch A., Scholz C., Grethe S., Thomssen R.J.Med.Virol.Low density lipoprotein receptor as a candidate receptor for hepatitis C virus.1999223229
12.10.2004;Khlebodarova T.M.;edited
14.10.2004;Khlebodarova T.M.;edited
 529.150818 427.214355 regulatory eventincreasedirectexperimentalScavenger receptor class B type IHomo sapienshumanBartosch B., Vitelli A., Granier C., Goujon C., Dubuisson J., Pascale S., Scarselli E., Cortese R., Nicosia A., Cosset .FL.J.Biol.Chem.Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.20034162441630
15.10.2004;Khlebodarova T.M.;edited
 640.191344 312.562073 virus ion channelCarrere-Kremer S., Montpellier-Pala C., Cocquerel L., Wychowski C., Penin F., Dubuisson J.J.VirologySubcellular localization and topology of the p7 polypeptide of hepatitis C virus.200237203730Pavlovic D., Neville D.C., Argaud O., Blumberg B., Dwek R.A., Fischer W.B., Zitzmann N.Proc.Natl.Acad.Sci.USAThe hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.200361046108Griffin S.D., Beales LP., Clarke D.S., Worsfold O., Evans S.D., Jaeger J., Harris M.P., Rowlands D.J.FEBS Lett.The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.20033438Premkumar A., Wilson L., Ewart G.D., Gage P.W.FEBS Lett.Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride.200499103
19.10.2004;Khlebodarova T.M.;created
19.10.2004;Khlebodarova T.M.;edited
20.10.2004;Khlebodarova T.M.;edited
 266.534325 99.953246 2736.654994 1455.128969 K+Potassium cation
02.3.2000.;Ignatieva E.V.;created
15.12.2002;Ignatieva E.V.;updated
 2854.552736 1498.649841 Na+Sodium cation
02.3.2000.;Ignatieva E.V.;created
06.3.2000.;Ignatieva E.V.;updated
 2903.865236 1498.649841 Ca++Calcium cation (II)
18.10.1999;Alex;created
06.3.2000.;Ignatieva E.V.;updated
 2950.445314 1499.873474 p7p7 proteinHepatitis C virushuman hepatitis C virusactivemultimerGriffin S.D., Beales LP., Clarke D.S., Worsfold O., Evans S.D., Jaeger J., Harris M.P., Rowlands D.J.FEBS Lett.The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.20033438Griffin S.D., Harvey R., Clarke D.S., Barclay W.S., Harris M., Rowlands D.J.J.Gen.Virol.A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria.2004451461
11.11.2004;Khlebodarova T.M.;edited
 2788.839111 1446.914490 black yellow rounded_rect 70 SRBIScavenger receptor class B type Ihigh density lipoprotein receptorScavenger receptor class B1SCARB1SRB1SR-BIHomo sapienshumanSWISS-PROTQ8WTV0SRC1_HUMANactiveno datano dataMacrophageMacrophagesHomo sapienshumanmonocytesmonocytic cellsHomo sapienshumanliverliverHomo sapienshumanBartosch B., Vitelli A., Granier C., Goujon C., Dubuisson J., Pascale S., Scarselli E., Cortese R., Nicosia A., Cosset .FL.J.Biol.Chem.Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.20034162441630Scarselli E., Ansuini H., Cerino R., Roccasecca R.M., Acali S., Filocamo G., Traboni C., Nicosia A., Cortese R., Vitelli A.EMBO J.The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.200250175025Hullinger T.G., Panek R.L., Xu X., Karathanasis S.K.J.Biol.Chem.p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain.20014680746814 LPS (repression, macrophages) [Hullinger T.G. et al., 2001] LPS (repression, monocytes) [Hullinger T.G. et al., 2001]
07-Dec-02.;Proscura A.L.;created
11-Dec-02.;Proscura A.L.;updated
15.10.2004;Khlebodarova T.M.;edited
18.10.2004;Khlebodarova T.M.;edited
 696.653016 240.665100 CD81CD81 antigen26 kDa cell surface protein TAPA-1Target of the antiproliferative antibody 1 TAPA1Homo sapienshumanSWISS-PROTP60033CD81_HUMANactivemonomerCocquerel L., Kuo C.C., Dubuisson J., Levy S.J.VirologyCD81-dependent binding of hepatitis C virus E1E2 heterodimers.20031067710683Roccasecca R., Ansuini H., Vitelli A., Meola A., Scarselli E., Acali S., Pezzanera M., Ercole B.B., McKeating J., Yagnik A., Lahm A., Tramontano A., Cortese R., Nicosia A.J.VirologyBinding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2.200318561867Zhang J., Randall G., Higginbottom A., Monk P., Rice C.M., McKeating J.A.J.VirologyCD81 is required for hepatitis C virus glycoprotein-mediated viral infection.200414481455
12.10.2004;Khlebodarova T.M.;edited
 751.884960 253.258361 CD209LCD209 antigen-like protein 1 Dendritic cell-specific ICAM-3-grabbing nonintegrin 2DC-SIGN2DC-SIGN related proteinDC-SIGNRLiver/lymph node-specific ICAM-3-grabbing nonintegrinL-SIGNCD209L1Homo sapienshumanSWISS-PROTQ9H2X3209L_HUMANactivemultimerPohlmann S., Zhang J., Baribaud F., Chen Z., Leslie G.J., Lin G., Granelli-Piperno A., Doms R.W., Rice C.M., McKeating J.A.J.VirologyHepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.200340704080Gardner J.P., Durso R.J., Arrigale R.R., Donovan G.P., Maddon P.J., Dragic T., Olson W.C.Proc.Natl.Acad.Sci.USAL-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus.200344984503Lozach P.Y., Amara A., Bartosch B., Virelizier J.L., Arenzana-Seisdedos F., Cosset F.L., Altmeyer R.J.Biol.Chem.C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particles.20043203532045
12.10.2004;Khlebodarova T.M.;edited
15.10.2004;Khlebodarova T.M.;edited
 380.805114 465.664551 LDLRLDL receptorHomo sapienshumanSWISS-PROTP01130LDLR_HUMANLDLRLDL receptor geneHomo sapienshumanactiveno datano dataOMEomental microvascular endothelial cellsHomo sapienshumanPBMCperipheral blood mononuclear cellsHomo sapienshumanWunschmann S., Medh J.D., Klinzmann D., Schmidt W.N., Stapleton J.T.J.VirologyCharacterization of hepatitis C virus (HCV) and HCV E2 interactions with CD81 and the low-density lipoprotein receptor.20001005510062Monazahian M., Bohme I., Bonk S., Koch A., Scholz C., Grethe S., Thomssen R.J.Med.Virol.Low density lipoprotein receptor as a candidate receptor for hepatitis C virus.1999223229Germi R., Crance J.M., Garin D., Guimet J., Lortat-Jacob H., Ruigrok R.W., Zarski J.P., Drouet E.J.Med.Virol.Cellular glycosaminoglycans and low density lipoprotein receptor are involved in hepatitis C virus adsorption.2002206215
02.8.1999.;Ignatieva E.V.;created
14.10.2004;Khlebodarova T.M.;edited
27.10.2004;Khlebodarova T.M.;edited
 476.151002 449.727540 regulatory eventincreasedirectexperimentalCD209 antigenHomo sapienshumanLozach P.Y., Lortat-Jacob H., de Lacroix de Lavalette A., Staropoli I., Foung S., Amara A., Houles C., Fieschi F., Schwartz O., Virelizier J.L., Arenzana-Seisdedos F., Altmeyer R.J.Biol.Chem.DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2.20032035820366Pohlmann S., Zhang J., Baribaud F., Chen Z., Leslie G.J., Lin G., Granelli-Piperno A., Doms R.W., Rice C.M., McKeating J.A.J.VirologyHepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.200340704080Cormier E.G., Durso R.J., Tsamis F., Boussemart L., Manix C., Olson W.C., Gardner JP., Dragic T.Proc.Natl.Acad.Sci.USAL-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.20041406714072
14.10.2004;Khlebodarova T.M.;edited
29.10.2004;Khlebodarova T.M.;edited
14.10.2004;Khlebodarova T.M.;created
 454.148193 441.164490 regulatory eventincreasedirectexperimentalCD209 antigen-like protein 1 Homo sapienshumanPohlmann S., Zhang J., Baribaud F., Chen Z., Leslie G.J., Lin G., Granelli-Piperno A., Doms R.W., Rice C.M., McKeating J.A.J.VirologyHepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.200340704080Gardner J.P., Durso R.J., Arrigale R.R., Donovan G.P., Maddon P.J., Dragic T., Olson W.C.Proc.Natl.Acad.Sci.USAL-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus.200344984503Cormier E.G., Durso R.J., Tsamis F., Boussemart L., Manix C., Olson W.C., Gardner JP., Dragic T.Proc.Natl.Acad.Sci.USAL-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.20041406714072Lozach P.Y., Lortat-Jacob H., de Lacroix de Lavalette A., Staropoli I., Foung S., Amara A., Houles C., Fieschi F., Schwartz O., Virelizier J.L., Arenzana-Seisdedos F., Altmeyer R.J.Biol.Chem.DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2.20032035820366
14.10.2004;Khlebodarova T.M.;created
14.10.2004;Khlebodarova T.M.;edited
29.10.2004;Khlebodarova T.M.;edited
 437.570068 422.144959 irreversible reactiondirectexperimentalHepatitis C virushuman hepatitis C virusHepatitis C virushuman hepatitis C virusKurihara C., Tsuzuki Y., Hokari R., Nakashima H., Mataki N., Kuroki M., Kawaguchi A., Nagao S., Kondo T., Miura S. J.Med.Virol.A highly hydrophobic domain within hypervariable region 1 may be related to the entry of hepatitis C virus into cultured human hepatoma cells.2004546555Drummer H.E., Poumbourios P.J.Biol.Chem.Hepatitis C virus glycoprotein E2 contains a membrane-proximal heptad repeat sequence that is essential for E1E2 glycoprotein heterodimerization and viral entry.20043006630072Hsu M., Zhang J., Flint M., Logvinoff C., Cheng-Mayer C., Rice C.M., McKeating J.A.Proc.Natl.Acad.Sci.USAHepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles.200372717276Keck Z.Y., Sung V.M., Perkins S., Rowe J., Paul S., Liang T.J., Lai M.M., Foung S.K.J.VirologyHuman monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity.200472577263
27.10.2004;Khlebodarova T.M.;edited
12.10.2004;Khlebodarova T.M.;edited
09.11.2004;Khlebodarova T.M.;edited
 597.743714 369.547852 no data reactiondirectexperimentalProtein P7Hepatitis C virushuman hepatitis C virusp7 proteinHepatitis C virushuman hepatitis C virusPavlovic D., Neville D.C., Argaud O., Blumberg B., Dwek R.A., Fischer W.B., Zitzmann N.Proc.Natl.Acad.Sci.USAThe hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.200361046108Premkumar A., Wilson L., Ewart G.D., Gage P.W.FEBS Lett.Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride.200499103Griffin S.D., Beales LP., Clarke D.S., Worsfold O., Evans S.D., Jaeger J., Harris M.P., Rowlands D.J.FEBS Lett.The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.20033438
11.11.2004;Khlebodarova T.M.;edited
19.10.2004;Khlebodarova T.M.;edited
 2463.857178 1588.700806 CD209CD209 antigenDendritic cell-specific ICAM-3-grabbing nonintegrin 1DC-SIGNDC-SIGN1Homo sapienshumanSWISS-PROTQ9NNX6C209_HUMANactivemultimerLozach P.Y., Lortat-Jacob H., de Lacroix de Lavalette A., Staropoli I., Foung S., Amara A., Houles C., Fieschi F., Schwartz O., Virelizier J.L., Arenzana-Seisdedos F., Altmeyer R.J.Biol.Chem.DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2.20032035820366Pohlmann S., Zhang J., Baribaud F., Chen Z., Leslie G.J., Lin G., Granelli-Piperno A., Doms R.W., Rice C.M., McKeating J.A.J.VirologyHepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.200340704080Lozach P.Y., Amara A., Bartosch B., Virelizier J.L., Arenzana-Seisdedos F., Cosset F.L., Altmeyer R.J.Biol.Chem.C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particles.20043203532045Gardner J.P., Durso R.J., Arrigale R.R., Donovan G.P., Maddon P.J., Dragic T., Olson W.C.Proc.Natl.Acad.Sci.USAL-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus.200344984503Wang Q.C., Feng Z.H., Nie Q.H., Zhou Y.X.Chin.Med.J.DC-SIGN: binding receptors for hepatitis C virus.200413951400
12.10.2004;Khlebodarova T.M.;edited
15.11.2004;Khlebodarova T.M.;edited
15.10.2004;Khlebodarova T.M.;edited
 426.000428 528.711426 black lightgrey oval