In this section, the user enters in line “DNA/protein Binding” data for each sequence variant, estimating the relative degree of protein binding on a scale of +1 (maximal) to –1 (minimal). In our example, it was experimentally determined that the gel mobility shift assay of the GpIbb gene allele “WT” contains a band corresponding to the DNA complex with unknown nuclear protein, whereas in case of “-133C/G” allele, this band is absent. There is an illustration how these experimental data are entered into the proper boxes of the field “DNA-protein binding”: i.e., the first allele, “WT”, was assigned the input value “+1”, and, the second allele, ““-133C/G”, the value “0”. Then the button “Calculate” should be clicked, following which the calculated values will appear in the window “Prediction”.