SK6p70 ribosomal protein S6 kinaseEC 2.7.1.37RPS6KB1p70-S6KHomo sapienshumanSWISS-PROTP23443K6B1_HUMANactivephosphorylatedno dataPullen N., Dennis P.B., Andjelkovic M., Dufner A., Kozma S.C., Hemmings B.A., Thomas G.SciencePhosphorylation and activation of p70s6k by PDK1.1998707710 Activation of the kinase requires hierarchical phosphorylation at multiple sites, culminating in the phosphorylation of the threonine in position 229 (Thr229), in the catalytic domain by PDK1. The phosphorylation of Thr229 appears to depend on phosphorylation of Thr389, and this reaction is facilitated by converting four (Ser/Thr)-Pro phosphorylation sites in the autoinhibitory domain to acidic residues.
06.11.2002;Alena N.;created
07.10.2004;Khlebodarova T.M.;edited
 1992.273937 704.225922