Comments: The main calculation parameters are given below.
MULTIPLE ALIGNMENT OF "HMEN_DROME_455 " AND HOMOLOGOUS SEQUENCES.
NUMBER OF SEQUENCES: 372.
ALIGNMENT LENGTH: 74.
AMINO ACID PHYSICO-CHEMICAL CHARACTERISTICS: Isoelectric point (Zimmerman et al., 1968).
REFERENCE: J. Theor. Biol. (1968) v.21, p.170-201.
WEIGHTS: according to Felsenstein(1985),Am.Nat.,125,1-15.
Comments: The variances and means for the integral characteristics are given below.
 Mean(M) and variance(V):
1: QH1        21.68394   40.56061  
2: QH2        26.49128   57.51518  
3: QH1+QH2    48.17522   80.70230  
4: QH1-QH2    -4.80733   115.44930 

Comments: This warning message is shown if Felsenstein(1985) weighting is used.
! WARNING:
! All graphs corresponding to original sample data represent
! contrasts  calculated according to Felsenstein(1985),Am.Nat.,125,1-15. 

============== F(i) values distribution in original sample  ===============
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Comments: Below are given the histograms for the integral characteristic values in  
the original sample. The alignment parameters (sequence number and  length),
type of physicochemical property, means and the  variability in the given characteristic 
are given  in the legend to each  histogram. 









=================== F(i,j) values pairwise scatterplots ===================
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Comments: Below is given a pairwise scatterplot for the mutuual distributuon 
of an integral characteristic pair in the  aligned sequences. 
The alignment parameters (sequence number and  length),
type of physicochemical property, means, the linear correlation coefficient, parameters 
of the linear regression, 95% confidence intervals for the regression coefficients  
are given  in the legend to each  histogram.














========== F(i) dispersion values distribution in random samples ==========
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Comments: Below are given the histograms for the distribution of the sample variations in 
integral characteristics in a set of randomized samples with no dependence among substitutions. 
The legend to each histogram indicates the number of random samples,
variation value in a real sample, variation value expected in the absense of co-ordinated substitutions,
the mean and mean square deviation of the characteristic variance in randomized samples, 
the proportion of randomized samples with Drand>Dorig. Red  arrow variation value in  a real sample.










========== (Dexp/D)=Lambda(i) dispersion ratio values distribution in random samples ==========
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Comments: Histograms for variations in the D_rand/D_orig ratio lambda in a set of 
randomised samples with no dependence among substitutions.  
The legend to each histogram indicates the number of random samples,
variation value in a real sample, variation value expected in the absense 
of co-ordinated substitutions, the mean and mean square deviation of the 
lambda variance in randomized samples, the proportion of randomized 
samples with lambda_rand>lambda_orig. Red  arrow points to the D_rand/D_orig 
value in  a real sample.