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Genes of Lipid Metabolism

Lipid Metabolism Transcription Regulatory Regions Database (LM-TRRD)

Version 3.6 revised January 25, 2003
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Compiler: Ignatieva E.V. e-mail: eignat@bionet.nsc.ru

Annotator:   Proscura A L.

 


Lipid transport and metabolism disorders are the main causes of atherosclerosis and coronary heart disease. LM-TRRD database contains information about genes the products of which take part in lipid metabolism. This group includes the genes of apolipoproteins and serum amyloid proteins which participate in the transport of lipids, genes of cell surface receptors, and enzymes essential to the lipid metabolism. For example, among them there are genes encoding proteins participating in cholesterol biosinthesis and beta-oxidation pathway. Genes encoding transcription factors, which regulate the genes mentioned above, are also included into this group.

LM-TRRD Publications

    Genes classified  by functional role of encoded proteins:

    Genes classified  by subsystems:

 

   Genes involved in lipid metabolism in 
      liver cells 
      in adipocyte 
      in blood


   Genes involved in 
regulation of 
     intracellular cholesterol level
     body weight

 


Genes encoding proteins taking part in lipid transport

Ac.number

Gene

Organism

A02041 acyl-CoA-binding protein gene Homo sapiens
A02042 acyl-CoA-binding protein gene Mus musculus
A02043 acyl-CoA-binding protein gene Rattus norvegicus

A01981

acyl-CoA:monoacylglycerol acyltransferase Mus musculus

A00061

adipocyte P2 gene Mus musculus

A01243

apolipoprotein A-I gene Gallus gallus

A00264

apolipoprotein A-I gene Homo sapiens

A00293

apolipoprotein A-I gene Mus musculus

A00349

apolipoprotein A-I gene Oryctolagus cuniculus

A00158

apolipoprotein A-I gene Rattus norvegicus

A00148

apolipoprotein A-II gene Homo sapiens

A00294

apolipoprotein A-IV gene Homo sapiens

A00295

apolipoprotein A-IV gene Mus musculus

A00296

apolipoprotein A-IV gene Rattus norvegicus

A00149

apolipoprotein B gene Homo sapiens

A01300

apolipoprotein B gene Rattus norvegicus
A01436 apolipoprotein C-I gene Homo sapiens
A01434 apolipoprotein C-I gene Mus musculus

A00350

apolipoprotein C-II gene Homo sapiens

A00196

apolipoprotein C-III gene Homo sapiens

A00159

apolipoprotein C-III gene Rattus norvegicus

A00150

apolipoprotein D gene Homo sapiens

A00151

apolipoprotein E gene Homo sapiens

A01435

apolipoprotein E gene Mus musculus

A00146

apolipoprotein VLDLII gene Gallus gallus

A00147

apolipoprotein(a) gene Homo sapiens
A01560 ATP-binding cassette A 1 Homo sapiens
A01559 ATP-binding cassette, sub-family G, member 1 Homo sapiens

A01785

bile salt export pump gene Homo sapiens

A00435

cellular retinol-binding protein II gene Mus musculus

A00420

cellular retinol-binding protein II gene Rattus norvegicus

A00841

cholesteryl ester transfer protein gene Homo sapiens
A01491 cytosolic acyl-CoA thioesterase gene Mus musculus
A01437 fatty acid transport protein gene Mus musculus

A01770

Intestinal bile acid-binding protein gene Homo sapiens

A00416

intestinal fatty acid binding protein gene Rattus norvegicus

A01771

Ileal Bile Acid-binding protein gene Mus musculus

A01979

Ileal Bile Acid-binding protein gene Rattus norvegicus

A00911

microsomal triglyceride transfer protein gene Homo sapiens

A00912

microsomal triglyceride transfer protein gene Cricetulus griseus

A01492

mitochondrial acyl-CoA thioesterase gene Mus musculus

A01769

phospholipid transfer protein gene Homo sapiens

A01804

phospholipid transfer protein gene Mus musculus

A00251

serum amyloid A gene Oryctolagus cuniculus

A00166

serum amyloid A1 gene Rattus norvegicus

A00165

serum amyloid A3 gene Mus musculus

A00213

serum amyloid Ag9 gene Homo sapiens

 

Genes encoding enzymes

Ac.number

Gene

Organism

A01919

1-acylglycerol-3-phosphate O-acyltransferase 2 Homo sapiens

A00888

25-hydroxyvitamin D3-24-hydroxylase gene Homo sapiens

A00887

25-hydroxyvitamin D3-24-hydroxylase gene Rattus norvegicus

A00889

25-hydroxyvitamin-D3-1alpha-hydroxylase gene Mus musculus

A00258

acetyl-CoA carboxylase gene Rattus rattus

A00434

acyl CoA oxidase gene Homo sapiens

A00419

acyl CoA oxidase gene Rattus norvegicus

A01513

acetyl-CoA synthetase gene Mus musculus

A00412

acyl-coenzyme A synthetase Rattus norvegicus
A01558 ATP citrate-lyase gene Homo sapiens
A01557 ATP citrate-lyase gene Rattus norvegicus

A02044

Carnitine O-palmitoyltransferase 2, mitochondrial gene Homo sapiens

A02018

Cholesterol 7-alpha-monooxygenase gene Cricetulus griseus

A00410

cholesterol 7alpha-hydroxylase gene (CYP7 gene) Homo sapiens

A01973

Cholesterol 7-alpha-hydroxylase gene Mus musculus

A00411

cholesterol 7alpha-hydroxylase gene (CYP7 gene) Rattus norvegicus
A01620 cyclooxygenase 1 gene Homo sapiens
A01619 cyclooxygenase 2 gene Bos taurus

A00882

cyclooxygenase 2 gene Homo sapiens

A00883

cyclooxygenase 2 gene Mus musculus

A00914

cyclooxygenase 2 gene Rattus norvegicus

A02021

Cytochrome P450 2H1 gene Gallus gallus

A00640

cytochrome P-450 4A6 gene (CYP4A6 gene) Oryctolagus cuniculus

A01793

cytochrome P450 8B1 gene Homo sapiens

A01768

cytochrome P450 8B1 gene Mus musculus

A01664

cytosolic phospholipase A2 gene Rattus norvegicus

A01786

dehydroepiandrosterone sulfotransferase gene Rattus norvegicus

A01920

Diacylglycerol O-acyltransferase 1 gene Homo sapiens

A01921

Diacylglycerol O-acyltransferase 1 gene Mus musculus

A00408

farnesyl diphosphate synthase gene Rattus norvegicus

A01074

fatty acid synthase gene Homo sapiens

A01514

fatty acid synthase gene Mus musculus

A00413

fatty acid synthase gene Rattus norvegicus

A01156

hepatic neutral cholesterol ester hydrolase gene Rattus norvegicus

A00091

hepatic triglyceride lipase gene Homo sapiens

A00454

HMG-CoA reductase gene Chinese hamster

A00436

HMG-CoA reductase gene Homo sapiens

A01075

HMG-CoA reductase gene Rattus norvegicus

A00415

HMG-CoA synthase gene Mesocricetus auratus

A00254

Hydratase-dehydrogenase gene Rattus norvegicus

A02019

Lecithin-cholesterol acyltransferase gene

A02020

lecithin-cholesterol acyltransferase gene Rattus norvegicus

A00421

lipoprotein lipase gene Homo sapiens

A00614

lipoprotein lipase gene Mus musculus

A00422

malic enzyme gene Rattus norvegicus

A00418

medium-chain acyl coenzyme A dehydrogenase gene Homo sapiens

A00613

mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase gene Rattus norvegicus

A00414

mitochondrial glycerol-3-phosphate acyltransferase gene Mus musculus
A01493 peroxisomal acyl-CoA thioesterase a gene Mus musculus
A01494 peroxisomal acyl-CoA thioesterase b gene Mus musculus
A01621 phospholipase A2 gene Homo sapiens

A01622

phospholipase C-gamma-1 gene Homo sapiens

A01676

phospholipase C-gamma 1 gene Rattus norvegicus

A00400

squalene synthase gene Homo sapiens

A01515

stearoyl-CoA desaturase 1 Mus musculus

A01766

sterol-12 alpha-hydroxylase gene Rattus norvegicus

A01755

triosephosphate isomerase gene Homo sapiens

A01675

type II-secreted phospholipase A2 gene Rattus norvegicus

Genes encoding cell surface receptors

Ac.number

Genes

Organism

A00417

alpha2-macroglobulin receptor/lipoprotein receptor-related protein gene Homo sapiens

A01841

growth hormone secretagogue receptor type 1 gene Homo sapiens

A01839

growth hormone secretagogue receptor type 1 gene Rattus norvegicus

A00407

LDL receptor gene Homo sapiens

A00500

macrophage scavenger receptor gene Homo sapiens

A01274

neuropeptide Y-Y1 receptor gene Homo sapiens

A01723

neuropeptide Y-1 receptor gene Mus musculus

A01850

scavenger receptor class B type I gene Homo sapiens

A02022

scavenger receptor class B type I gene Rattus norvegicus

Genes encoding hormones and neuropeptides

Ac.number

Genes

Organism

A01842

ghrelin gene Homo sapiens

A01843

ghrelin gene Mus musculus

A01840

ghrelin gene Rattus norvegicus

A00501

leptin gene (obese gene) Mus musculus

A00502

leptin gene (obese gene) Homo sapiens

A01154

neuropeptide Y gene Homo sapiens

A01255

neuropeptide Y gene Rattus norvegicus

Genes encoding transcription factors

Ac.number

Genes

Organism

A00109

CCAAT/enhancer binding protein alpha gene Mus musculus

A00409

CCAAT/enhancer binding protein alpha gene Rattus norvegicus

A00376

CCAAT/enhancer binding protein alpha gene Homo sapiens

A00305

early growth response factor gene Mus musculus

A01974

farnesoid X-activated receptor Mus musculus

A01352

hepatocyte nuclear factor-1 beta gene Mus musculus

A00382

hepatocyte nuclear factor 1 gene Xenopus laevis

A00383

hepatocyte nuclear factor 3 beta gene Rattus norvegicus

A00384

hepatocyte nuclear factor 4 gene Mus musculus

A00161

hepatocyte nuclear factor-1 gene Rattus norvegicus

A00479

hepatocyte nuclear factor-3alpha gene Rattus norvegicus

A00481

hepatocyte nucler factor 3 gamma gene Mus musculus

A01794

liver X receptor alpha gene Homo sapiens

A01811

liver X receptor alpha gene Mus musculus

A01812

liver X receptor beta gene Mus musculus

A01754

peroxisome proliferator activated receptor alpha Mus musculus

A01379

peroxisome proliferator activated receptor gamma gene Homo sapiens

A01381

peroxisome proliferator activated receptor gamma gene Mus musculus

A01135

retinoic acid receptor alpha gene Homo sapiens

A00212

retinoic acid receptor beta gene Homo sapiens

A01765

retinoid X receptor gamma gene Mus musculus

A01099

retinoic acid receptor beta gene Mus musculus

A01083

retinoid X receptor gamma 2 gene Homo sapiens

A01433

Rev-erb alpha gene Homo sapiens

A00612

sterol regulatory element-binding protein-2 gene Homo sapiens

A00615

sterol regulatory element-binding protein-1 gene Mus musculus

A02023

Sterol regulatory element binding protein-1 gene Rattus norvegicus

Other genes

Ac.number

Genes

Organism

A01857

adiponectin precursor gene Mus musculus

A01856 

adipose most abundant gene transcript 1 gene Homo sapiens

A00596

Alzheimer's disease amyloid A4 precursor protein gene Homo sapiens

A01753

aquaporin adipose gene Mus musculus

A01972

Bile salt export pump gene Mus musculus

A01977

bile salt export pump Rattus norvegicus

A00611

caveolin gene Homo sapiens

A02032

caveolin-1 gene Mus musculus

A02031

caveolin-1 gene Rattus norvegicus

A01752

c-Cbl-associating protein gene Mus musculus

A00029

insulin-responsive glucose transporter Mus musculus

A00916

mitochondrial uncoupling protein gene Mus musculus

A00639

S14 gene Rattus norvegicus

A01980

small heterodimer partner gene Rattus norvegicus

A00915

uncoupling protein-1 gene Rattus norvegicus

LM-TRRD Publications

 Ignat'eva E.V., Merkulova T.I., Vishnevskii O.V., Kel' A.E.

Regulation of Transcription of lipid metabolism genes: description in the TRDD database.

Mol Biol (Mosk) 1997 Jul;31(4):575-591

 

E.V. Ignatieva

The Lipid Metabolism Transcription Regulatory Regions Database (LM-TRRD): Transcription Regulation of Lipid Metabolism Genes.

Proceedings of the First International Conference on Bioinformatics of Genome Regulation and Structure. 1998. BGRS’98. Novosibirsk - Altai Mountains, Russia, August 24-31, 1998. P.45-49.


Bibliographic assistance: Lokhova I.V.
WebMaster: Grigorovich D.A.

 


 

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