Comparison of the   correlation analysis results obtained by informational approach [4] with our data

 

16 highly correlated pairs from the work of Clarke [4] are represented in the first column.

The functional relationship between the residues at these positions (as inferred in [4]) are represented in second column: ± - salt bridge; P - interaction with phosphate backbone ; n - network of correlation betwen the residues of H3 helix in the magor groove of the DNA;   ? - functional relationship is unclear.

Partial correlation coefficients calculated by our approach with respect to isoelectric point (rij (pI)) and side chain volume  (rij (V)) characteristics are represented in the third and fourth columns, correspondingly. The correlation coefficients above 99.9% significance threshold (0.182) are in bold. 

 

Homeodomain position pairs

Functional relationship

rij.g (pI)

19-30

±

-0.33319

28-54

?

-0.08526

44-46

n

-0.16912

8-43

?

+0.07930

46-47

n

+0.11221

26-46

n

-0.25538

26-47

n

+0.02062

44-47

n

+0.09480

46-50

n

+0.02793

26-44

n

+0.26786

12-50

?

+0.03061

17-52

±

-0.27367

31-42

P

-0.29562

6-47

?

-0.02190

8-25

?

+0.32777

46-54

n

-0.11031