Redox-sensitive Genes (ROS-TRRD database)
Irina L. Stepanenko e-mail: stepan@bionet.nsc.ru
Reactive oxygen species (ROS) including superoxide radical (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (-OH) are formed in various metabolic processes. ROS are involved in intracellular signal transduction and expression regulation of the genes determining the anti-inflammatory response, cell growth, proliferation and differentiation, apoptosis, and stress response. The expression of redox-sensitive genes is regulated by redox (reduction-oxidation) status of a cell.
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TRRD gene name |
Species |
Gene name synonym |
TRRD AC |
|
aldolase A |
Homo sapiens |
muscle-type aldolase, lung cancer ANTIGEN NY-LU-1, ALDOA, ALDA |
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aldolase A |
Rattus norvegicus |
fructose-bisphosphate aldolase A, muscle-type aldolase, ALDOA |
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aldolase B |
Rattus norvegicus |
ADB, ALDOB |
|
|
apoferritin L |
Homo sapiens |
FTL, ferritin light chain, ferritin L subunit |
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|
apurinic/apyrimidinic endonuclease |
Homo sapiens |
REF1, DNA -- (apurinic or apyrimidinic site) lyase, apendonuclease 1, APEX nuclease, APEN, APEX, APE, HAP1, APX |
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|
ascorbate peroxidase cytosolic form |
Arabidopsis thaliana |
APX1, F24B9.2, AP |
|
|
c-fos protooncogene |
Homo sapiens |
p55-c-fos proto-oncogene protein, cellular oncogene c-fos, G0S7 protein, FOS |
|
|
c-fos protooncogene |
Mus musculus |
p55-c-fos proto-oncogene protein, cellular oncogene c-fos, FOS |
|
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c-jun protooncogene |
Homo sapiens |
transcription factor AP-1, P39, G0S7, JUN |
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|
c-myc protooncogene |
c-myc protooncogene |
C-MYC, MYC |
|
|
c-myc protooncogene |
Mus musculus |
C-MYC, MYC |
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Cu/Zn superoxide dismutase |
Rattus norvegicus |
SOD1 |
|
|
Cu/Zn superoxide dismutase |
Homo sapiens |
SOD1 |
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cyclooxygenase 2 |
Homo sapiens |
COX-2, prostaglandin G/H synthase 2 precursor, prostaglandin-endoperoxide synthase 2, prostaglandin H2, synthase 2, PGH synthase 2, PGHS-2, PHS II, PTGS2, PES-2 |
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cyclooxygenase 2 |
Mus musculus |
COX-2, prostaglandin G/H synthase 2 precursor, prostaglandin-endoperoxide synthase 2, prostaglandin h2, synthase 2, PGH synthase 2, PGHS-2, PHS II, glucocorticoid-regulated inflammatory cyclooxygenase, GRIPGHS, TIS10 protein, macrophage activation-associated marker protein P71/73, PES-2, PTGS2, COX2, TIS10, PGHS-B |
|
|
cyclooxygenase 2 |
Rattus norvegicus |
COX-2, prostaglandin G/H synthase 2 precursor, prostaglandin-endoperoxide synthase 2, prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, PHS II, PTGS2, COX2 |
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|
cytochrome b558 heavy chain |
Homo sapiens |
P22 phagocyte b-cytochrome neutrophil cytochrome B, 91 KDA polypeptide, CGD91-PHOX, GP91-PHOX, heme binding membrane glycoprotein, GP91PHOX, superoxide-generating NADPH oxidase heavy chain subunit |
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|
cytochrome c oxidase VIIa liver isoform |
Bos taurus |
cytochrome c oxidase polypeptide VIIA-liver/heart, mitochondrial precursor, cytochrome c oxidase subunit VIIA-L, VIIIC, COX7A2, COX7AL |
|
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cytochrome P-450 4A6 |
Oryctolagus cuniculus |
CYPIVA6, lauric acid omega-hydroxylase, P450-KA-1, CYP4A6 |
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|
cytochrome P450 family I A1 |
Mus musculus |
CYPIA1, P450-P1, CYP1A1, CYP1A-1 |
|
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cytosolic glutathione peroxidase |
Mus musculus |
GSHPX-1, cellular glutathione peroxidase, GPX1 |
|
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endothelin 1 |
Homo sapiens |
EDN1, ET-1 |
|
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endothelial leukocyte adhesion molecule 1 |
Homo sapiens |
E-selectin, ELAM-1, leukocyte-endothelial cell adhesion molecule 2, LECAM2, CD62E |
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erythropoietin |
Homo sapiens |
EPO |
|
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ferritin, heavy chain |
Homo sapiens |
ferritin H subunit, FTH1, FTH, FTHL6 |
|
|
gamma-glutamylcysteine synthetase light subunit |
Homo sapiens |
glutamate--cysteine ligase regulatory subunit, gamma-glutamylcysteine synthetase, gamma-ECS, GCS light chain, glutamate--cysteine ligase modifier subunit, GCLM, GLCLR |
|
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glucose-regulated protein 78 |
Rattus norvegicus |
GRP 78, immunoglobulin heavy chain binding protein, BiP, steroidogenesis-activator polypeptide, HSPA5 |
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glutathione S-transferase 103-35 |
Nicotiana tabacum |
||
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glutathione S-transferase A2 |
Rattus norvegicus |
glutathione S-transferase YA, ligandin chain 1 |
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glutathione S-transferase Ya subunit |
Homo sapiens |
GSTA1, GSTYA, GSTA |
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glutathione S-transferase Ya subunit |
Mus musculus |
GSTA1, GSTYA, GSTA |
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glutathione-S-transferase |
Dianthus caryophyllus |
GST class-zeta, GST1, CARSR8 |
|
|
glutathione transferase P |
Homo sapiens |
GST class-PI, GSTP1-1, GSTP1, GST3 |
|
|
glutathione transferase P |
Rattus norvegicus |
GST class-PI |
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granulocyte/macrophage colony stimulating factor |
Mus musculus |
GM-CSF, colony-stimulating factor, CSF, CSF2, CSFGM |
|
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granulocyte/macrophage colony stimulating factor |
Homo sapiens |
GM-CSF, colony-stimulating factor, CSF, sargramostim, molgramostin, CSF2, GMCSF |
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growth arrest and DNA damage-inducible |
Cricetulus longicaudatus |
GADD153, DNA-damage inducible transcript 3, DDIT3, C/EBP-homologous protein, CHOP, TLS-CHOP |
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heat shock protein 27 |
Homo sapiens |
HSP27, HSPB1, HSP28, SRP27 |
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heat shock protein 70 |
Homo sapiens |
HSP70.1, HSP70-1/HSP70-2, HSPA1A, HSPA1, HSPA1B |
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heme oxygenase 1 |
Mus musculus |
HO-1, P32, haem oxygenase, HMOX1 |
|
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heme oxygenase 1 |
Rattus norvegicus |
HO-1, HSP32, HMOX1 |
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inducible nitric oxide synthase |
Rattus norvegicus |
NOS, TYPE II inducible NOS, INOS, NOS2 |
|
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inducible nitric oxide synthase |
Gallus gallus |
NO synthase inducible form, macrophage nitric-oxide synthase, nitric-oxide synthase type 2, type II NOS |
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intercellular adhesion molecule-1 |
Homo sapiens |
major group rhinovirus receptor, CD54, ICAM1 |
|
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intercellular adhesion molecule-1 |
Mus musculus |
ICAM1, ICAM-1, MALA-2 |
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interleukin-1beta |
Mus musculus |
IL-1 beta |
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interleukin 6 |
Homo sapiens |
IL-6, B-cell stimulatory factor 2, BSF-2, interferon beta-2, IFNB2, hybridoma growth factor |
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|
interleukin-8 |
Homo sapiens |
IL-8, monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, neutrophil-activating protein 1, NAP-1, lymphocyte-derived neutrophil-activating factor, LYNAP, protein 3-10C, neutrophil-activating factor, NAF, granulocyte chemotactic protein 1, GCP-1, emoctakin |
|
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macrophage inflammatory protein 1 alpha |
Mus musculus |
small inducible cytokine a3 precursor, MIP-1-ALPHA, SCI, TY-5, SIS-alpha, heparin-binding chemotaxis protein, SCYA3, MIP1A |
|
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macrophage inflammatory protein 1 alpha |
Homo sapiens |
GOS19A, GOS19.1, MIP-1 alpha, SCYA3, MIP1A |
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macrophage inflammatory protein-1 beta |
Homo sapiens |
MIP-1-beta, small inducible cytokine A4 precursor, T-cell activation protein 2, ACT-2, lymphocyte activation gene-1 protein, LAG-1, G-26 T lymphocyte-secreted protein, SCYA4 |
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manganese-containing superoxide dismutase |
Homo sapiens |
SOD2, MnSOD |
|
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metallothionein |
Saccharomyces cerevisiae |
CUP1, MTH1, YHR053C, YHR055C, CU-MT, copper chelatin |
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metallothionein-I |
Mus musculus |
MT1 |
|
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metallothionein IIA |
Homo sapiens |
MT-II, MT2A, MT2 |
|
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multidrug resistance |
Homo sapiens |
MDR1, P-glycoprotein 1, PGY1, ABCB1 |
|
|
multidrug resistance 1b |
Rattus norvegicus |
MDR1B, MDR1, P-glycoprotein 1, PGY1, PGY1-1, ABCB1 |
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multidrug resistance gene 1b |
Mus musculus |
MDR1, MDR1B, P-glycoprotein 1, PGY1, PGY1-1, ABCB1 |
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NAD(P)H:quinone oxidoreductase |
Homo sapiens |
NAD(P)H dehydrogenase 1, quinone reductase 1,QR1, DT-diaphorase, DTD, azoreductase, phylloquinone reductase,menadione reductase, DIA4, NMOR1, NQO1 |
|
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nitric oxide synthase |
Mus musculus |
nitric oxide synthase, inducible, NOS, TYPE II, inducible NOS, INOS, macrophage NOS, MAC-NOS, NOS2, INOSL |
|
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oncogene junB |
Mus musculus |
transcription factor JUN-B, JUNB, JUN-B |
|
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p21 Waf1 kinase inhibitor |
Homo sapiens |
cyclin-dependent kinase inhibitor 1, melanoma differentiation associated protein 6, MDA-6, P21, CDK-interacting protein 1, CDKN1A, CDKN1, CIP1, WAF1, MDA6, SDI1, PIC1, CAP20 |
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p53 induced |
Homo sapiens |
PIG3, NADPH quinone oxidoreductase homolog |
|
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p53 tumor suppressor |
Homo sapiens |
cellular tumor antigen P53, tumor suppressor p53, phosphoprotein, P53, TP53 |
|
|
p53 tumor suppressor |
Mus musculus |
cellular tumor antigen P53, tumor suppressor p53, phosphoprotein, P53, TP53 |
|
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prointerleukin-1beta |
Homo sapiens |
IL-1 beta, IL1B, catabolin |
|
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tartrate-resistant acid phosphatase |
Mus musculus |
TR-AP, tartrate-resistant acid atpase, tratpase, ACP5, TRAP, T5AP |
|
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tissue factor |
Mus musculus |
TF, coagulation factor III, F3, CF3, CF-3 |
|
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tissue factor |
Homo sapiens |
TF, coagulation factor III, thromboplastin, CD142 antigen, F3 |
|
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transferrin |
Homo sapiens |
serotransferrin precursor, siderophilin, beta-1-metal binding globulin, TF |
|
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transferrin receptor |
Homo sapiens |
TR, antigen CD71, T9, P90, TFRC |
|
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tumor necrosis factor alpha |
Homo sapiens |
TNF-alpha, cachectin |
|
|
type IV collagenase |
Homo sapiens |
72 kDA type IV collagenase precursor, 72 kDA gelatinase, matrix metalloproteinase-2, MMP-2, gelatinase A, TBE-1, MMP2, CLG4A |
|
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tyrosine phosphatase |
Homo sapiens |
dual specificity protein phosphatase 1, MAP kinase phosphatase-1, MKP-1, protein-tyrosine phosphatase, CL100, dual specificity protein phosphatase HVH1, DUSP1, PTPN10, MKP1, VH1 PRL-1 |
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vascular cell adhesion molecule 1 |
Homo sapiens |
cytokine-inducible adhesion molecule, V-CAM 1, CD106 antigen, INCAM-100 |