The analysis illustrates how the conserved physico-chemical
characteristics of proteins could be detected, if they are not known a priori.

Sample Data

Amino acid sequences were extracted from Pfam database (ID PF00046). Sequences with long gaps were removed. Identical sequences were also removed. The sample consists of 372 sequences.

Sequence alignment

Phylogenetic tree

Physico-chemical characteristics

Isoelectric point characteristics for amino acids

Results of pairwise CRASP calculation for isoelectric point characteristic

Amino acid occurences at alignment positions
Positional data (means and variances for alignment positions)
Linear correlation coefficients matrix (text; html; picture; distribution)
Partial correlation coefficients matrix (text; html; picture; distribution)

Testing the stability of the correlation coefficients estimates

Results for best correlated pairs

Comparison with the result of Clarke, 1995 [4]

Detecting correlation network

Isoelectric point values

References