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HCV-TRRD
Hepatitis C virus-induced genes

 (HCV-associated genes)

Irina L. Stepanenko  e-mail: stepan@bionet.nsc.ru

 TRRD gene name

 gene name synonyms

 function/process

 TRRD AC

2'-5' oligoadenylate synthetase OAS, 2'-5' A synthetase gene, 2'-5'-oligoadenylate synthetase 1, (2-5')oligo(A) synthetase 1, 2-5A synthetase 1, p46/p42 OAS, E18/E16, OAS1, OIAS inflammatory process, enzyme, IFN-inducible A00269

78-kD glucose-regulated protein

BiP, HSPA5, grp78

molecular chaperone

A00576

94 kDa glucose-regulated protein

grp94, TRA1, Tumor rejection antigen 1

molecular chaperone

A02234

A20

zinc finger protein A20

apoptosis, immune response

A00034

activating transcription factor 3

ATF3

apoptosis, transcription factor

A01480

adenine nucleotide translocator 2

SLC25A5, ANT2, adenine nucleotide translocase 2

apoptosis, metabolism

A01252

adenomatous polyposis coli

APC

apoptosis, oncogene

A01851

albumin

ALB

tansport protein

A00183

Aldehyde dehydrogenase 1

ALDH1, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase, cytosolic ALDH class 1, ALHDII, ALDH-E1, ALDH1A1, ALDC

oxidative stress, hepatocarcinoma-associted

A02269

alpha platelet-derived growth factor receptor 

 PDGFRA, PDGF-R-alpha, CD140a antigen

differentiation

 A02035

alpha-fetoprotein

AFP

tansport protein

A00192

annexin A5

 Lipocortin V, ANX5, ENX2, PP4

calcium binding protein , inflammatory process

 A01871

apoptosis inhibitor survivin

baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, BIRC5, API4, IAP4

apoptosis

A01163

Apoptosis regulator Bcl-2

bcl-2

apoptosis

A01481

Apoptotic protease activating factor-1

Apaf1, KIAA0413

apoptosis

A01639

BCL2-associated X protein

Apoptosis regulator BAX

apoptosis

A01241

bone sialoprotein

Osteopontin, Bone sialoprotein 1, Urinary stone protein, Secreted phosphoprotein 1, SPP-1, Nephropontin, Uropontin, SPP1, OPN

immune response, NS5A-regulated

A02357

caspase-1

interleukin-1 beta converting enzyme, interleukin-1beta convertase, IL-1BC, IL-1 beta converting enzyme, ICE, P45, CASP-1, IL1BC, IL1BCE

apoptosis, inflammatory process, IFN-inducible

A01561

catalase

CAT

detoxification

A01837

caveolin

 

cholesterol transport, cell adhesion and motility

A00611

CD30 ligand receptor

Lymphocyte activation antigen CD30, KI-1 antigen, Tumor necrosis factor receptor superfamily member 8, TNFRSF8, CD30

immune response, apoptosis

A02134

CD95 ligand

FAS ligand

apoptosis, immune response

A00518

cdc2

p34 cdc2 gene, cyclin-dependent kinase 1 gene, p34 serine-threonine kinase 

cell cycle

A00355

cell division cycle 25C

cdc25C, cdc25C protein phosphatase gene, M-phase inducer phosphatase 3

cell cycle

A00354

cellular inhibitor of apoptosis protein 2

TNFR2-TRAF signaling complex protein 1, IAP homolog C, HIAP-1, MIHC, BIRC2, API1, MIHC, Baculoviral IAP repeat-containing protein 1

apoptosis 

A01593

c-fos protooncogene

p55-c-fos proto-oncogene protein, cellular oncogene c-fos, G0S7 protein, FOS

transcription factor, cellular proliferation

A00110

c-jun protooncogene

transcription factor AP-1, P39, G0S7, JUN

transcription factor, cellular proliferation

A00182

clusterin

apoJ,  TRPM-2, SGP-2

lipid metabolism, apoptosis

A00885

c-myc protooncogene

C-MYC, MYC

apoptosis, transcription factor

A00191

Cu/Zn superoxide dismutase

SOD1

apoptosis, detoxification

A00564

cyclin D1

cycD1

cell cycle

A00352

Double-stranded RNA-specific adenosine deaminase

DRADA, 136 kDa double-stranded RNA binding protein, P136,  K88DSRBP, Interferon-inducible protein 4, IFI-4 protein, ADAR, DSRAD, IFI4

double-stranded RNA binding

A02446

epidermal growth factor receptor

Receptor tyrosine-protein kinase ErbB-1, EGFR, ERBB1

hepatocarcinoma-associted, NS5A-regulated

A00197

Fas ligand receptor

Fas antigen, cell surface receptor for an apoptosis-mediating signal molecule Fas-ligand, APO-1 antigen, CD95 antigen, APT1

apoptosis, immune response

A01081

gene associated with retinoid-IFN-induced mortality 19

NADH-ubiquinone oxidoreductase B16.6 subunit, Complex I-B16.6, CI-B16.6, Gene associated with retinoic-interferon-induced mortality 19 protein, Cell death-regulatory protein GRIM-19, CGI-39, CDA016, GRIM-19

apoptosis, immune response

A01518

glutathione transferase P

GST class-PI, GSTP1-1, GSTP1, GST3

apoptosis, detoxification

A00030

granulocyte/macrophage colony stimulating factor

GM-CSF, colony-stimulating factor, CSF, sargramostim, molgramostin, CSF2, GMCSF

apoptosis, immune response

A00450

gro-alpha

 

immune response, NS5A-regulated

A00066

growth arrest and DNA-damage-inducible protein DDIT3

CHOP, GADD153, C/EBP-homologous protein GADD153, DNA-damage inducible transcript 3

apoptosis, transcription factor, ER stress

A02286

growth arrest and DNA-damage-inducible protein GADD45A

GADD45

apoptosis 

A01473

guanylate-binding protein

67 kDa guanylate-binding protein 1,  Interferon-induced guanylate-binding protein 1, Guanine nucleotide-binding protein 1, GBP1

immune response, IFN-inducible, NS5A-regulated

A00200

heat shock protein 27

HSP27, HSPB1, HSP28, SRP27

apoptosis, molecular chaperone

A00516

heat shock protein 70

HSP70.1, HSP70-1/HSP70-2, HSPA1A,  HSPA1,  HSPA1B

apoptosis, molecular chaperone

A00102

heat shock protein 90 A

HSP90A, HSPCA, HSP89alpha

apoptosis, molecular chaperone

A00562

heat shock protein 90 B

HSP90beta

apoptosis, molecular chaperone

A00180

hepatocyte growth factor receptor precursor

MET, c-MET, Met proto-oncogene tyrosine kinase,  HGF receptor, HGF-SF receptor

apoptosis, oncogene, cellular proliferation

A01930

IFN-gamma-inducible gene IFI 16

 

cellular proliferation, nuclear protein, IFN-inducible

A00902

immediate-early response factor X-1

Radiation-inducible immediate-early gene IEX-1, PACAP-responsive gene 1 protein, Differentiation-dependent gene 2 protein, Dif-1, PRG1, Immediate early protein GLY96, Immediate early response 3 protein, IER3

apoptosis

A02440

inducible nitric oxide synthase

NOS2, hiNOS, inducible NOS, macrophage-type NOS, iNOS, NOS, type II, NOS2A, hepathocyte NOS, hep-NOS

apoptosis, immune response, oxidative stress

A01197

intercellular adhesion molecule-1

major group rhinovirus receptor, CD54, ICAM1

apoptosis, immune response

A00302

interferon regulatory factor 1

IRF-1, ISGF2 gene, MAR

transcription factor, immune response, IFN-inducible

A00276

interferon stimulated gene 20KD

nuclear bodies-associated protein PML-NBs, HEM45

immune response, NS5A-regulated

A02375

interferon-induced gene 6-16

6-16, interferon-induced gene 6-16, Ifi-6-16, G1P3

immune response, IFN-inducible

A00270

interferon-inducible gene IFI-56K

IFI-56K, interferon-inducible gene IFI-56K, ISG56, IFIT1, IFI56, G10P1

immune response, IFN-inducible

A00272

interferon-regulated resistance GTP-binding protein MxA

MxA, HuMx1, IFI-78

apoptosis, defense response, signal transduction, IFN-inducible

A00703

interleukin-6

IL-6, B-cell stimulatory factor 2, BSF-2, interferon beta-2, IFNB2, hybridoma growth factor

apoptosis, immune response

A00115

interleukin-1 receptor antagonist

IL-1RA,  ICIL-1RA, IRAP, IL1RN, IL1RAGP130

apoptosis, immune response

A01429

interleukin-4-induced transcription factor Stat6

Stat6, Interleukin-4-induced transcription factor Stat6, IL-4  Stat

immune response, NS5A-regulated, transcription factor

A00332

interleukin-8

IL-8, monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, neutrophil-activating protein 1, NAP-1, lymphocyte-derived neutrophil-activating factor, LYNAP, protein 3-10C, neutrophil-activating factor, NAF, granulocyte chemotactic protein 1, GCP-1, emoctakin

apoptosis, immune response, NS5A-regulated

A00038

macrophage inflammatory protein 1 alpha

GOS19A, GOS19.1, MIP-1 alpha, SCYA3, MIP1A

apoptosis, immune response

A00989

macrophage inflammatory protein-1 beta

MIP-1-beta, small inducible cytokine A4 precursor, T-cell activation protein 2, ACT-2, lymphocyte activation gene-1 protein, LAG-1, G-26 T lymphocyte-secreted protein, SCYA4

apoptosis, immune response

A00194

macrophage stimulating protein

Hepatocyte growth factor-like protein precursor, Macrophage stimulatory protein, MST1, HGFL

cell adhesion and motility, NS5A-regulated

 A02387

manganese-containing superoxide dismutase

SOD2, MnSOD

apoptosis 

A01087

Max Interactor 1

MXI1

apoptosis, transcription factor

A01251

metastasis suppressor Kangai 1

KAI1, CD82 antigen, IA4, SAR2, inducible membrane protein R2
C33 antigen, suppressor of tumorigenicity-6

apoptosis, oncogene, cellular proliferation

A02368

multidrug resistance

MDR1, P-glycoprotein 1, PGY1, ABCB1

apoptosis 

A00171

neuronal apoptosis inhibitory protein

NAIP, BIRC1, Baculoviral IAP repeat-containing protein 1

apoptosis

A02290

NF-kappaB inhibitor alpha

Major histocompatibility complex enhancer-binding protein MAD3, I-kappa-B-alpha, IkappaBalpha, IKB-alpha, NFKBIA, NFKBI, MAD3, IKBA, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, MAD-3

apoptosis, immune response 

A01357

p50 subunit of Nuclear Factor kappa B

p105, NFKB1 

apoptosis, transcription factor, immune response

A00117

p53 tumor suppressor

cellular tumor antigen P53, tumor suppressor p53, phosphoprotein, P53, TP53

transcription factor, cellular proliferation, apoptosis, cell cycle

A00307

Pax5

Pax-5, Paired box protein Pax-5, B-cell specific transcription factor
BSAP, paired box homeotic gene 5, B-cell lineage specific activator protein

transcription factor

A02059

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Mutated in multiple advanced cancers 1, MMAC1, TEP1

apoptosis

A02421

phospholipid transfer protein 

PLTP

metabolism, NS5A-regulated

A01769

prointerleukin-1beta

IL-1 beta,  IL1B, catabolin

apoptosis, immune response

A00263

proliferating cell nucleolar antigen p120

PCNA

cell cycle

A00368

retinoblastoma susceptibility gene 1

RB, RB1

cell cycle, tumor supressor, transcription factor

A00329

selenoprotein P

SELP, SEPP1

detoxification

A02036

serine/threonine kinase 6

Aurora A, aurora2, STK15, serine/threonine kinase 15, STK6, ARK1, BTAK, AIK, IAK1, aurora IPL1-like kinase, Breast-tumor-amplified kinase

hepatocarcinoma-associted

A02109

Signal Transducer and Activator of Transcription 1

STAT1, p91, p84, Signal transducer and activator of transcription 1-alpha/beta,
Transcription factor ISGF-3 components p91/p84

transcription factor, signal transduction, cell cycle, IFN-inducible

A01784

small heterodimer partner

SHP

metabolism, NS5A-regulated

A01567

thioredoxin

ATL-derived factor, ADF, Surface associated sulphydryl protein, SASP, TXN, TRDX, TRX1

apoptosis, detoxification 

A01563

thrombospondin 1

THBS1, TSP 1

cell adhesion, angiogenesis

A00847

thromboxane A2 receptor gene

Prostanoid TP receptor, TXA2-R, TBXA2R

cellular proliferation, signal tansduction, NS5A-regulated

A01333

Sp1

 TSFP1

transcription factor

A02175 

transforming growth factor-beta1

TGFB1, TGF-beta1, TGFB

fibrosis

A01736

tumor necrosis factor alpha

TNF-alpha, cachectin

inflammatory process, IFN-inducible, apoptosis

A00266

tumor necrosis factor receptor-associated factor 1

Epstein-Barr virus-induced protein 6, EBI6, TRAF1

apoptosis

A01864

tyrosine phosphatase

dual specificity protein phosphatase 1, MAP kinase phosphatase-1, MKP-1, protein-tyrosine phosphatase, CL100, dual specificity protein phosphatase HVH1, DUSP1, PTPN10, MKP1, VH1 PRL-1

apoptosis, NS5A-regulated

A00666

urokinase plasminogen activator surface receptor

monocyte activation antigen mo3, cd87 antigen, plaur, mo3

 

cell adhesion and motility, NS5A-regulated

A01242

vascular endothelial growth factor B

 VEGFB, VRF, VEGF related factor

 cellular proliferation, angiogenesis

 A01071

vimentin

 

cell adhesion, NS5A-regulated

A02181

Waf1 kinase inhibitor

cyclin-dependent kinase inhibitor 1, melanoma differentiation associated protein 6, MDA-6, P21, CDK-interacting protein 1, CDKN1A, CDKN1, CIP1, WAF1, MDA6, SDI1, PIC1, CAP20

cellular proliferation, apoptosis, cell cycle

A00359

Wilms tumor 1

WT1, Wilms tumor suppressor 1, GUD, WAGR, WIT-2

cell cycle, tumor supressor

A00745

References

Girard S., Vossman E., Misek D.E., Podevin P., Hanash S., Brechot C., Beretta L. Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses. Hepatology. 2004 Sep;40(3):708-18.

Anders R.A., Yerian L.M., Tretiakova M., Davison J.M., Quigg R.J., Domer P.H., Hoberg J., Hart J. cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis. Am J Pathol. 2003 Mar;162(3):991-1000.

Smith M.W., Yue Z.N., Geiss G.K., Sadovnikova N.Y., Carter V.S., Boix L., Lazaro C.A., Rosenberg G.B., Bumgarner R.E., Fausto N., Bruix J., Katze M.G. Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma. Cancer Res. 2003 Feb 15;63(4):859-64.

Iizuka N., Oka M., Yamada-Okabe H., Mori N., Tamesa T., Okada T., Takemoto N., Tangoku A., Hamada K., Nakayama H., Miyamoto T., Uchimura S., Hamamoto Y. Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. Cancer Res. 2002 Jul 15;62(14):3939-44.

Kim W., Oe Lim S., Kim J.S., Ryu Y.H., Byeon J.Y., Kim H.J., Kim Y.I., Heo J.S., Park Y.M., Jung G. Comparison of proteome between hepatitis B virus- and hepatitis C virus-associated hepatocellular carcinoma. Clin Cancer Res. 2003 Nov 15;9(15):5493-500.

Geiss G.K., Carter V.S., He Y., Kwieciszewski B.K., Holzman T., Korth M.J., Lazaro C.A., Fausto N., Bumgarner R.E., Katze M.G. Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. J Virol. 2003 Jun;77(11):6367-75.

Okabe H., Satoh S., Kato T., Kitahara O., Yanagawa R., Yamaoka Y., Tsunoda T., Furukawa Y., Nakamura Y. Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res. 2001 Mar 1;61(5):2129-37.