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(Interferon-Inducible Genes Transcription Regulatory Regions Database)
is developed by Elena A. Ananko, Sergey I. Bazhan and Olga E. Belova

Interferons act through specific cell-surface receptors to modulate the expression of different cellular genes whose encoded products profoundly affect a number of important biological functions including antiviral inflammatory and immune responses, cell growth and differentiation.

Interferons are classified into two distinct types, designated as type I (IFN-alpha, IFN-beta, IFN-omega, IFN-tau) and type II (IFN-gamma) according to their cellular origin, inducing agents and antigenic and functional properties.



Gene name Gene name synonym Organism TRRD AC
Interferon-alpha1 IFN A1 Homo sapiens A00273
Interferon-A11 IFN-A11 Mus musculus A00460
Interferon-A4 IFN-A4 Mus musculus A00519
Interferon-alpha IFN-alpha Mus musculus A00391
Interferon-beta IFN-beta Homo sapiens A00274
Interferon-beta virus-induced interferon-beta Mus musculus A00039
Interferon-gamma IFN-gamma Homo sapiens A00375

Transcription factors

Gene name Gene name synonym Organism TRRD AC
Hepatocyte nuclear factor 3-beta HNF3B Rattus norvegicus A00383
Integral component of the multimeric transcription factor ISGF3 gamma subunit p48, ISGF3gamma, interferon-stimulated gene factor 3 gamma Mus musculus A00891
Interferon regulatory factor 1 IRF-1, ISGF2 Homo sapiens A00276
Interferon regulatory factor 1 IRF-1 Mus musculus A00281
Interferon regulatory factor 7 IRF-7 Homo sapiens A01777
Interferon consensus sequence binding protein ICSBP Mus musculus A00219
Interferon regulatory factor 2 IRF-2 Homo sapiens A00277
p50 subunit of Nuclear Factor kappa B p105 Homo sapiens A00117
Signal Transducer and Activator of Transcription 1 STAT1 Homo sapiens A01784
Signal Transducer and Activator of Transcription 2 STAT2 Homo sapiens A00458

Regulatory proteins

Gene name Gene name synonym Organism TRRD AC
C1 inhibitor C1INH Homo sapiens A00357
Complement factor B Bf Homo sapiens A00341
Cytosolic phagocyte oxidase protein p47phox Homo sapiens A00731
Eosinophil chemotactic protein SCYA11 Homo sapiens A02212
Ifi 202 202 gene Mus musculus A00284
Ifi 204 204 gene Mus musculus A00285
Inflammatory protein 10-kDa IP-10 Mus musculus A00385
Inflammatory protein 10-kDa IP-10 Homo sapiens A00927
Interleukin-1beta IL1B Homo sapiens A00113
Interleukin-12 alpha chain IL-12A Homo sapiens A02231
Interleukin-12 beta chain IL-12B Mus musculus A02232
Interleukin-18 IL-18, interferon-gamma-inducing factor Mus musculus A01373
Interleukin-6 IL-6 Homo sapiens A00115
Interleukin-8 IL-8 Homo sapiens A00038
Macrophage inflammatory protein 1 alpha MIP-1 alpha, GOS19.1, SCYA3, MIP1A Homo sapiens A00989
Macrophage inflammatory protein 1 alpha MIP-1 alpha SCI, TY-5, SIS-alpha, heparin-binding chemotaxis protein, SCYA3, MIP1A Mus musculus A00990
Major histocompatibility complex class II transactivator CIITA Homo sapiens A01150
Monocyte chemotactic protein 4 MCP-4 Homo sapiens A02210
Monocyte chemotactic protein 3 MCP-3 Homo sapiens A02211
Monokine induced by gamma interferon mig Mus musculus A00303
Mx protein Mx Gallus gallus A00331
Mx1 protein Mx1 Mus musculus A00702
MxA protein MxA, IFI-78 Homo sapiens A00703
p21 Waf1 kinase inhibitor Cdk-interacting protein 1 Homo sapiens A00359
Regulated on Activation Normal T cell Expressed and Secreted RANTES Homo sapiens A01781
Serine protease inhibitor 2.1 Spi 2.1 Rattus norvegicus A00105
TNF-related apoptosis-inducing ligand TRAIL Mus musculus A02033
Vascular endothelial growth factor A precursor VEGFA Homo sapiens A02182
Tumor necrosis factor alpha TNF-alpha Homo sapiens A00266


Gene name Gene name synonym Organism TRRD AC
2'-5' oligoadenylate synthetase 2'-5' A synthetase, OAS Homo sapiens A00269
2'-5' oligoadenylate synthetase 2'-5' A synthetase, OAS Mus musculus A00286
Acyl-coenzyme A:cholesterol acyltransferase 1 ACAT-1 Homo sapiens A01782
Cytochrome b558 heavy chain gene flavocytochrome, b558, NADPH-dependent oxidase, heavy chain phagocyte, NADPH oxidase, flavocytochrome b-245 heavy chain phagocyte, NADPH oxidase heavy chain, heavy chain of the phagocyte respiratory burst oxidase Homo sapiens A00991
Cytochrome b558 67 kDa cytosolic component flavocytochrome b558 NADPH-dependent oxidase cytosolic component, phagocyte NADPH oxidase flavocytochrome b -245 cytosolic component, phagocyte NADPH oxidase cytosolic component, cytosolic component of the phagocyte respiratory burst oxidase Homo sapiens A00993
dsRNA-dependent eIF-2alpha protein kinase PKR, dsRNA-dependent cAMP-independent protein serine/threonine kinase Mus musculus A00372
Gene associated with retinoid-IFN-induced mortality 19 GRIM19 Homo sapiens A01518
Indoleamine 2,3-dioxygenase IDO Homo sapiens A00358
Inducible nitric oxide synthase NO synthase inducible form, macrophage nitric-oxide synthase, nitric-oxide synthase type 2, type II NOS Gallus gallus A01138
Manganese-containing superoxide dismutase MnSOD Rattus norvegicus A01350
Nitric oxide synthase inducible nitric oxide synthase, NOS2, hiNOS, inducible NOS, macrophage-type NOS, iNOS, NOS, type II, NOS2A, hepathocyte NOS, hep-NOS Homo sapiens A01197
Nitric oxide synthase iNOS, NO synthase inducible form, mac-NOS Mus musculus A00304
Nitric oxide synthase iNOS, inducible nitric oxide synthase, NO synthase, NOS II, NOS2, nos2 Rattus norvegicus A01053
Phospholipase C-gamma-1 PLCG1 Homo sapiens A01622
Stromelysin STROM Homo sapiens A00214
Tryptophanyl-tRNA synthetase IFP-53 Homo sapiens A00201


Gene name Gene name synonym Organism TRRD AC
Angiotensin II receptor type 2 gene AGTR2 Mus musculus A01080
Fas ligand receptor Fas antigen, apoptosis-mediating surface antigen, FAS, cell surface receptor for an apoptosis-mediating signal molecule Fas-ligand, APO-1 antigen, CD95 antigen, APT1 Homo sapiens A01081
Fas ligand receptor FASL receptor, Fas antigen, Fas death receptor, APO-1 antigen, CD95 antigen, TNFRSF6, APT1, FAS Mus musculus A01133
High affinity IgG receptor Fc gamma RI Homo sapiens A00199
High affinity IgG receptor Fc gamma RI Mus musculus A00230
Low affinity receptor for Fc domain of IgG Fc gammaRIII-B Homo sapiens A00796
Low affinity receptor for Fc domain of IgG Fc gammaRIII-A Mus musculus A00794
Platelet activating factor receptor PTAFR Homo sapiens A00928
Polymeric immunoglobulin receptor poly-Ig receptor transmembrane secretory component Homo sapiens A01082

Nucleotide-Binding Proteins

Gene name Gene name synonym Organism TRRD AC
Guanylate-binding protein-1 Gbp-1, mag-1, macrophage activation gene-1 Mus musculus A00231
Guanylate-binding protein-2 Gbp-2, mGBP-2 Mus musculus A00291
Guanylate-binding protein GBP Homo sapiens A00200
Interferon-induced RNA binding protein 9-27 9-27 Homo sapiens A00271
Interferon regulatory gene 47 for guanine nucleotide binding protein IRG-47 G Mus musculus A00975

Lymphocyte Antigens

Gene name Gene name synonym Organism TRRD AC
Ly-6E differentiation antigen Ly-6A/E Mus musculus A00283
Ly-6E.1 differentiation antigen Sca-1 Mus musculus A00890
Lymphocyte antigen Ly-6E Ly-6E Homo sapiens A00280


Gene name Gene name synonym Organism TRRD AC
Immunoglobulin germline kappa gene Ig germline kappa Mus musculus A00921
Immunoglobulin germline kappa C region Ig mu-chain C region, germline Ig kappa C Mus minutoides A00923
Immunoglobulin kappa constant region Ig kappa C, Ig kappa light chain C region Mus musculus A00922

Major Histocompatibility Complex Class I

Gene name Gene name synonym Organism TRRD AC
HLA-Aw24   Homo sapiens A00186
HLA-A3   Homo sapiens A00342
HLA-A11   Homo sapiens A00459
HLA-B7   Homo sapiens A00185
H-2Dd   Mus musculus A00234
H-2Kk   Mus musculus A00236
H-2Kb   Mus musculus A00235
H-2Ld   Mus musculus A00237

Major Histocompatibility Complex Class II

Gene name Gene name synonym Organism TRRD AC
HLA-DPA DP-alpha Homo sapiens A00204
HLA-DPB DP-beta Homo sapiens A00205
HLA-DQA DQ-alpha Homo sapiens A00206
HLA-DQB DP-beta Homo sapiens A00207
HLA-DRA DR-alpha Homo sapiens A00077
HLA-DRB DR-beta Homo sapiens A00208
Invariant chain In Homo sapiens A00275
Invariant chain Ii Mus musculus A00126
A beta d   Mus musculus A00225
E alpha d   Mus musculus A00224
E alpha k   Mus musculus A00226
E beta   Mus musculus A00239
E beta d   Mus musculus A00227
Ia A alpha d   Mus musculus A00238
Ia A alpha   Mus musculus A00240

Adhesion Molecules

Gene name Gene name synonym Organism TRRD AC
Biliary glycoprotein BGP, CD66A antigen Homo sapiens A00748
Intercellular adhesion molecule-1 ICAM-1 Homo sapiens A00302
Vascular cell adhesion molecule 1 VCAM-1, cytokine-inducible adhesion molecule Homo sapiens A00301


Gene name Gene name synonym Organism TRRD AC
Interferon-activatable protein 205 IFI-205, D3 Mus musculus A01327
Acid cytokeratin K17 K17 Homo sapiens A00333
Alpha1-acid glycoprotein AGP Rattus norvegicus A00121
Alpha2-macroglobulin A2-Mag Rattus norvegicus A00257
beta-R1/I-TAC interferon-inducible T-cell alpha-chemoattractant Homo sapiens A01148
Hepatitis-C-associated microtubular aggregate protein p44 Homo sapiens A00340
IFN-gamma-inducible gene IFI 16 IFI 16 Homo sapiens A00902
Immunostimulatory 90K antigen tumor-associated antigen 90K, MAC-2 binding protein, immunostimulatory glycoprotein Homo sapiens A01070
Immunostimulatory 90K antigen immunostimulatory 90K antigen, tumor-associated antigen, 90K immunostimulatory glycoprotein Mus musculus A01120
Interferon-inducible gene IFI-56K IFI-56K Homo sapiens A00272
Interferon-stimulated gene 54 ISG54, IFI-54K Homo sapiens A00279
Interferon-stimulated gene 15 ISG15, IFI-15K Homo sapiens A00278
Interferon-induced gene 6-16 6-16 Homo sapiens A00270
Involucrin IVL Homo sapiens A02122
Metallothionein IIA MT-IIA Homo sapiens A00071
Metallothionein-I MT-I Mus musculus A00080
Monocyte chemoattractant protein 1 Monocyte chemoattractant, adn, activating factor, tumor-derived chemotactic factor, smooth muscle cell chemoattractant factor Homo sapiens A00892
Nuclear domain-associated protein Sp100 Sp100 Homo sapiens A01004
Pro-Myelocytic Leukemia PML Homo sapiens A00951
S100 calcium-binding protein A4 malignant transformation suppression 1, mts1, CAPL Mus musculus A00742
Thrombospondin 1 TSP 1 Homo sapiens A00847
Vimentin VIM Homo sapiens A02181