NS5ANonstructural protein NS5Ap56Hepatitis C virushuman hepatitis C virusSWISS-PROTP26664POLG_HCV1activeno dataTellinghuisen T.L., Marcotrigiano J., Gorbalenya A.E., Rice C.M.J.Biol.Chem.The NS5A protein of hepatitis C virus is a zinc metalloprotein.2004143Shirota Y., Luo H., Qin W., Kaneko S., Yamashita T., Kobayashi K., Murakami S.J.Biol.Chem.Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity.20021114911155Elazar M., Cheong K.H., Liu P., Greenberg H.B., Rice C.M., Glenn J.S.J.VirologyAmphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication.200360556061Locarnini S.A., Bartholomeusz A.J.Gastroenterol.Hepatol.Advances in hepatitis C: what is coming in the next 5 years?2002442447Brass V., Bieck E., Montserret R., Wolk B., Hellings J.A., Blum H.E., Penin F., Moradpour D.J.Biol.Chem.An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A.200281308139Gale M. Jr., Blakely C.M., Kwieciszewski B., Tan S.L., Dossett M., Tang N.M., Korth M.J., Polyak S.J., Gretch D.R., Katze M.G.Mol.Cell.Biol.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.199852085218Geiss G.K., Carter V.S., He Y., Kwieciszewski B.K., Holzman T., Korth M.J., Lazaro C.A., Fausto N., Bumgarner R.E., Katze M.G.J.VirologyGene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.200363676375The PKR-binding domain of NS5A is localized to within the ISDR (IFN sensitivity-determining region, aa 2209 to 2248).Gale M. Jr., Blakely C.M., Kwieciszewski B., Tan S.L., Dossett M., Tang N.M., Korth M.J., Polyak S.J., Gretch D.R., Katze M.G.Mol.Cell.Biol.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.199852085218At least 200 genes were differentially regulated in response to NS5A expression.Geiss G.K., Carter V.S., He Y., Kwieciszewski B.K., Holzman T., Korth M.J., Lazaro C.A., Fausto N., Bumgarner R.E., Katze M.G.J.VirologyGene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.200363676375Several signaling pathways were affected by NS5A expression. NS5A appeared to have a significant effect on calcium signaling.Geiss G.K., Carter V.S., He Y., Kwieciszewski B.K., Holzman T., Korth M.J., Lazaro C.A., Fausto N., Bumgarner R.E., Katze M.G.J.VirologyGene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.200363676375
01.10.2004;Ananko E.A.;created
04.10.2004;Khlebodarova T.M.;edited
04.10.2004;Ananko E.A.;edited
12.10.2004;Ananko E.A.;edited
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