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Heat Shock-Induced Genes (HS-TRRD database)

Irina L. Stepanenko  e-mail: stepan@bionet.nsc.ru

The heat shock response, the increased transcription of a set of genes in response to heat or other toxic agent exposure is a highly conserved biological response, occurring in all organisms.  The response is mediated by heat shock transcription factor (HSF), which is present in a monomeric, non-DNA binding form in unstressed cells and is activated by stress to an trimeric form which can bind to promoters of heat shock genes. The heat shock element, cis-element for activated heat shock factor, consists of inverted repeats of the sequence nGAAn, where n can be an arbitrary nucleotide.

The heat shock proteins (HSPs) are classified into different families on the basis of molecular mass and distinguished according to their ability to induce: heat shock cognate (hsc) are constantly synthesized, whereas others are expressed only following stress.  Heat shock proteins interact with numerous other proteins and their main function is to control  the accurate folding and translocation of polypeptides at the different cellular compartments.

HSP70 multigene family
A00102 human, Homo sapiens heat shock protein 70 HSP70.1, HSP70-1/HSP70-2, HSPA1A,  HSPA1,  HSPA1B
A00761 human, Homo sapiens heat shock protein 70B  HSP70B, HSP70-B-prime
A00728 rat, Rattus norvegicus heat shock protein 70 HSP70-1, HSP70-2
A00759 chicken, Gallus gallus heat shock protein 70  HSP70
A00552 frog, Xenopus laevis heat shock protein 70A  HSP70A
A00553 frog, Xenopus laevis heat shock protein 70B  HSP70B
A00033 fruit fly, Drosophila melanogaster heat shock protein 70 HSP70-87A7, HSP70AB, HSP70A
A00572 hydra, Hydra magnipapillata heat shock protein 70 HSP70.1
A00573 hydra, Hydra oligactis heat shock protein 70  HSP70
A00592 sea urchin, Paracentrotus lividus heat shock protein 70.II HSP70II
A00598 mouse, Mus musculus heat shock protein 70.3 HSP70.3, HSP70-3, HSP70A1
A00597 mouse, Mus musculus heat shock protein 70.1 HSP70-1/HSP70-2, HSPA1, HSP70A1,  HSP70-1, HCP70.1
A01205 marine sponge, Geodia cydonium heat shock protein 70 HSP70, HSP73
A00604 yeast, Saccharomyces cerevisiae SSA1 heat shock protein YG100, SSA1, YAL005C
A00763 yeast, Saccharomyces cerevisiae SSA3 heat shock protein SSA3, HSP70, YBL075C, YBL0610, YBL06.07
A00834 fission yeast, Schizosaccharomyces pombe mitochondrial HSP70 SSP1, SPAC664.11
A00576 human, Homo sapiens glucose-regulated protein 78 GRP 78, IMMUNOGLOBULIN  HEAVY CHAIN BINDING PROTEIN, BIP, HSPA5
A00660 rat, Rattus norvegicus glucose-regulated protein 78 GRP 78, IMMUNOGLOBULIN HEAVY CHAIN BINDING PROTEIN, BIP, STEROIDOGENESIS-ACTIVATOR POLYPEPTIDE, HSPA5
A01204 marine sponge, Suberites domuncula glucose- regulated protein 78 GRP78
A00590 rat, Rattus norvegicus heat shock protein 75 HSP75, 75 KDA GLUCOSE REGULATED PROTEIN, GRP 75, PEPTIDE-BINDING PROTEIN 74, PBP74, MTHSP70, MORTALIN, HSPA9, pp75 
A00838 rat, Rattus norvegicus heat shock cognate 73 HSC73, HSPA, HSC70
A00566 human, Homo sapiens heat shock protein 75 HSP75
A00571 human, Homo sapiens heat shock cognate 70 HSPA8,  HSPA10,  HSC70, HSP73
A00820 mouse, Mus musculus heat shock cognate 72 HSPA8, HSC70, HSC73
A01203 marine sponge, Suberites domuncula heat shock cognate 70 HSC70, HSP73
A00600 mouse, Mus musculus heat shock protein 70 testis-specific HSC70T

HSP100 multigene family
A00762 mouse, Mus musculus heat shock protein 110 HSP110, OSMOTIC STRESS PROTEIN 94, OSP94, APG1
A00830 mouse, Mus musculus heat shock protein 105 HSP105, HSP110, HSP-E7I
A00821 yeast, Saccharomyces cerevisiae heat shock protein 150 HSP150, PIR2
A00836 yeast, Saccharomyces cerevisiae YG101 heat shock cognate SSB2, YNL209W, N1333

HSP90 multigene family
A00180 human, Homo sapiens heat shock protein 90 beta HSP90B, HSP 84, HSP 90, HSPCB, HSPC2
A00562 human, Homo sapiens heat shock protein 89 alpha HSP89A
A00570 chicken, Gallus gallus heat shock protein 90 beta HSP 90-BETA, HEAT SHOCK COGNATE PROTEIN,  HSPCB
A01169 chicken, Gallus gallus heat shock protein 90 alpha HSP89, HSP90A
A00724 human, Homo sapiens heat shock protein 86 HSP86, HSPCA, HSPC1, HSP90A
A00599 mouse, Mus musculus heat shock protein 86 HSP86, HSP86-1, HSP 90-ALPHA, TUMOR SPECIFIC TRANSPLANTATION 86 KDA ANTIGEN, TSTA, HSPCA
A00807 mouse, Mus musculus heat shock protein 84 HSP84, HSP 90-BETA, TUMOR SPECIFIC   TRANSPLANTATION 84 KDA ANTIGEN, TSTA
A00818 fruit fly, Drosophila melanogaster heat shock protein 83 HSP83, HSP82,  CG1242
A00607 yeast, Saccharomyces cerevisiae heat shock protein 82 HSP82, HSP90, YPL240C
A00609 mouse-ear cress, Arabidopsis thaliana heat shock protein 81.1 HSP81-1, HSP83
A01122 maize, Zea mays heat shock protein 82 HSP82
A00868 fungus, Candida albicans heat shock protein 90 HSP90

HSP60 genes
A01139 lamblia, Giardia intestinalis heat shock protein 60 HSP60

HSP40 genes
A00726 mouse, Mus musculus heat shock protein 47 HSP47, COLLAGEN-BINDING PROTEIN 1, SERINE PROTEASE INHIBITOR J6, SERPINH1, CBP1

Small heat shock protein genes
A00516 human, Homo sapiens heat shock protein 27 HSP27, HSPB1, HSP28, SRP27
A00663 rat, Rattus norvegicus heat shock protein 27 HSP27, HSPB1
A00605 mouse, Mus musculus alpha B crystallin CRYAB, CRYA2, P23
A00595 fruit fly, Drosophila melanogaster heat shock protein 27 HSP27, CG4466
A00594 fruit fly, Drosophila melanogaster heat shock protein 26 HSP26, CG4183
A00723 fruit fly, Drosophila melanogaster heat shock protein 22 HSP22, CG4460
A00837 fungi, Aspergillus nidulans heat shock protein 30 kDa HSP30
A00869 frog, Xenopus laevis heat shock protein 30 C HSP30 C
A01114 maize, Zea mays 18 kDa heat shock protein 3 HSP18
A01115 maize, Zea mays 18 kDa heat shock protein 1 HSP18, HSP18-1
A00527 soybean, Glycine max heat shock protein 18.5-C HSP 18.5-C
A00528 soybean, Glycine max heat shock protein 17.9-D HSP 17.9-D
A00717 soybean, Glycine max heat shock protein 17.5-E HSP 17.5-E
A00825 soybean, Glycine max heat shock protein 17.5-L HSP 17.5-L
A00826 soybean, Glycine max heat shock protein 17.5-M HSP 17.5-M
A00973 soybean, Glycine max heat shock protein 17.3-B HSP 17.3-B
A00864 sunflower, Helianthus annuus 10 kDa Late embryogenesis abundant protein DS10
A00866 sunflower, Helianthus annuus heat shock protein 17.6 HSP 17.6 

Stress-induced genes
A00727 mouse, Mus musculus octeonectin SPARC, ON, SECRETED PROTEIN ACIDIC AND RICH IN CYSTEINE,  BASEMENT MEMBRANE PROTEIN BM-40
A00059 rat, Rattus norvegicus serum albumin  ALB
A00563 human, Homo sapiens calreticulin CALR, CRP55, CALREGULIN, HACBP, ERP60,  AUTOANTIGEN RO/SS-A, CRTC  
A00551 human, Homo sapiens heme oxygenase HO-1, HMOX1, HO1, HO
A00569 rat, Rattus norvegicus heme oxygenase HO-1, HSP32, HMOX1
A00725 mouse, Mus musculus heme oxygenase HO-1, P32,  HMOX1
A00666 human, Homo sapiens tyrosine phoshatase CL100, MAP KINASE PHOSPHATASE-1, MKP-1,MKP1,    DUSP1, PTPN10,  VH1 
A00898 frog, Xenopus laevis pyruvate kinase HSP62, CYTOSOLIC THYROID HORMONE BINDING PROTEIN, CTHBP
A00171 human, Homo sapiens multidrug resistance 1 MDR1, P-GLYCOPROTEIN 1, PGY1, ABCB1
A00172 mouse, Mus musculus multidrug resistance 1 MDR1, MDR1B, P-GLYCOPROTEIN 1, PGY1, PGY1-1,  ABCB1  
A00662 rat, Rattus norvegicus multidrug resistance 1B MDR1B, MDR1, P-GLYCOPROTEIN 1, PGY1, PGY1-1,  ABCB1   
A00564 human, Homo sapiens Cu/Zn superoxide dismutase SOD1
A01183 rat, Rattus norvegicus Cu/Zn superoxide dismutase SOD1
A00596 human, Homo sapiens Alzheimer's disease amyloid A4 precursor AAP, PROTEASE NEXIN-II, PN-II,  APPI, A4, CVAP, AD1, APP, PAD, AD-AP
A00777 yeast, Saccharomyces cerevisiae metallothionein CUP1, CU-MT, COPPER CHELATIN,   MTH1, YHR053C, YHR055C
A00817 chicken, Gallus gallus ubiquitin  UB
A00881 fruit fly, Drosophila melanogaster hsr-omega 93D, ER3, HSRW, HEAT SHOCK RNA OMEGA
A00884 quail, Coturnix coturnix clusterin  APOJ, T64
A00885 human, Homo sapiens clusterin APO-J, COMPLEMENT-ASSOCIATED PROTEIN SP-40,40, COMPLEMENT CYTOLYSIS INHIBITOR, CLI,  NA1,  NA2, APOLIPOPROTEIN  J,    TRPM-2, CLU  
A00953 rat, Rattus norvegicus p67-kDa glycoprotein P67, METHIONINE AMINOPEPTIDASE 2, METAP 2, PEPTIDASE M 2, INITIATION FACTOR 2 ASSOCIATED 67 KDA GLYCOPROTEIN, P67EIF2, MNPEP
A01066 human, Homo sapiens DNA topoisomerase II alpha  TOP2A, TOP2
A01164 mouse-ear cress, Arabidopsis thaliana ascorbate peroxidase cytosolic form APX1, F24B9.2, AP

Heat shock transcription factor genes
A00574 human, Homo sapiens heat shock factor 1  HSF1, hHSF1, HSTF1
A00575 human, Homo sapiens heat shock factor 2  HSF2, hHSF2, HSTF2
A00664 mouse, Mus musculus heat shock factor 1  HSF1, mHSF1, HSTF1
A00667 mouse, Mus musculus heat shock factor 2 HSF2, mHSF2, HSTF2
A00547 frog, Xenopus laevis heat shock factor1 HSF1, HSF
A00661 human, Homo sapiens heat shock factor 4 HSF4, hHSF4 
A01076 mouse-ear cress, Arabidopsis thaliana heat shock factor 4 HSF4, HSTF 4, AT4G36990, C7A10.370

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This work was supported by the grant INTAS-96-1787