ERYTHROID-SPECIFIC REGULATED GENES

is developed by Podkolodnaya O.A., Stepanenko I.L.

Erythropoiesis is a complex multistage process comprising proliferation, differentiation, and maturation of erythroid cells proceeds in different tissue environment at different stages of ontogenesis. Analysis of numerous available experimental data on transcription regulation of erythroid-specific genes required their unification and systematization. For this aim, we created a database of erythroid-specific regulated genes (ESGR-TRRD) where the data on structure-function organization of the regulatory regions of these genes and the peculiarities of their functioning are being accumulated in TRRD format.

Globins Heme Biosynthetic Pathway Enzymes Enzymes Transcription Factors Cell Surface Antigens and Other Locus Control Regions

Globins

*Gene name*	*Organism*	*TRRD AC*	*Regulatory Units*	*Binding sites*	*EMBL AC*
AlphaA-globin	Chicken	A00003	2	13	X56801
Alpha-D-globin	Chicken	A00428	1	3	V00411
Pi-globin	Chicken	A00373	1	7	V00408
BetaA-globin	Chicken	A00442	2	24	V00409
BetaH-globin	Chicken	A00423	1	7	X13142
Rho-globin	Chicken	A00401	4	8	L17432
Epsilon globin	Chicken	A00983	1	6	K00824
Alpha1-globin	Human	A00427	2	13	J00153
Alpha2-globin	Human	A00425	2	8	J00153
Zeta2-globin	Human	A00330	2	9	J00182
Beta-globin	Human	A00334	4	21	U01317
Delta-globin	Human	A00424	1	2	U01317
Agamma globin	Human	A00297	3	32	M91037
Ggamma-globin	Human	A00338	1	5	V00517
Epsilon-globin	Human	A00323	3	8	V00508
Alpha-globin	Rabbit	A00309	5	12	M74142
Alpha1-globin	Mouse	A00004	2	15	J00410
Zeta-globin	Mouse	A00455	1	2	X62302
Beta major -globin	Mouse	A00014	5	12	M18646

Heme Biosynthetic Pathway Enzymes

*Gene name*	*Organism*	*TRRD AC*	*Regulatory Units*	*Binding sites*	*EMBL AC*
ALAS-E	Chicken	A00651	1	8	S69605
ALAS-E	Human	A00654	2	8	AF068624
Porphobilinogen deaminase	Human	A00380	2	10	M18800 M95623
Porphobilinogen deaminase	Mouse	A00381	4	12	M28663
Delta aminolevulinate dehydratase	Human	A00462	2	-	X64467
Ferrochelatase	Human	A00509	3	8	L36178
CPO	Human	A00626	1	2	Z34531

Enzymes

*Gene name*	*Organism*	*TRRD AC*	*Regulatory Units*	*Binding sites*	*EMBL AC*
L-type pyruvate kinase gene	Rat	A00138	3	25	X85791
Glutathion peroxidase	Mouse	A00463	2	11	X03920
15-lipoxygenase	Rabbit	A00523	2	12	X90860
Carbonic Anhydrase I	Mouse	A00506	2	3	M28196 M28197
Carbonic Anhydrase I	Human	A00507	2	8	M33987 X05014

Transcription Factors

*Gene name*	*Organism*	*TRRD AC*	*Regulatory Units*	*Binding sites*	*EMBL AC*
HOXB2	Human	A00443	1	2	X78978
GATA1	Mouse	A00327	2	3	X56854
GATA1	Rat	A00948	2	1	AB003114
GATA1	Zebrafish	A00944	4	4	AF080621
GATA1	Chicken	A00325	1	13	M59937
TAL1	Human	A00405	1	6	S53698
TAL1	Mouse	A00406	2	7	U01530
EKLF	Mouse	A00319	1	5	AF033102
RBTN2	Human	A00512	2	2	X61118

Cell Surface Antigens and Other

*Gene name*	*Organism*	*TRRD AC*	*Regulatory Units*	*Binding sites*	*EMBL AC*
Erythropoietin receptor	Mouse	A00324	3	4	M38133
Erythropoietin receptor	Human	A00453	4	11	M77244
Erythropoietin	Human	A00292	2	5	M11319
Erythropoietin	Mouse	A00452	1	2	M12930
Glycophorin a	Mouse	A00632	1	6	D83709 M26385
Glycophorin A	Human	A00320	1	-	M24123
Glycophorin B	Human	A00321	1	8	M57233
Glycophorin C	Human	A00322	1	1	X14242
Glycoprotein D	Human	A00508	1	2	X85785
ferritin heavy chain	Mouse	A00511	4	9	M85257
transferrin receptor	Human	A00505	1	4	X05339
Apoferritin L	Human	A00897	2	2	X03742 Y09188
Ferritin, heavy chain	Human	A00879	2	2	M14211
histone H5	Chicken	A00099	4	19	J00870 X00169

Locus Control Regions

*Gene name*	*Organism*	*TRRD AC*	*Regulatory Units*	*Binding sites*	*EMBL AC*
Alpha locus control region (HS-40)	Human	A00328	1	10	S49899
beta locus control region (beta -LCR)	Human	A00075	2	15	U01317
beta locus control region (beta -LCR)	Chicken	A00589	3	13	U78775
Glycophorin a	Mouse	A00632	1	6	D83709 M26385