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Apoptosis Genes (Apoptosis - TRRD)

Irina L. Stepanenko  e-mail:

Apoptosis (programmed cell death) is one of the variations of physiological cell death indicated by recognizable morphological changes (cell shrinkage, membrane blebbing, and DNA fragmentation). Apoptosis is a conservative, highly regulated mechanism for elimination of cells that impair proper functioning of an organism. Apoptosis is critical for normal development during embryogenesis, maintenance of tissue homeostasis, and protection from autoreactive T-lymphocytes, virus-infected cells, and tumor cells.

TRRD gene name Species Gene name synonym TRRD AC
Death ligands
CD95 ligand Homo sapiens FAS ligand A00518
tumor necrosis factor alpha Homo sapiens TNF-alpha, cachectin A00266
Death receptors
Fas ligand receptor Mus musculus Fas antigen, Fas death receptor, APO-1 antigen, CD95 antigen, TNFRSF6, APT1, FAS A01133
Fas ligand receptor Homo sapiens Fas antigen, cell surface receptor for an apoptosis-mediating signal molecule Fas-ligand, APO-1 antigen, CD95 antigen, APT1 A01081
caspase 9 Rattus norvegicus   A01562
caspase 1 Homo sapiens interleukin-1 beta converting enzyme, interleukin-1beta convertase, IL-1BC, IL-1 beta converting enzyme, ICE, P45, CASP-1, IL1BC, IL1BCE A01561
Apoptosis Inhibitors
apoptosis inhibitor survivin Homo sapiens baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, BIRC5, API4, IAP4 A01163
apoptosis inhibitor survivin Mus musculus baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, TIAP, BIRC5, API4, IAP4 A01160
cellular inhibitor of apoptosis protein 2 Homo sapiens

TNFR2-TRAF signaling complex protein 1, IAP homolog C, HIAP-1, MIHC, BIRC2, API1, MIHC, Baculoviral IAP repeat-containing protein 1

HSP90beta Homo sapiens A00180
HSP89alpha Homo sapiens HSP90A, HSPCA A00562
heat shock protein 27 Homo sapiens HSP27, HSPB1, HSP28, SRP27 A00516
heat shock protein 70 Homo sapiens HSP70.1, HSP70-1/HSP70-2, HSPA1A,  HSPA1,  HSPA1B A00102
Bcl-2 family proteins
Apoptosis regulator Bcl-2 Homo sapiens bcl-2 A01481
BCL2-associated X protein Mus musculus BAX A01447
BCL2-associated X protein Homo sapiens Apoptosis regulator BAX A01241
bcl-x Mus musculus A01380
early gene induced during differentiation of ML-1 myeloid leukemia cells Mus musculus MCL-1 A01217
Transcription factors and its regulators
activating transcription factor 3 Homo sapiens   A01480
c-fos protooncogene Homo sapiens p55-c-fos proto-oncogene protein, cellular oncogene c-fos, G0S7 protein, FOS A00110
c-fos protooncogene Mus musculus p55-c-fos proto-oncogene protein, cellular oncogene c-fos, FOS A00107
c-jun protooncogene Homo sapiens transcription factor AP-1, P39, G0S7, JUN A00182
c-myc protooncogene Homo sapiens C-MYC, MYC A00191
c-myc protooncogene Mus musculus C-MYC, MYC A00108
p53 tumor suppressor Homo sapiens cellular tumor antigen P53, tumor suppressor p53, phosphoprotein, P53, TP53 A00307
p53 tumor suppressor Mus musculus cellular tumor antigen P53, tumor suppressor p53, phosphoprotein, P53, TP53 A00308
Max Interactor 1 Homo sapiens MXI1 A01251
mdm2 proto-oncogene Mus musculus DOUBLE MINUTE 2, ubiquitin-protein ligase E3 MDM2 A00438
NF-kappaB inhibitor alpha Homo sapiens Major histocompatibility complex enhancer-binding protein MAD3, I-kappa-B-alpha, IkappaBalpha, IKB-alpha, NFKBIA, NFKBI, MAD3, IKBA, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, MAD-3 A01357
oncogene junB Mus musculus transcription factor JUN-B,   JUNB, JUN-B A00095
retinoblastoma Homo sapiens RB1 A00329
Other genes
A20 Homo sapiens zinc finger protein A20 A00034
adenine nucleotide translocator 2 Homo sapiens SLC25A5, adenine nucleotide translocase 2, ANT2 A01252
Cu/Zn  superoxide dismutase Rattus norvegicus SOD1 A01183
Cu/Zn superoxide dismutase Homo sapiens SOD1 A00564
etoposide induced protein 2.4 Mus musculus PIG8, EI24 A01144
eyes absent Drosophila melanogaster eye, clift, cli, CG9554 A00907
cytosolic glutathione peroxidase Mus musculus GSHPX-1, cellular glutathione   peroxidase, GPX1 A00463
placental transforming growth factor beta Homo sapiens GDF15, PTGFB, MIC1, PDF A01302
fibrinogen-like protein 2 Mus musculus FIBLP, Fibroleukin precursor,Prothrombinase, Cytotoxic T-lymphocyte specific protein A01334
extracellular signal-regulated protein kinase 2 Mus musculus p42 MAP kinase A01595
gene associated with retinoid-IFN-induced mortality 19 Homo sapiens NADH-ubiquinone oxidoreductase B16.6 subunit, Complex I-B16.6, CI-B16.6, Gene associated with retinoic-interferon-induced mortality 19 protein, Cell death-regulatory protein GRIM-19, CGI-39, CDA016, GRIM-19 A01518

glucose-regulated protein 78

Rattus norvegicus

GRP 78, immunoglobulin heavy chain binding protein, BiP, steroidogenesis-activator polypeptide, HSPA5

glutathione transferase P Homo sapiens GST class-PI, GSTP1-1, GSTP1, GST3 A00030
glutathione transferase P Rattus norvegicus GST class-PI A00262
granulocyte/macrophage colony stimulating factor Mus musculus GM-CSF, colony-stimulating factor, CSF, CSF2,  CSFGM A00451
granulocyte/macrophage colony stimulating factor Homo sapiens GM-CSF, colony-stimulating factor, CSF, sargramostim, molgramostin, CSF2, GMCSF A00450
growth arrest and DNA damage-inducible Cricetulus longicaudatus GADD153, DNA-damage inducible transcript 3, DDIT3, C/EBP-homologous protein, CHOP, TLS-CHOP A00960
growth arrest and DNA-damage-inducible protein GADD45A Homo sapiens GADD45 A01473
hsr203J Nicotiana tabacum A01504
inducible nitric oxide synthase Rattus norvegicus NOS, TYPE II inducible NOS, INOS, NOS2 A01053
inducible nitric oxide synthase Gallus gallus NO synthase inducible form, macrophage nitric-oxide synthase, nitric-oxide synthase type 2, type II NOS A01138
inducible nitric oxide synthase Homo sapiens NOS2, hiNOS, inducible NOS, macrophage-type NOS, iNOS, NOS, type II, NOS2A, hepathocyte NOS, hep-NOS A01197
inducible nitric oxide synthase Rattus norvegicus
NO synthase, NOS II, NOS2, nos2

intercellular adhesion molecule-1 Homo sapiens major group rhinovirus receptor, CD54, ICAM1 A00302
intercellular adhesion molecule-1 Mus musculus ICAM1, ICAM-1, MALA-2 A01000
interleukin-1beta Mus musculus IL-1 beta A00461
interleukin 6 Homo sapiens IL-6, B-cell stimulatory factor 2, BSF-2, interferon beta-2, IFNB2, hybridoma growth factor A00115
interleukin-8 Homo sapiens IL-8, monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, neutrophil-activating protein 1, NAP-1, lymphocyte-derived neutrophil-activating factor, LYNAP, protein 3-10C, neutrophil-activating factor, NAF, granulocyte chemotactic protein 1, GCP-1, emoctakin A00038
macrophage inflammatory protein 1 alpha Mus musculus small inducible cytokine a3 precursor, MIP-1-ALPHA, SCI, TY-5, SIS-alpha, heparin-binding chemotaxis protein, SCYA3, MIP1A A00990
macrophage inflammatory protein 1 alpha Homo sapiens GOS19A, GOS19.1, MIP-1 alpha, SCYA3, MIP1A A00989
macrophage inflammatory protein-1 beta
Homo sapiens MIP-1-beta, small inducible cytokine A4 precursor, T-cell activation protein 2, ACT-2, lymphocyte activation gene-1 protein, LAG-1, G-26 T lymphocyte-secreted protein, SCYA4 A00194
manganese-containing superoxide dismutase Homo sapiens SOD2, MnSOD A01087
multidrug resistance Homo sapiens MDR1, P-glycoprotein 1, PGY1, ABCB1 A00171
multidrug resistance 1b Rattus norvegicus MDR1B, MDR1, P-glycoprotein 1, PGY1, PGY1-1, ABCB1 A00662
multidrug resistance gene 1b Mus musculus MDR1, MDR1B, P-glycoprotein 1, PGY1, PGY1-1, ABCB1 A00172
NAD(P)H:quinone oxidoreductase Homo sapiens NAD(P)H dehydrogenase 1, quinone reductase 1,QR1, DT-diaphorase, DTD, azoreductase, phylloquinone reductase,menadione reductase, DIA4, NMOR1, NQO1 A01011
nitric oxide synthase Mus musculus nitric oxide synthase, inducible, NOS, TYPE II, inducible NOS, INOS, macrophage NOS, MAC-NOS,  NOS2,  INOSL A00304
p21 Waf1 kinase inhibitor Homo sapiens cyclin-dependent kinase inhibitor 1, melanoma differentiation associated protein 6, MDA-6, P21, CDK-interacting protein 1, CDKN1A, CDKN1, CIP1, WAF1, MDA6, SDI1, PIC1, CAP20 A00359
p53 induced Homo sapiens PIG3, NADPH quinone oxidoreductase homolog A01112
presenilin 1 Homo sapiens PSEN1, PSNL1, AD3, PS1 A01438
prointerleukin-1beta Homo sapiens IL-1 beta,  IL1B, catabolin A00263
tartrate-resistant acid phosphatase Mus musculus TR-AP, tartrate-resistant acid atpase, tratpase,  ACP5, TRAP, T5AP A00741
thioredoxin Homo sapiens

ATL-derived factor, ADF, Surface associated sulphydryl protein, SASP, TXN, TRDX, TRX1

tyrosine phosphatase Homo sapiens dual specificity protein phosphatase 1, MAP kinase phosphatase-1, MKP-1, protein-tyrosine phosphatase, CL100, dual specificity protein phosphatase HVH1, DUSP1, PTPN10, MKP1, VH1 PRL-1 A00666