Designations. On an axes abscissas - sequence DNA mobile element in bp; on an ordinate axis - ascribed numbers of the regulatory sites (their titles are reduced in tab.1); 1 group - the sites of replication and transcription initiation and termination; 2 group - enhancers and silencers of chromosomal, viral, etc., genes; 3 group - the sites recognized by cellular protein transcription and translation factors; and 4 group - the sites recognized by protein receptors for inductive signals; the arrows mark the discovered location of regulatory sites on the left-directed (leftward arrows) and right-directed (rightward arrows) DNA strands.
(b) Schematic structure of the DNA sequence of retrotransposon Line-1.
Designations. UTR, long terminal repeats; ORF1 and ORF2, big open reading frame; RT, of reverse transcriptase domain; I, of integrase domain.
(c) Consolidated distribution of the revealed motifs of functional sites along the Line-1 DNA sequence.
Designations. On an axes abscissas - number of segments of genome each size 1/15 length given MGE; on an ordinate axis - total number of nucleotides contained in the motifs of functional sites and falling within the scanning window by a size 75 bp. The upper direct line - 95%th level of the nonrandomness of the condensations of the motifs of functional sites; the lower direct line - average for 50 of casual sequences the same lengths and same nucleotide's of structure as DNA Line-1 distribution of motives functional saites.
Jamming of the motifs correlates with the locations of potential regulatory regions within UTR and in the vicinity of the ends (start and beginning) of the ORFs and domains of the ORF2.