<gene id="58232AD0-366-4FDC-B745-D646F60C7072">
	<object id="geneID14065"><sn>GBP1</sn><nm>guanylate-binding protein 1</nm><sy>67 kDa guanylate-binding protein 1</sy><sy>Interferon-induced guanylate-binding protein 1</sy><sy>Guanine nucleotide-binding protein 1</sy><os id="organismID953"><Latin>Homo sapiens</Latin><English>human</English></os><ch>1</ch><dbref><name>SWISS-PROT</name><ac>P32455</ac><id>GBP1_HUMAN</id></dbref><dbref><name>TRRD</name><ac>A00200</ac><id>Hs:GBP</id></dbref><dbref><name>GenBank</name><ac>BC002666</ac><id>BC002666</id></dbref><dbref><name>GDB</name><ac>GDB:378351</ac><id>GBP1</id></dbref><pn id="proteinID27569"><sn>GBP</sn><nm>guanylate-binding protein</nm><os id="organismID953"><Latin>Homo sapiens</Latin><English>human</English></os></pn><inducer id="repressor82"><name>IFN-gamma</name></inducer><inducer id="repressor80"><name>IFN-alpha</name></inducer><cell id="cellID4135"><sn>Fibroblast</sn><de>Fibroblasts</de><os id="organismID953"><Latin>Homo sapiens</Latin><English>human</English></os></cell><ref id="690E118D-BD18-4217-B4B9-CC4C20B6C8ED"><authors>Decker T., Lew D.J., Cheng Y.S., Levy D.E., Darnell J.E. Jr.</authors><journal id="journal103"><nm>EMBO J.</nm></journal><title>Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.</title><year>1989</year><pages><first>2009</first><last>2014</last></pages></ref><ref id="42FE8F04-CD14-48A8-9966-3779FCC95DF1"><authors>Decker T., Lew D. J., Darnell J. E.</authors><journal id="journal234"><nm>Mol.Cell.Biol.</nm></journal><title>Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene</title><year>1991</year><pages><first>5147</first><last>5153</last></pages></ref><ref id="3BF823C1-BB42-41D9-BAC0-AA52C886F9B5"><authors>Decker T., Lew D.J., Mirkovitch J., Darnell J.E. Jr.</authors><journal id="journal103"><nm>EMBO J.</nm></journal><title>Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.</title><year>1991</year><pages><first>927</first><last>932</last></pages></ref><ref id="literID14941"><authors>Eilers A., Baccarini M., Horn F., Hipskind R.A., Schindler C. and Decker T.</authors><journal id="journal234"><nm>Mol.Cell.Biol.</nm></journal><title>A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site.</title><year>1994</year><pages><first>1364</first><last>1373</last></pages></ref><ref id="literID39014"><authors>Lew D.J., Decker T., Strehlow I., Darnell J.E.</authors><journal id="journal234"><nm>Mol.Cell.Biol.</nm></journal><title>Overlapping elements in the guanilate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.</title><year>1991</year><pages><first>182</first><last>191</last></pages></ref><ref id="EFF41C61-B6A4-40A0-B263-60F26C61D09E"><authors>Lew D.J., Decker T., Darnell J.E. Jr.</authors><journal id="journal234"><nm>Mol.Cell.Biol.</nm></journal><title>Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.</title><year>1989</year><pages><first>5404</first><last>5411</last></pages></ref><ref id="62993FFC-2873-4079-ABCA-184DC26EC6B9"><authors>Mirkovitch J., Decker T., Darnell J.E. Jr.</authors><journal id="journal234"><nm>Mol.Cell.Biol.</nm></journal><title>Interferon induction of gene transcription analyzed by in vivo footprinting.</title><year>1992</year><pages><first>1</first><last>9</last></pages></ref><ref id="B2BC3EEF-ECCD-46B5-863C-DE4FC8F0AB6D"><authors>Nees M., Geoghegan J.M., Hyman T., Frank S., Miller L., Woodworth C.D.</authors><journal id="journal211"><nm>J.Virology</nm></journal><title>Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes.</title><year>2001</year><pages><first>4283</first><last>4296</last></pages></ref><ref id="455BC3B7-7816-438A-BEDC-89DC2B25C35D"><authors>Seegert D., Strehlow I., Klose B., Levy D.E., Schindler C., Decker T.</authors><journal id="journal167"><nm>J.Biol.Chem.</nm></journal><title>A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene.</title><year>1994</year><pages><first>8590</first><last>8595</last></pages></ref><ref id="2EA13C5A-637C-4935-8ADE-A44DF4E52605"><authors>Yamagata T., Nishida J., Tanaka T., Sakai R., Mitani K., Yoshida M., Taniguchi T., Yazaki Y., Hirai H.</authors><journal id="journal234"><nm>Mol.Cell.Biol.</nm></journal><title>A novel Interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes</title><year>1996</year><pages><first>1283</first><last>1294</last></pages></ref><dt>15.12.2002;Ananko E.;created</dt><dt>08.10.2004;Ananko E.A.;edited</dt></object>
	<x>798.418703</x>
	<y>665.209597</y>
</gene>
